Bazzaz FA, Dusek D, Seigler DS, Haney AW.Photosynthesis and cannabinoid content of temperate and tropical populations of Cannabis sativa[J].Biochem Syst Ecol,1975,3:15-18
[3]
Bócsa I, Mathé P, Hangyel L.Effect of nitrogen on tetrahydrocannabinol (THC) content in hemp (Cannabis sativa L) leaves at different positions.[J].J Int Hemp Assoc,1997,4:80-81
[4]
Cole MD . The analysis of controlled substances. Sussex: John Wiley & Sons Ltd. pp. 49-72.[J].,2003,:-
[5]
Croteau R.Biosynthesis and catabolism of monoterpenes[J].Chem Rev,1987,87:929-954
[6]
de Meijer EPM, Bagatta M, Carboni A, Crucitti P, Moliterni VMC, Ranalli P, Mandolino G.The Inheritance of Chemical Phenotype in Cannabis sativa L.[J].Genetics,2003,163:335-346
[7]
de Meijer EPM, Hammond KM.The inheritance of chemical phenotype in Cannabis sativa L (II): cannabigerol predominant plants. [J].Euphytica,2005,145:189-198
[8]
de Meijer EPM, Hammond KM, Micheler M.The inheritance of chemical phenotype in Cannabis sativa L (III): variation in cannabichromene proportion.[J].Euphytica,2008,165:293-311
[9]
Dittrich H, Kutchan TM.Molecular cloning, expression and induction of berberine bridge enzyme, an enzyme essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack[J].Proc Natl Acad Sci USA,1991,88:9969-9973
[10]
ElSohly MA, Slade D.Chemical constituents of marijuana: the complex mixture of natural cannabinoids[J].Life Sci,2005,78:539-548
[11]
Fellermeier M, Zenk MH . Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol[J].FEBS Lett,1998,427:283-285
Morimoto S, Komatsu K, Taura F, Shoyama Y.Purification and characterization of cannabichromenic acid synthase from Cannabis sativa[J].Phytochemistry,1998,49:1525-1529
[14]
Radwan MM, Ross SA, Slade D, Ahmed SA, Zulfiqar F, ElSohly MA.Isolation and characterization of new cannabis constituents from a high potency variety[J].Planta Med,2008,74:267-272
[15]
Raharjo TJ, Chang WT, Verberne MC, Peltenburg-Looman AM, Linthorst HJ, Verpoorte R.Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa[J].Plant Physiol Biochem,2004,42:291-297
[16]
Robson P. Human studies of cannabinoids and medicinal cannabis. In: Pertwee RG, ed. Cannabinoids Handbook of Experimental Pharmacology, Heidelberg: Springer-Verlag. [J].,2005,:719-756
[17]
Shoyama Y, Hirano H, Nishioka I.Biosynthesis of propyl cannabinoid acid and its biosynthetic relationship with pentyl and methyl cannabinoid acids[J].Phytochemistry,1984,23:1909-1912
[18]
Shoyama Y, Yagi M, Nishioka I, Yamauchi T.Biosynthesis of cannabinoid acids[J].Phytochemistry,1975,14:2189-2192
[19]
Sirikantaramas S, Morimoto S, Shoyama Y, Ishikawa Y, Wada Y, Shoyama Y, Taura F.The Gene Controlling Marijuana Psychoactivity[J].J Biol Chem,2004,279:39767-39774
[20]
Sirikantaramas S, Taura F, Tanaka Y, Ishikawa Y, Morimoto S, Shoyama Y.Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes[J].Plant Cell Physiol,2005,46:1578-1582
[21]
Small E, Beckstead HD. Cannabinoid phenotypes in Cannabis sativa. [J].Nature,1973,245:147-148
[22]
Small E, Beckstead HD.Common cannabinoid phenotypes in 350 stocks of Cannabis. [J].Lloydia,1973,36:144-165
[23]
Steffens P, Nagakura N, Zenk MH.Purification and characterization of the berberine bridge enzyme from berberis beaniana cell cultures[J].Phytochemistry,1985,24:2577-2583
[24]
Taura F. Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana. [J].Drug Discov Ther,2009, 3:83-87
[25]
Taura F, Dono E, Sirikantaramas S, Yoshimura K, Shoyama Y, Morimoto S . Production of D1-tetrahydrocannabinolic acid by the biosynthetic enzyme secreted from transgenic Pichia pastoris[J].Biochem Biophys Res Commun,2007,361:675-680
[26]
Taura F, Morimoto S, Shoyama Y. Cannabinerolic acid, a cannabinoid from Cannabis sativa.[J].Phytochemistry,1995,39:457-458
[27]
Taura F, Morimoto S, Shoyama Y.Purification and characterization of cannabidiolic-acid synthase from cannabis sativa L[J].J Biol Chem,1996,271:17411-17416
[28]
Taura F, Morimoto S, Shoyama Y, Mechoulam R. First direct evidence for the mechanism of Δ1-tetrahydrocannabinolic acid biosynthesis.[J].J Am Chem Soc,1995,117:9766-9767
[29]
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S.Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa[J].FEBS Lett,2007,581:2929-2934.
[30]
Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S.Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway[J].FEBS Lett,2009,583:2061-2066
[31]
United Nations Office on Drugs and Crime (UNODC) . Recommended Methods for the Identification and Analysis of Cannabis and Cannabis Products. New York: United Nations Publication. [J].,2009,:14-16
[32]
Valle JR, Vieira JEV, Auceélio JG, Valio IFM.Influence of photoperiodism on cannabinoid content of Cannabis sativa L[J].Bull Narc,1978,30:67-68
[33]
Vogelmann AF, Turner JC, Mahlberg PG.Cannabinoid composition in seedlings compared to adult plants of Cannabis sativa[J].J Nat Prod,1988,51:1075-1079
[34]
Yamauchi T, Shoyama Y, Aramaki H, Azuma T, Nishioka I.Tetrahydrocannabinolic acid, a genuine substance of tetrahydrocannabinol[J].Chem Pharm Bull (Tokyo,1967,15:1075-1076
Appendino G, Gibbons S, Giana A, Pagani A, Grassi G, Stavri M, Smith E, Rahman MM.Antibacterial cannabinoids from Cannabis sativa: a structure-activity study[J].J Nat Prod,2008,71:1427-1430
[41]
Astres-Becker I, Molina-Holgado F, Ramos JA, Mechoulam R, Fernandez-Ruiz J.Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease[J].Neurobiol Dis,2005,19:96-107
[42]
Fellermeier, M, Eisenreich W, Bacher A, Zenk MH.Biosynthesis of cannabinoids Incorporation experiments with 13C-labeled glucoses. [J].Eur J Biochem,2001,268:1596-1604
[43]
Fetterman PS, Keith ES, Waller CW, Guerrero O, Doorenbos NJ, Quimby MW.Mississippi-grown Cannabis sativa L Preliminary observation on chemical definition of phenotype and variations in tetrahydrocannabinol content versus age, sex, and plant part.[J].J Pharm Sci,1971,60:1246-1249
[44]
Flores-Sanchez IJ. Polyketide synthases in Cannabis sativa L. Polyketide Synthases in Cannabis sativa L., ChapterⅢ: Polyketide synthase activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants. Amsterdam: PrintPartners Ipskamp B.V. [J].,2008,:58-59
[45]
Flores-Sanchez IJ, Verpoorte R.Secondary metabolism in cannabis[J].Phytochemistry Rev,2008,:615-639
[46]
Fournier G, Richez-Dumanois C, Duvezin J, Mathieu JP, Paris M.Identification of a new chemotype in Cannabis sativa: cannabigerol-dominant plants, biogenetic and agronomic prospects[J].Planta Med,1987,53:277-280
[47]
Fujita M, Hiroko S, Kuriyama E, Shigehiro M.Studies on Cannabis II. Examination of the narcotic and its related components in hemps, crude drugs, and plant organs by gas-liquid chromatography and thin-layer chromatography. [J].Annu Rep Tokyo Coll Pharm,1967,17:238-242
Hillig KW, Mahlberg PG.A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae)[J].Am J Bot,2004,91:966-975
[50]
Kojoma M, Seki H, Yoshida S, Muranaka T.DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in “drug-type” and “fiber-type” Cannabis sativa L[J].Forensic Sci Int,2006,159:132-140
