Ohta H, Ni J W, Matsumoto K, et al. Peony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats [J]. Pharmacol Biochem Behav,1993,45(3):719.
Zhong S Z, Ge Q H, Li Q, et al. Peoniflorin attentuates Abeta (1-42)-mediated neurotoxicity by regulating calcium homeostasis and ameliorating oxidative stress in hippocampus of rats [J]. J Neurol Sci,2009,280(1/2):71.
[4]
Hu Z Y, Liu G, Yuan H, et al. Danggui-Shaoyao-San and its active fraction JD-30 improve Abeta-induced spatial recognition deficits in mice [J]. J Ethnopharmacol,2010,128(2):365.
[5]
Hu Z Y, Liu G, Cheng X R, et al. JD-30, an active fraction extracted from Danggui-Shaoyao-San, decreases beta-amyloid content and deposition, improves LTP reduction and prevents spatial cognition impairment in SAMP8 mice [J]. Exp Gerontol,2012,47(1):14.
[6]
Abdel-Hafez A A, Meselhy M R, Nakamura N, et al. Effects of paeoniflorin derivatives on scopolamine-induced amnesia using a passive avoidance task in mice: structure-activity relationship [J]. Biol Pharm Bull,1998,21(11):1174.
[7]
Xiao L, Wang Y Z, Liu J, et al. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats [J]. Life Sci,2005,78(4):413.
[8]
Yu H Y, Liu M G, Liu D N, et al. Antinociceptive effects of systemic paeoniflorin on bee venom-induced various \'phenotypes’ of nociception and hypersensitivity [J]. Pharmacol Biochem Behav, 2007, 88(2):131.
[9]
Yu H Y, Mu D G, Chen J, et al. Suppressive effects of intrathecal paeoniflorin on bee venom-induced pain-related behaviors and spinal neuronal activation [J]. Pharmacology,2011,88(3/4):159.
[10]
Tsai H Y, Lin Y T, Tsai C H, et al. Effects of paeoniflorin on the formalin-induced nociceptive behaviour in mice [J]. J Ethnopharmacol,2001,75(2/3):267.
[11]
Liu D Z, Zhao F L, Liu J, et al. Potentiation of adenosine A1 receptor agonist CPA-induced antinociception by paeoniflorin in mice [J]. Biol Pharm Bull,2006,29(8):1630.
[12]
Tabata K, Matsumoto K, Watanabe H. Paeoniflorin, a major constituent of peony root, reverses muscarinic M1-receptor antagonist-induced suppression of long-term potentiation in the rat hippocampal slice [J]. Jpn J Pharmacol,2000,83(1):25.
Ohta H, Matsumoto K, Watanabe H, et al. Involvement of alpha 1- but not alpha 2-adrenergic systems in the antagonizing effect of paeoniflorin on scopolamine-induced deficit in radial maze performance in rats [J]. Jpn J Pharmacol,1993,62(2):199.
[15]
Ohta H, Matsumoto K, Watanabe H, et al. Involvement of beta-adrenergic systems in the antagonizing effect of paeoniflorin on the scopolamine-induced deficit in radial maze performance in rats [J]. Jpn J Pharmacol,1993,62(4):345.
[16]
Tabata K, Matsumoto K, Murakami Y, et al. Ameliorative effects of paeoniflorin, a major constituent of peony root, on adenosine A1 receptor-mediated impairment of passive avoidance performance and long-term potentiation in the hippocampus [J]. Biol Pharm Bull,2001,24(5):496.
[17]
Tsai T-Y, Wu S N, Liu Y-C, et al. Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells [J]. Eur J Pharmacol,2005,523(1/3):16.
[18]
Zhang G Q, Hao X M, Chen S Z, et al. Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons [J]. Acta Pharmacol Sin,2003,24(12):1248.
[19]
Cao B Y, Yang Y P, Luo W F, et al. Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway [J]. J Ethnopharmacol,2010,131(1):122.
[20]
Sun X, Cao Y B, Hu L F, et al. ASICs mediate the modulatory effect by paeoniflorin on alpha-synuclein autophagic degradation [J]. Brain Res,2011,1396:77.
Liu H Q, Zhang W Y, Luo X T, et al. Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson\'s disease by activation of adenosine A1 receptor [J]. Br J Pharmacol,2006,148(3):314.
[24]
Liu D Z, Zhu J, Jin D Z, et al. Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson\'s disease [J]. J Ethnopharmacol,2007,112(2):327.
[25]
Liu J, Jin D Z, Xiao L, et al. Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats [J]. Brain Res, 2006, 1089(1):162.
[26]
Liu D Z, Xie K Q, Ji X Q, et al. Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists [J]. Br J Pharmacol,2005,146(4):604.
[27]
Tang N Y, Liu C H, Hsieh C T, et al. The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats [J]. Am J Chin Med,2010,38(1):51.
[28]
Chen D M, Xiao L, Cai X, et al. Involvement of multitargets in paeoniflorin-induced preconditioning [J]. J Pharmacol Exp Ther,2006,319(1):165.
