功能磁共振用于肿瘤光热和光动力协同治疗的实时监测研究
Real-time monitoring of tumor response to photothermal/photodynamic therapy by functional magnetic resonance imaging

将实验动物分为光热治疗组、光动力治疗组、光热和光动力协同治疗组，使用T2加权和扩散加权两种磁共振成像方式对治疗效果进行实时监测，并使用病理学方法对磁共振检测效果进行验证. 实验结果发现，两个单纯治疗组中肿瘤并未被完全杀灭；而协同治疗组中，肿瘤被完全杀灭. 磁共振作为无创监测手段，在疗效评价中有巨大的应用价值，并可对纳米粒子的设计合成起到指导作用.
This paper assess the long-term curative effect of tumor after different treatment strategies. Compared with photodynamic therapy or photothermal therapy alone，the combined therapy showed a significantly synergistic effect，which was demonstrated by functional MRI. The results provide a direct，non-invasive method for in vivo monitoring of the treatment response to nanoparticle-mediated PTT，which can be used to guide cancer therapy to improve potential clinical outcomes