Rai P,Onder T T,Young J J,et al. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence[J].Proc Natl Acad Sci USA,2009,106(1) : 169.
[2]
Cao W, Li X Q, Wang X, et al.A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway[J]. Phytomedicine,2010,17(8/9):598.
[3]
Liu C,Li J,Meng F Y,et al. Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway[J]. BMC Complement Altern Med,2010,10: 79.
Zhao L, Wang Y, Shen H L,et al.Structural characterization and radioprotection of bone marrow hematopoiesis of two novel polysaccharides from the root of Angelica sinensis (Oliv.) Diels[J]. Fitoterapia, 2012,83(8):1712.
Zimmermann S, Martens U M. Telomeres, senescence, and hematopoietic stem cells[J]. Cell Tissue Res, 2008, 331(1):79.
[11]
Yue Zhou, Bing Yang, Xin Yao, et al. Establishment of an aging model of Sca-1+ hematopoietic stem cell and studies on its relative biological mechanisms[J]. In Vitro Cell Dev Biol Animal, 2011, 47(2):149.
[12]
Beerman I, Maloney W J, Weissmann I L,et al. Stem cells and the aging hematopoietic system[J]. Curr Opin Immunol,2010, 22(4):500.
[13]
Campisi J, Yaswen P. Aging and cancer cell biology[J]. Aging Cell,2009, 8(3):221.
[14]
Wang J W , Geiger H, Rudolph K L,et al. Immunoaging induced by hematopoietic stem cell aging[J]. Curr Opin Immunol, 2011, 23(4):532.
[15]
Wang Y, Liu L, Zhou D,et al. Inhibition of p38 MAPK attenuates ionizing radiation-induced hematopoietic cell senescence and residual bone marrow injury[J]. Radiat Res, 2011,176(6):743.
[16]
Yong W, Lingbo L, Senthil K,et al. Total body irradiation causes residual bone arrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells[J]. Free Radic Biol Med,2010,48(2): 348.
[17]
Dai D F,Rabinovitch P S,Ungvari Z. Mitochondria and cardiovascular aging[J].Circ Res,2012,110(8):1109.
[18]
Velarde M C, Flynn J M, Day N U, et al. Mitochondrial oxidative stress caused by Sod 2 deficiency promotes cellular senescence and aging phenotypes in the skin[J]. Aging (Albany NY), 2012,4(1):3.
[19]
Simon H U, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction[J]. Apoptosis, 2000,5 (5) :415.
[20]
Lee M Y,Wang Y,Vanhoutte P M. Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NF-kappaB[J].J Vasc Res,2009,47(4) : 287.
[21]
Michael W E, Hong W, Jeffrey A J. Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by Mn SOD-plasmid liposome administration[J]. Radiat Res,2011,175(6): 759.
[22]
Li Hongliang, Wang Y, Senthil K,et al. Mn (III) meso-tetrakis (N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression[J]. Free Radic Biol Med,2011,51(1): 30.
[23]
Fukuyo Y, Takahashi A, Hara E, et al. E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability[J]. Int J Oral Sci,2011,3(4):200.
[24]
Rayess H,Wang M B,Srivatsan E S.Cellular senescence and tumor suppressor gene p16 [J].Int J Cancer,2012,130(8):1715.
[25]
Baker D J, Wijshake T, Tchkonia T, et al. Clearance of p16 Ink4 apositive senescent cells delays ageing-associated disorders[J]. Nature,2011,479(7372):232.
[26]
Takahashi A, Ohtani N, Yamakoshi K, et al. Mitogenic signaling and the p16 INK4a2Rb pathway cooperate to enforce irreversible cellular senescence[J]. Nat Cell Biol , 2006,8(11):1291.
