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科学通报  2012 

非编码RNA在肿瘤发生中的不同作用

DOI: 10.1360/csb2012-57-2-3-104, PP. 104-111

Keywords: 非编码RNA,肿瘤,microRNA

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Abstract:

哺乳动物中大部分基因通过转录产生大量的非编码RNA.过去的10余年间,microRNA和siRNA2种小分子非编码RNA以及其他各种类型非编码RNA的发现,极大地促进了生物学发展.非编码RNA研究领域也不断被拓展.最近不少文献报道了miRNA和其他ncRNA的各种功能,如H19RNA、HOTAIR、超保守区域转录子、天然反义RNA、转运RNA和线粒体的非编码RNA等非编码RNA参与多种细胞活动,并与一些疾病及肿瘤相关.本文将介绍一些非编码RNA与肿瘤相关的最新研究进展,并着重讨论除microRNA以外其他ncRNA与肿瘤的关系.

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