3 Tattersall I. Human origins: Out of Africa. Proc Natl Acad Sci USA, 2009, 106: 16018–16021？？
[2]
4 Stoneking M. Human origins. The molecular perspective. EMBO Rep, 2008, 9(Suppl 1): S46–S50？？
[3]
5 Mellars P. A new radiocarbon revolution and the dispersal of modern humans in Eurasia. Nature, 2006, 439: 931–935？？
[4]
10 Banks J, Muriel A, Smith J P. Disease prevalence, disease incidence, and mortality in the United States and in England. Demography, 2010,47(Suppl): S211–S231？？
[5]
11 Roger V L, Go A S, Lloyd-Jones D M, et al. Heart disease and stroke statistics–2011 update: A report from the American Heart Association. Circulation, 2011, 123: e46–e215？？
[6]
12 Altshuler D, Daly M J, Lander E S. Genetic mapping in human disease. Science, 2008, 322: 881–888？？
[7]
14 Perry G H, Dominy N J, Claw K G, et al. Diet and the evolution of human amylase gene copy number variation. Nat Genet, 2007, 39:1256–1260？？
[8]
24 Roberts D F. Climate and Human Variability. Reading, MA: Addison-Wesley Pub Co, 1973
[9]
25 Johnson E F, McClure J, Herron P, et al. Anatomical variation, human diversity, and environmental adaptation. J Natl Med Assoc, 1993, 85:337–338
[10]
26 Jablonski N G, Chaplin G. The evolution of human skin coloration. J Hum Evol, 2000, 39: 57–106？？
[11]
27 IARC. IARC monographs on the evaluation of carcinogenic risks to humans. Solar and ultraviolet radiation. IARC Monogr Eval Carcinog Risks Hum, 1992, 55: 1–316
[12]
28 Jablonski N G, Chaplin G. Human skin pigmentation as an adaptation to UV radiation. Proc Natl Acad Sci USA, 2010, 107(Suppl 2):8962–8968？？
[13]
29 Gallagher R P, Lee T K, Bajdik C D, et al. Ultraviolet radiation. Chronic Dis Can, 2010, 29(Suppl 1): 51–68
[14]
30 Harding R M, Healy E, Ray A J, et al. Evidence for variable selective pressures at MC1R. Am J Hum Genet, 2000, 66: 1351–1361？？
[15]
32 Akey J M, Wang H, Xiong M, et al. Interaction between the melanocortin-1 receptor and P genes contributes to inter-individual variation in skin pigmentation phenotypes in a Tibetan population. Hum Genet, 2001, 108: 516–520？？
[16]
33 Izagirre N, Garcia I, Junquera C, et al. A scan for signatures of positive selection in candidate loci for skin pigmentation in humans. Mol Biol Evol, 2006, 23: 1697–1706？？
[17]
35 Stokowski R P, Pant P V, Dadd T, et al. A genomewide association study of skin pigmentation in a South Asian population. Am J Hum Genet,2007, 81: 1119–1132？？
[18]
36 Randall W. Sunshine rhythms, a possible Zeitgeber for multiphasic biological rhythms during a year. Biol Rhythm Res, 1970, 1: 389–404
38 Reiter R J, Tan D X, Fuentes-Broto L. Melatonin: A multitasking molecule. Prog Brain Res, 2010, 181: 127–151？？
[21]
41 Brunsdon C, McClatchey J, Unwin D J. Spatial variations in the average rainfall-altitude relationship in Great Britain: An approach using geographically weighted regression. Int J Climatol, 2001, 21: 455–466？？
[22]
44 Ladell W S S. Terrestrial animals in humid heat: Man. Handbook of Physiology, Section, 1964, 4: 625–659
[23]
47 Sawka M N, Montain S J, Latzka W A. Hydration effects on thermoregulation and performance in the heat. Comp Biochem Physiol A Mol Integr Physiol, 2001, 128: 679–690？？
[24]
48 Nakajima T, Wooding S, Sakagami T, et al. Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the world. Am J Hum Genet, 2004, 74: 898–916？？
[25]
49 Martin D, Windsor J. From mountain to bedside: Understanding the clinical relevance of human acclimatisation to high-altitude hypoxia. Postgrad Med J, 2008, 84: 622–627？？
[26]
50 Xu S, Li S, Yang Y, et al. A genome-wide search for signals of high-altitude adaptation in Tibetans. Mol Biol Evol, 2011, 28: 1003–1011？？
[27]
51 Peng Y, Yang Z, Zhang H, et al. Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol, 2011,28: 1075–1081？？
[28]
54 Beall C M, Cavalleri G L, Deng L, et al. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci USA, 2010, 107: 11459–11464？？
[29]
55 Bigham A, Bauchet M, Pinto D, et al. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet, 2010, 6: e1001116？？
[30]
56 Bigham A W, Mao X, Mei R, et al. Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics, 2009, 4: 79–90
[31]
59 Lundby C, Calbet J A, Robach P. The response of human skeletal muscle tissue to hypoxia. Cell Mol Life Sci, 2009, 66: 3615–3623？？
[32]
61 Tripathy V, Gupta R. Blood pressure variation among Tibetans at different altitudes. Ann Hum Biol, 2007, 34: 470–483？？
[33]
62 Niermeyer S. Cardiopulmonary transition in the high altitude infant. High Alt Med Biol, 2003, 4: 225–239？？
[34]
63 Leon-Velarde F, Villafuerte F C, Richalet J P. Chronic mountain sickness and the heart. Prog Cardiovasc Dis, 2010, 52: 540–549？？
[35]
67 Xing G, Qualls C, Huicho L, et al. Adaptation and mal-adaptation to ambient hypoxia: Andean, Ethiopian and Himalayan patterns. PLoS One,2008, 3: e2342？？
[36]
68 Khasnis A A, Nettleman M D. Global warming and infectious disease. Arch Med Res, 2005, 36: 689–696？？
[37]
69 McMichael A J, Woodruff R E, Hales S. Climate change and human health: Present and future risks. Lancet, 2006, 367: 859–869？？
[38]
70 Bohl D D, Katz K A, Bernstein K, et al. Prevalence and correlates of herpes simplex virus type-2 infection among men who have sex with men, san francisco, 2008. Sex Transm Dis, 2011, 38: 617–621
[39]
71 Loftus E V Jr. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology,2004, 126: 1504–1517？？
[40]
72 Silverberg M J, Jacobson L P, French A L, et al. Age and racial/ethnic differences in the prevalence of reported symptoms in human immunodeficiency virus-infected persons on antiretroviral therapy. J Pain Symptom Manage, 2009, 38: 197–207？？
[41]
74 Fumagalli M, Cagliani R, Pozzoli U, et al. Widespread balancing selection and pathogen-driven selection at blood group antigen genes. Genome Res, 2009, 19: 199–212
[42]
75 Fumagalli M, Pozzoli U, Cagliani R, et al. Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. J Exp Med, 2009, 206: 1395–1408？？
[43]
76 Ferwerda B, McCall M B, Alonso S, et al. TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci USA, 2007, 104: 16645–16650？？
[44]
77 Cordain L, Eaton S B, Sebastian A, et al. Origins and evolution of the Western diet: Health implications for the 21st century. Am J Clin Nutr,2005, 81: 341–354
[45]
80 Torniainen S, Parker M I, Holmberg V, et al. Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana. BMC Genet, 2009, 10: 31
[46]
81 Ingram C J, Raga T O, Tarekegn A, et al. Multiple rare variants as a cause of a common phenotype: Several different lactase persistence associated alleles in a single ethnic group. J Mol Evol, 2009, 69: 579–588？？
[47]
83 Hart T B, Hart J A. The ecological basis of hunter-gatherer subsistence in African rain forests: The Mbuti of eastern Zaire. Hum Ecol, 1986,14: 29–55？？
[48]
84 Tokarev S A. The yakuts. In: Levin M, Potapov L, eds. Peoples of Siberia. Chicago: University of Chicago Press, 1964. 243–304
[49]
85 Lebenthal E. Role of salivary amylase in gastric and intestinal digestion of starch. Dig Dis Sci, 1987, 32: 1155–1157？？
[50]
86 Neel J V. Diabetes mellitus: A “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet, 1962, 14: 353–362
[51]
87 Hales C N, Barker D J. The thrifty phenotype hypothesis. Br Med Bull, 2001, 60: 5–20？？
[52]
1 Relethford J H. Genetic evidence and the modern human origins debate. Heredity, 2008, 100: 555–563？？
[53]
2 McEvoy B P, Powell J E, Goddard M E, et al. Human population dispersal “Out of Africa” estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Res, 2011, 21: 821–829？？
[54]
6 Stanyon R, Sazzini M, Luiselli D. Timing the first human migration into eastern Asia. J Biol, 2009, 8: 18？？
[55]
7 Campbell M C, Tishkoff S A. The evolution of human genetic and phenotypic variation in Africa. Curr Biol, 2010, 20: R166–R173？？
[56]
8 Novembre J, Di Rienzo A. Spatial patterns of variation due to natural selection in humans. Nat Rev Genet, 2009, 10: 745–755？？
[57]
9 Abramson O, Durant M, Mow W, et al. Incidence, prevalence, and time trends of pediatric inflammatory bowel disease in Northern California,
[58]
1996 to 2006. J Pediatr, 2010, 157: 233–239
[59]
13 Frazer K A, Murray S S, Schork N J, et al. Human genetic variation and its contribution to complex traits. Nat Rev Genet, 2009, 10: 241–251
[60]
15 Tishkoff S A, Reed F A, Ranciaro A, et al. Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet, 2007, 39:31–40？？
[61]
16 Jablonski N G. The evolution of human skin and skin color. Annu Rev Anthropol, 2004, 33: 585–623？？
[62]
17 Katzmarzyk P T, Leonard W R. Climatic influences on human body size and proportions: Ecological adaptations and secular trends. Am J Phys Anthropol, 1998, 106: 483–503？？
[63]
18 Thompson E E, Kuttab-Boulos H, Witonsky D, et al. CYP3A variation and the evolution of salt-sensitivity variants. Am J Hum Genet, 2004,75: 1059–1069？？
[64]
19 Young J H, Chang Y P, Kim J D, et al. Differential susceptibility to hypertension is due to selection during the out-of-Africa expansion. PLoS Genet, 2005, 1: e82？？
[65]
20 Storz J F. Genes for high altitudes. Science, 2010, 329: 40–41？？
[66]
21 Bergmann С. über die Verh?ltnisse der W?rme?konomie der Thiere zu ihrer Gr?sse. G?ttinger Stud, 1847, 3: 595–708
[67]
22 Allen J A. The influence of physical conditions in the genesis of species. Rad Rev, 1877, 1: 108–140
[68]
23 Ruff C B. Morphological adaptation to climate in modern and fossil hominids. Am J Phys Anthropol, 1994, 37: 65–107？？
[69]
31 Savage S A, Gerstenblith M R, Goldstein A M, et al. Nucleotide diversity and population differentiation of the melanocortin 1 receptor gene, MC1R. BMC Genet, 2008, 9: 31
[70]
34 Norton H L, Kittles R A, Parra E, et al. Genetic evidence for the convergent evolution of light skin in Europeans and East Asians. Mol Biol Evol, 2007, 24: 710–722
[71]
39 Ciarleglio C M, Ryckman K K, Servick S V, et al. Genetic differences in human circadian clock genes among worldwide populations. J Biol Rhythms, 2008, 23: 330–340？？
[72]
40 Ji L D, Xu J, Wu D D, et al. Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations. J Pineal Res, 2010, 48: 133–141？？
[73]
42 Perry G H, Dominy N J. Evolution of the human pygmy phenotype. Trends Ecol Evol, 2009, 24: 218–225？？
[74]
43 Denton D, Weisinger R, Mundy N I, et al. The effect of increased salt intake on blood pressure of chimpanzees. Nat Med, 1995, 1: 1009–1016？？
[75]
45 Newman R W. Why man is such a sweaty and thirsty naked animal: A speculative review. Hum Biol, 1970, 42: 12–27
[76]
46 Cavalli-Sforza L L. African pygmies. In: Cavalli-Sforza L L, ed. African Pygmies: An Evaluation of the State of Research. Orlando: Academic Press, 1986
[77]
52 Yi X, Liang Y, Huerta-Sanchez E, et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science, 2010, 329: 75–78？？
[78]
53 Simonson T S, Yang Y, Huff C D, et al. Genetic evidence for high-altitude adaptation in Tibet. Science, 2010, 329: 72–75？？
[79]
57 Huicho L, Xing G, Qualls C, et al. Abnormal energy regulation in early life: Childhood gene expression may predict subsequent chronic mountain sickness. BMC Pediatr, 2008, 8: 47？？
[80]
58 Brutsaert T D. Do high-altitude natives have enhanced exercise performance at altitude? Appl Physiol Nutr Metab, 2008, 33: 582–592
[81]
60 Moore L G, Shriver M, Bemis L, et al. Maternal adaptation to high-altitude pregnancy: An experiment of nature–a review. Placenta, 2004,25(Suppl A): S60–S71？？
[82]
64 Palmer B F. Physiology and pathophysiology with ascent to altitude. Am J Med Sci, 2010, 340: 69–77
[83]
65 Beall C M, Decker M J, Brittenham G M, et al. An Ethiopian pattern of human adaptation to high-altitude hypoxia. Proc Natl Acad Sci USA,2002, 99: 17215–17218？？
[84]
66 Beall C M. Two routes to functional adaptation: Tibetan and Andean high-altitude natives. Proc Natl Acad Sci USA, 2007, 104(Suppl 1):8655–8660？？
[85]
73 Prugnolle F, Manica A, Charpentier M, et al. Pathogen-driven selection and worldwide HLA class I diversity. Curr Biol, 2005, 15: 1022–1027？？
[86]
78 Swallow D M. Genetics of lactase persistence and lactose intolerance. Annu Rev Genet, 2003, 37: 197–219？？
[87]
79 Copley M S, Berstan R, Dudd S N, et al. Direct chemical evidence for widespread dairying in prehistoric Britain. Proc Natl Acad Sci USA,2003, 100: 1524–1529？？
[88]
82 Draper H. The aboriginal Eskimo diet in modern perspective. Am Anthropol, 1977, 79: 309–316？？
