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科学通报  2011 

脂肪细胞分化:一个故事、两个章节

DOI: 10.1360/972011-630, PP. 1327-1334

Keywords: 脂肪细胞分化,细胞周期,3T3-L1,基因表达调控,表观遗传修饰

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Abstract:

细胞分化是多细胞个体发育和干细胞实现功能活动的基本过程.作为诱导白色脂肪细胞分化的体外模型,小鼠3T3-L1前脂肪细胞系的定向分化过程由依赖于细胞周期特定时相(接触抑制期)的许可阶段和独立于细胞周期的执行阶段所组成.在接触抑制期,通过细胞代谢方式、细胞周期调控因子和细胞信号转导通路之间的相互作用,决定了各种染色质表观遗传修饰因子的活动,从而导致具备脂肪细胞分化潜能的染色质表观遗传修饰模式的形成.在随后的执行阶段,这种分化潜能被激素诱发,通过复杂的基因调控网络的动态活动,使各种控制脂肪细胞分化基因表达的转录因子按既定的分化时间表打开或者关闭,并决定相关的靶基因的表达,最终导致了脂肪细胞的形成.

References

[1]  3 Green H, Kehinde O. Sublines of mouse 3T3 cells that accumulate lipid. Cell, 1974, 1: 113-116 ??
[2]  4 MacDougald O A, Lane M D. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem, 1995, 64: 345-373??
[3]  5 Gregoire F M, Smas C M, Sul H S. Understanding adipocyte differentiation. Physiol Rev, 1998, 78: 783-809
[4]  8 Guo W, Zhang J M, Tu K, et al. Adipogenesis licensing and execution are disparately linked to cell proliferation. Cell Res, 2009, 19: 216-223??
[5]  11 Musri M M, Corominola H, Casamitjana R, et al. Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes. J Biol Chem, 2006, 281: 17180-17188??
[6]  13 Pieper R O, Lester K A, Fanton C P. Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts. Nucleic Acids Res, 1999, 27: 3229-3235??
[7]  15 Fu M, Rao M, Bouras T, et al. Cyclin D1 inhibits PPARg-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem, 2005, 280: 16934-16941??
[8]  26 Müller G. Take-over: Multiple mechanisms of inter-adipocyte communication. J Mol Cell Biol, 2011, 3: 81-90??
[9]  27 Dali-Youcef N, Mataki C, Coste A, et al. Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proc Natl Acad Sci USA, 2007, 104: 10703-10708??
[10]  29 Pessler-Cohen D, Pekala P H, Kovsan J, et al. GLUT4 repression in response to oxidative stress is associated with reciprocal alterations in C/EBP alpha and delta isoforms in 3T3-L1 adipocytes. Arch Physiol Biochem, 2006, 112: 3-12??
[11]  30 Chiarugi P. The redox regulation of LMW-PTP during cell proliferation or growth inhibition. IUBMB Life, 2001, 52: 55-59 ??
[12]  31 Xu J, Liao K. Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem, 2004, 279: 35914-35922 ??
[13]  32 Tomlinson J J, Boudreau A, Wu D, et al. Modulation of early human preadipocyte differentiation by glucocorticoids. Endocrinology, 2006, 147: 5284-5293 ??
[14]  33 Gummersbach C, Hemmrich K, KronckeK D, et al. New aspects of adipogenesis: Radicals and oxidative stress. Differentiation, 2009, 77: 115-120??
[15]  36 White U A, Stephens J M. Transcriptional factors that promote formation of white adipose tissue. Mol Cell Endocri, 2010, 318: 10-14??
[16]  39 Lee E K, Lee M J, Abdelmohsen K, et al. miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor {gamma}expression. Mol Cell Biol, 2011, 31: 626-638??
[17]  41 Tang Q Q, Otto T C, Lane M D. Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc Natl Acad Sci USA, 2003, 100: 44-49??
[18]  42 Zhang K M, Guo W, Yang Y, et al. JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription. J Cell Biochem, 2011, 112: 488-497??
[19]  43 Pei H J, Yao Y, Yang Y, et al. Krüppel-like factor KLF9 regulates PPARgamma transactivation at the middle stage of adipogenesis. Cell Death Differ, 2011, 18: 315-327??
[20]  44 Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metab, 2008, 7: 339-347??
[21]  45 Oishi Y, Manabe I, Tobe K, et al. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab, 2005, 1: 27-39??
[22]  46 Banerjee S S, Feinberg M W, Watanabe M, et al. The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J Biol Chem, 2003, 278: 2581-2584??
[23]  47 Sue N, Jack B H, Eaton S A, et al. Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol Cell Biol, 2008, 28: 3967-3978??
[24]  50 Rosen E D, Spiegelman B M. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol, 2000, 16: 145-171??
[25]  51 Li F T, Long T, Lu Y, et al. The yeast cell-cycle network is robustly designed. Proc Natl Acad Sci USA, 2004, 101: 4781-4786??
[26]  17 Batt D B, Roberts T M. Cell density modulates protein-tyrosine phosphorylation. J Biol Chem, 1998, 273: 3408-3414??
[27]  18 Sorby M, Ostman A. Protein-tyrosine phosphatase-mediated decrease of epidermal growth factor and platelet-derived growth factor receptor tyrosine phosphorylation in high cell density cultures. J Biol Chem, 1996, 271: 10963-10966??
[28]  19 Zhao B, Wei X, Li W. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev, 2007, 21: 2747-2761??
[29]  20 Rosen E D, MacDougald O A. Adipocyte differentiation from the inside out. Nature Rev Mol Cell Biol, 2006, 7: 885-896
[30]  1 Zhu L, Skoultch A I. Coordinating cell proliferation and differentiation. Cur Opin Genet Dev, 2001, 10: 91-97
[31]  2 Buttitta L A, Edgar B A. Mechanisms controlling cell cycle exit upon terminal differentiation. Cur Opin Cell Biol, 2007, 19: 697-704??
[32]  6 Scott R E, Hoerl B J, Wille J J Jr, et al. Coupling of proadipocyte growth arrest and differentiation II. A cell cycle model for the physiological control of cell proliferation. J Cell Biol, 1982, 94: 400-405??
[33]  7 Pairault J, Green H. A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker. Proc Natl Acad Sci USA, 1979, 76: 5138-5142??
[34]  9 Musri M M, Gomis R, Párrizas M A. chromatin perspective of adipogenesis. Organogenesis, 2010, 6: 15-23??
[35]  10 Qiu Z, Wei Y, Chen N, et al. DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocytes differentiation into adipocytes. J Biol Chem, 2001, 276: 11988-11995??
[36]  12 Yoo E J, Chung J J, Choe S S, et al. Down-regulation of histone deacetylases stimulates adipocyte differentiation. J Biol Chem, 2006, 281: 6608-6615??
[37]  14 Fajas L, Egler V, Reiter R, et al. The retinoblastoma-histone deacetylase 3 complex inhibits PPARγ and adipocyte differentiation. Dev Cell, 2002, 3: 903-910??
[38]  16 Fagotto F, Gumbiner B M. Cell contact-dependent signaling. Dev Biol, 1996, 180: 445-454??
[39]  21 McKnight S L. On getting there from here. Science, 2010, 330: 1338-1339??
[40]  22 Hong C, Tontonoz P. Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Cur Opin Genet Dev, 2008, 18: 461-467??
[41]  23 DeBerardinis R J, Lum J J, Hatzivassiliou G, et al. The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab, 2008, 7: 11-20??
[42]  24 Teperino R, Schoonjans K, Auwerx J. Histone methyl transferases and demethylases: Can they link metabolism and transcription? Cell Metab, 2010, 12: 321-327
[43]  25 Wellen K E, Hatzivassiliou G, Sachdeva U M. ATP-citrate lyase links cellular metabolism to histone acetylation. Science, 2009, 324: 1076-1080??
[44]  28 Pani G, Colavitti R, Bedogni B, et al. A redox signaling mechanism for density-dependent inhibition of cell growth. J Biol Chem, 2000, 275: 38891-38899??
[45]  34 Deng J, Hua K, Lesser S S, et al. Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1. Adipogenesis Endocri, 2000, 141: 2370-2376
[46]  35 Hwang C S, Loftus T M, Mandrup S, et al. Adipocyte differentiation and leptin expression. Annu Rev Cell Dev Biol, 1997, 13: 231-259??
[47]  37 Musri M M, Gomis R, Párrizas M. Chromatin and chromatin-modifying proteins in adipogenesis. Biochem Cell Biol, 2007, 85: 397-410??
[48]  38 Wang Q, Li Y C, Wang J, et al. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci USA, 2008, 105: 2889-2894??
[49]  40 Louet J F, O’Malley B W. Coregulators in adipogenesis: What could we learn from the SRC (p160) coactivator family? Cell Cycle, 2007, 6: 2448-2452
[50]  48 Mori T, Sakaue H, Iguchi H, et al. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem, 2005, 280: 12867-12875
[51]  49 Tontonoz P, Hu E, Spiegelman B M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell, 1994, 79: 1147-1156??

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