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细胞膜色谱法在中药研究中的应用进展

Keywords: 细胞膜色谱法,中药,原理,特性,应用

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Abstract:

细胞膜色谱法(cellmembranechromatography,CMC)是由贺浪冲教授在1996年创建的一种新型的具有生物活性的亲和色谱技术.该技术将高效液相色谱、细胞生物学与受体药理学结合起来,通过将活性细胞膜固定在特定载体表面,制备成细胞膜固定相,用液相色谱的方法研究药物与固定相上细胞膜及膜受体的相互作用,利用药物与膜受体间存在的特异亲和力,将药物在体内的作用过程在色谱柱内进行动态模拟.该文重点针对CMC的原理、特性及在中药等方面的典型应用研究进行概述,为进一步深入研究和开发利用CMC提供理论依据和实践指导.

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