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肾脏细胞外基质降解的分子机制及中药的干预作用

Keywords: 慢性肾脏病,细胞外基质,基质金属蛋白酶,中药

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Abstract:

肾脏细胞外基质(extracellularmatrix,ECM)降解减少是慢性肾脏病(chronickidneydisease,CKD)肾组织损伤的形态特征和病理基础。在肾小球或肾间质中,ECM降解主要依赖于降解酶系统的调控,其中,基质金属蛋白酶(matrixmetalloproteinases,MMPs)发挥着核心作用。MMPs的表达和活性受控于"基因转录、酶原激活、特异性抑制剂"等经典途径。以尿毒清颗粒(UremicClearancegranule)为代表的中药复方制剂及中药提取物可以干预ECM降解的多种途径,包括促进ECM成分降解、影响ECM降解酶表达、调节MMPs基因转录、抑制MMPs相关信号转导等。

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