全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

白屈菜红碱药理活性研究进展

Keywords: 白屈菜红碱,药理活性,研究进展

Full-Text   Cite this paper   Add to My Lib

Abstract:

白屈菜红碱是一种苯并菲啶型生物碱,普遍存在于紫堇科、罂粟科、毛莨科和芸香科等植物中,具有抗肿瘤、抗菌和抗炎等药理活性。该文对近10年来国内外关于白屈菜红碱的药理活性的研究进展进行了综述,期望为白屈菜红碱深入研究及开发利用提供一定的科学依据。

References

[1]  黄馨慧,罗明志,齐浩,等.龙胆苦昔等6种中草药提取物对SMMC-7721人肝癌细胞增殖的影响[J].西北药学杂志,2004,19(4): 166.
[2]  Malikova J, Zdarilova A, Hlobilkova A, et al. The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine[J]. Cell Biol Toxicol, 2006, 22(6): 439.
[3]  贺云鹏. 白屈菜红碱抗肺癌活性及其相关机制[J]. 中国老年学杂志, 2011, 31: 4690.
[4]  Platzbecker U, Ward J L, Deeg H J. Chelerythrin activates caspase-8, downregulates FLIP long and short, and overcomes resistance to tumour necrosis factor-related apoptosis-inducing ligand in KG1a cells[J]. Br J Haematol, 2003, 122(3): 489.
[5]  Simonis G, Wiedemann S, Schwarz K, et al. Chelerythrine treatment influences the balance of pro- and anti-apoptotic signaling pathways in the remote myocardium after infarction[J]. Mol Cell Biochem, 2008, 310(1/2):119.
[6]  Yu R, Mandlekar S, Tan T H, et al. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C[J]. J Biol Chem, 2000, 275(13): 9612.
[7]  Vrba J, Dolezel P, Vicar J, et al. Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells[J]. Toxicol In Vitro, 2008, 22(4): 1008.
[8]  刘帆,张正付,魏雄辉.白屈菜红碱对宫领癌细胞的抑制作用研究[J].现代生物医学进展,2009,9(3): 514.
[9]  Funakoshi T, Aki T, Nakayama H, et al. Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine[J]. Toxicol in Vitro, 2011, 25: 1581.
[10]  陈志宝,李欣燃,朱淼,等.白屈菜红碱抗肿瘤机制研究进展[J].江苏农业科学,2013,41(1): 9.
[11]  程睿波,陈旭,刘淑杰,等.白屈菜红碱对变形链球菌产酸抑制作用的实验研究[J].实用口腔医学杂志,2008,24(3): 364.
[12]  Liang J, Zeng F, Guo A, et al. Microarray analysis of the chelerythrine-induced transcriptome of Mycobacterium tuberculosis[J]. Curr Microbiol, 2011, 62: 1200.
[13]  范海延,薛广厚,吕春茂,等. 白屈菜中白屈菜红碱的提取及抑菌活性[J]. 食品科学, 2009, 30(24): 126.
[14]  潘萌. 小果博落回中生物碱的提取分离及抑菌活性研究. 杨凌:西北农林科技大学, 2012.
[15]  Yang X J, Miao F, Yao Y, et al. In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic Fungi[J]. Molecules, 2012, 17(11): 13026.
[16]  Pěncííková K, Kollár P, Müller Závalová V, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line[J]. Phytomedicine, 2012, 19(10): 890.
[17]  Niu X F, Zhou P, Li W F, et al. Effects of chelerythrine, a specic inhibitor of cyclooxygenase-2, on acute inflammation in mice[J]. Fitoterapia, 2011, 82(4): 620.
[18]  Li W F, Fan T, Zhang Y M, et al. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway[J]. Inflammation, 2012, 35(6): 1814.
[19]  Li X L, Yao J Y, Zhou Z M, et al. Activity of the chelerythrine, a quaternary benzo[c] phenanthridine alkaloid from Chelidonium majus L. on Dactylogyrus intermedius[J]. Parasitol Res, 2011, 109: 247.
[20]  彭飞. 血水草白屈菜红碱灭螺效果及对钉螺肝脏损伤机理的研究[D]. 长沙:湖南师范大学, 2012.
[21]  Miao F,Yang X J, Ma Y N, et al. Structural modification of sanguinarine and chelerythrine and their in vitro acaricidal activity against Psoroptes cuniculi[J]. Chem Pharm Bull (Tokyo), 2012, 60(12): 1508.
[22]  Urbanová J, Lubal P, Slaninová I, et al. Fluorescence properties of selected benzo[c] phenantridine alkaloids and studies of their interaetion with CT DNA[J]. Anal Bioanal Chem, 2009, 394(4): 997.
[23]  宗永立,刘艳平.白屈菜红碱诱导细胞凋亡的机理综述[J].时珍国医国药,2006,17(10): 2068.
[24]  Chmura S J, Dolan M E, Cha A, et al. In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo[J]. Clin Cancer Res, 2000, 6(2): 737.
[25]  Zhang Z F, Guo Y, Zhang J B, et al. Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell[J]. Arch Pharm Res, 2011, 34(5): 791.
[26]  Zhang Z F, Guo Y, Zhang L W, et al. Chelerythrine chloride from Macleaya cordata induces growth inhibition and apoptosis in human gastric cancer BGC-823 cells[J]. Acta Pharm Sin B, 2012, 2(5): 464.
[27]  Bai L P, Zhao Z Z, Cai Z W, et al. DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine,chelerythrine,and nitidine[J]. Bioorg Med Chem, 2006, 14: 5439.
[28]  Li J F, Li B H, Wu Y B, et al. Luminescence and binding properties of two isoquinoline alkaloids chelerythrine and sanguinarine with ctDNA[J]. Spectrochim Acta Part A: Mol Biomol Spectrosc, 2012, 95: 80.
[29]  Bai L P, Zhao Z Z, Cai Z, et al. Site-specific binding of chelerythrine to single cytosine and thymine bulges in DNA hairpins[J]. Nucleic Acids Symp Ser (Oxf), 2006, 50: 197.
[30]  Bai L P, Cai Z, Zhao Z Z, et al. Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA[J]. Anal Bioanal Chem, 2008, 392: 709.
[31]  Kaminskyy V, Lin K W, Filyak Y, et al. Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells[J].Cell Biol Int, 2008, 32: 271.
[32]  宗永立,刘艳平.白屈菜红碱对人胃癌BGC823细胞的增殖抑制和凋亡诱导作用[J].中草药,2006,37(7): 1054.
[33]  Harmati G, Papp F, Szentandrássy N, et al. Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF109203X) on delayed rectifier K currents[J]. Naunyn-Schmied Arch Pharmacol, 2011, 383(2): 141.
[34]  乔俏,李光,陈延治,等. PKC抑制剂对人胰腺癌细胞的放射增敏效应[J].中华放射医学与防护杂志,2005,25(5): 435.
[35]  高志强,唐亮,栗波,等.蛋白激酶C抑制剂对人非小细胞肺癌细胞株药物敏感性的影响[J].中国肺癌杂志,2007,10(6): 455.
[36]  Yang R, Piperdi S, Gorlick R. Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma[J]. Clin Cancer Res, 2008, 14: 6396.
[37]  曹喆,王丽娟,吴明辉,等. 白屈菜红碱逆转人乳腺癌多药耐药的机制[J]. 中国医学科学院学报, 2011, 33(1): 45.
[38]  Zdarilova A, Malikova J, Dvorak Z, et al. Quaternary isoquinoline alkaloids sanguinarine and chelerythrine. In vitro and in vivo effects[J]. Chem Listy, 2006, 100: 30.
[39]  Miao F, Yang X J, Zhou L, et al. Structural modification of sanguinarine and chelerythrine and their antibacterial activity[J]. Nat Prod Res, 2011, 25: 863.
[40]  Kokoska L, Polesny Z, Rada,V, et al. Screening of some Siberian medicinal plants for antimicrobial activity[J]. J Ethnopharmacol, 2002, 82(1): 51.
[41]  程睿波,陈旭,刘淑杰,等.白屈菜提取物抑制变链菌的实验研究[J].上海口腔医学,2006,15(3): 318.
[42]  程睿波,陈旭,刘淑杰,等.白屈菜红碱对变形链球菌表面疏水性及黏附作用的影响[J].上海口腔医学,2007,16(1): 68.
[43]  程睿波,陈旭,刘淑杰,等.白屈菜红碱对变形链球菌葡萄糖基转移酶和细胞外水不溶性多糖的影响[J].上海口腔医学,2007,16(3):324.
[44]  陈旭,程睿波.白屈菜红碱对伴放线放线杆菌的抑制作用研究[J].口腔医学研究,2007,23(6): 715.
[45]  Meng F Y, Zuo G Y, Hao X Y, et al. Antifungal activity of the benzo[c] phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates[J]. J Ethnopharmacol, 2009, 125: 494.
[46]  罗珊,虞欢,王玲.血水草白屈菜红碱杀灭日本血吸虫尾蚴预防感染的研究[J].湖南师范大学学报:医学版,2012,9(1): 28.
[47]  Szeto C C, Lai K B, Chow K M, et al. Differential effects of transforming growth factor-beta on the synthesis of connective tissue growth factor and vascular endothelial growth factor by peritoneal mesothelial cell[J]. Nephron Exp Nephrol, 2005, 99(4): e95.
[48]  李映菊,汪煜华,刘玉美,等.白屈菜红碱对肝纤维化大鼠肝脏病理学和肝脏羟脯氨酸含量的影响[J].实用肝脏病杂志,2009,12(3): 167.
[49]  李映菊,汪煜华,刘映霞.白屈菜红碱对肝纤维化大鼠肝脏TGF-β1和α-SMA表达的影响[J].世界华人消化杂志,2009,17(18): 1821.
[50]  汪煜华,李映菊,刘运美.白屈菜红碱对肝纤维化大鼠血清透明质酸和谷丙转氨酶的影响[J].南华大学学报:医学版,2010,38(3): 325.
[51]  张文斌,王敏,周斌全.白屈菜红碱逆转不同浓度葡萄糖培养的乳鼠心肌细胞肥大及其相关机制的探讨[J].药学学报,2009,44(2): 115.
[52]  杨鑫,范小平,向学熔,等.人颊黏膜成纤维细胞的原代培养及白屈菜红碱对其生长抑制的影响[J].重庆医学,2009,38(23): 2924.
[53]  Brunhofer G, Fallarero A, Karlsson D, et al. Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine[J]. Bioorg Med Chem, 2012, 20(22): 6669.
[54]  Kamins\'kyi V O, Kryv\'iak N V, Lutsyk M D, et al. Effect of alkaloids from celandine on calcium accumulation and oxidative phosphorylation in mitochondria depending on their DNA intercalating properties[J]. Ukr Biokhim Zh, 2006, 78(2): 73.
[55]  Tan I, Lai J, Yong J, et al. Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase[J]. FEBS Lett, 2011, 585: 1260.
[56]  林飞,马新群,吕廉,等.抗肿瘤药物白屈菜红碱的急性毒性试验研究[J].实用肿瘤学杂志,2010,24(5): 415.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133