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肾小管上皮细胞间充质转分化的调控机制及中药的干预作用

Keywords: 慢性肾脏病,肾间质纤维化,肾小管上皮细胞间充质转分化,中药

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Abstract:

肾小管上皮细胞间充质转分化(epithelialtomesenchymaltransition,EMT)是肾间质纤维化(renalinterstitialfibrosis,RIF)的重要发病机制,其关键步骤包括"肾小管上皮细胞黏附性消失、间充质细胞标志性蛋白表达和细胞骨架蛋白重组、肾小管基底膜破坏、细胞迁移能力增强"等。这些关键步骤不仅与多条细胞信号通路的调控作用有关,而且,在体内外可被一些单味中药(黄芪、冬虫夏草、丹参等)及其提取物以及中药复方(黄芪当归合剂、益气活血方等)所干预。中药通过干预肾小管EMT病变过程而改善肾间质纤维化。

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