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中药治疗HAART相关血脂异常的临床研究

Keywords: 消脂颗粒,二陈汤,桃红四物汤,血脂康胶囊,HAART治疗,血脂异常

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Abstract:

目的:评价以消脂颗粒及二陈汤和桃红四物汤为组方的中药制剂与血脂康胶囊治疗HAART致血脂异常的有效性和安全性。方法:采用多中心、随机对照的研究方法将180例HAART致血脂异常患者随机分为治疗组和对照组,观察指标为治疗前及治疗后第4,8,12周检测患者的总胆固醇(Tch)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)。结果:在治疗后第12周与对照组比较,治疗组患者Tch,LDL的变化有明显差异(P<0.05),TG的变化无明显差异,对照组患者Tch,LDL下降优于治疗组;治疗组患者HDL的升高值有显著差异(P<0.05),治疗组患者HDL的升高优于对照组。结论:血脂康胶囊和以消脂颗粒及二陈汤和桃红为组方的中药配方颗粒制剂可以作为防治我国HAART致血脂异常患者的主要中药制剂之一。

References

[1]  中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390.
[2]  郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:85.
[3]  Hogg R S, Yip B, Kully C, et al. Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens[J]. Can Med Assoc J,1999,160(5):659.
[4]  Law M G, Friis-Moller N, El-Sadr W M, et al. The use of the Framingham equation to predict myocardial infarctions in HIV-infected patients: comparison with observed events in the D:A:D study[J]. HIV Med,2006,7(4):218.
[5]  Dubé M P, Stein J H, Aberg J A, et al. Guidelines for the evaluation and management of dyslipidemia in human immunodeficiency virus (HIV)-infected adults receiving antiretroviral therapy: recommendations of the HIV medical association of the infectious disease society of America and the adult AIDS clinical trials group[J]. Clin Infect Dis,2003,37(5):613.
[6]  Lundgren J D, Battegay M, Behrens G, et al. European AIDS clinical society (EACS) guidelines on the prevention and management of metabolic diseases in HIV[J]. HIV Med,2008,9(2):72.
[7]  Mallewa J E, Wilkins E, Vilar J. et al.HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options[J].J Antimicrob Chemother, 2008,62(4):648.
[8]  Lucas G M, Chaisson R E, Moore R D. Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions[J].Ann Intern Med,1999,131(2):81.
[9]  Friis-Moller N, Weber R, D\'Arminio Monforte A, et al. Exposure to HAART is associated with an increased risk of myocardial infarction: the DAD study [C]. Boston: 10th Conference on Retroviruses and Opportunistic Infections, 2003.
[10]  Bozzette S A, Ake C, Carpenter A, et al.Cardio and cerebrovascular outcomes with changing process of anti-HIV therapy in 36,766 US veterans [C]. Washington: 9th Conference on Retroviruses and Opportunistic Infections, 2002.
[11]  Lee E C, Walmsley S, Fantus I G. New-onset diabetes mellitus associated with protease inhibitor therapy in an HIV-positive patient: case report and review[J]. Can Med Assoc J, 1999,161(2):161.
[12]  Carr A, Samaras K, Chisholm D J, et al. Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidemia, and insulin resistance[J].Lancet,1998,351(9119):1881.
[13]  寇文镕.血脂康防止冠心病若干研究进展[J].中国全科医学,2007(15):1294.
[14]  血脂康胶囊临床应用中国专家共识组.血脂康胶囊临床应用中国专家共识[J].中华内科杂志,2009,48(2):171.
[15]  陆宗良,邱宗英,刘苏,等.血脂康治疗高脂血症的临床观察[J].中国循环杂志,1997,12(1):12.
[16]  Zhao S P,Liu L,Cheng Y C,et al.Effect of xuezhikang,a cholestin extract,on reflecting postprandial triglyceridemia after a high-fat meal in patients with coronary heart disease[J]. Atherosclerosis,2003,168(2):375.
[17]  吴永健,俞虹,秦学文,等.不同类型高脂血症小而密低密度脂蛋白的水平及调血脂治疗对其影响[J].中国循环杂志,2002,17(6):430.
[18]  徐伯平,程蕴琳,鲁翔.血脂康对低密度脂蛋白体外氧化修饰的影响[J].中华内科杂志,1999,38(8):520.
[19]  陆国平,霍淑钦,沈永初,等.血脂康和辛伐他汀对高胆固醇血症调脂作用的比较[J].中华内科杂志,1998,37(6):371.
[20]  Liu L,Zhao S P,Cheng Y C,et al.Xuezhikang decreases serum lipoprotein(a) and C-reactive protein concentrations in patients with coronary heart disease[J].Clin Chem,2003,49(8):1347.
[21]  Zhao S P,Liu L,Cheng Y C,et al.Effect of xuezhikang,a cholestin extract,on reflecting postprandial triglyceridemia after a high-fat meal in patients with coronary heart disease[J]. Atherosclerosis,2003,168(2):375.
[22]  Detels R, Munoz A, McFarlane G, et al. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS cohort study investigators[J].J Am Med Assoc,1998,280(17):1497.
[23]  Cicconi P, Cozzi-Lepri A, Castagna A, et al.Insights into reasons for discontinuation according to year of starting first regimen of highly active antiretroviral therapy in a cohort of antiretroviral-naive patients[J]. HIV Med, 2010,11(2):104.
[24]  Lucas G M, Chaisson R E, Moore R D. Highly active antiretroviral therapy in a large urban clinic, risk factors for virologic failure and adverse drug reactions[J].Ann Intern Med,1999,131(2):81.
[25]  Chen D, Misra A, Garg A. Clinical review 153: lipodystrophy in human immunodeficiency virus-infected patients[J]. J Clin Endocrinol Metab,2002,87(11): 4845.
[26]  Kinlaw W B, Marsh B. Adiponectin and HIV-lipodystrophy: taking HAART[J]. Endocrinol,2004,145(2): 484.
[27]  邢小阳.防风通圣散治疗高脂血症40例[J].新中医,2002,34(5):58.
[28]  王卫霞,陈可冀.血脂康胶囊治疗高脂血症有效性和安全性的系统评价[J].中国循证医学杂志,2006,6(5):352.
[29]  中华医学会感染病学分会艾滋病学组.艾滋病诊疗指南[J].中华传染病杂志,2006,24(2):133.

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