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科学通报  2013 

天然免疫中重要的接头分子的研究进展

DOI: 10.1360/972012-939, PP. 2021-2034

Keywords: 天然免疫,感染,细胞信号转导

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Abstract:

天然免疫信号通路中的模式识别受体(patternrecognitionreceptor,PRR),可识别入侵机体的外来微生物及机体自身的一些内源性物质,将信号中转至细胞内重要的枢纽分子MyD88/TRIF/MAVS/STING/caspase-1等进行整合,继而激活相应的转录因子IRF3/IRF7/NF-kB/AP-1及信号转导子和转录子STAT6,诱导下游靶基因,如Ⅰ型干扰素和炎症因子的表达,促进炎症小体的组装等.大多数细胞因子可进行旁分泌或自分泌并与其受体结合激活JAK-STAT信号通路,影响免疫细胞的活性、增殖与分化,进一步增强机体抵抗外界干扰的能力.本研究主要围绕天然免疫信号通路中几个重要的接头分子来展开对天然免疫信号级联网络的讨论.

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