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科学通报  2011 

BAP31在结直肠癌中的表达及临床意义

, PP. 1629-1634

Keywords: BAP31,结直肠癌,组织芯片,免疫组化

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Abstract:

采用组织芯片技术和免疫组织化学染色法检测B细胞受体相关蛋白31(Bcellreceptorassociatedprotein31,BAP31)在120例结直肠癌组织及其配对远端正常组织中的表达情况,并分析其与临床病理特征之间的关系.结果显示,BAP31主要定位于胞浆,正常黏膜上皮呈阴性或弱阳性表达.在结直肠癌组织中阳性表达率为64.17%,明显高于正常黏膜上皮中的6.67%,差异具有统计学意义(P=0.000).BAP31阴性表达与结直肠癌的低分化程度(P=0.001)及远处转移相关(P=0.036).BAP31阴性患者总体生存率明显低于阳性患者(P=0.003).因此,BAP31可能是判断结直肠癌预后的潜在指标,并与肿瘤的侵袭性行为有关.

References

[1]  2 Winawer S J. Colorectal cancer screening. Best Pract Res Clin Gastroenterol, 2007, 21: 1031-1048??
[2]  3 Jema A, Siegel R, Ward E, et al. Cancer statistics 2009. CA Cancer J Clin, 2009, 59: 225-249??
[3]  11 Madeo F, Durchschlag M, Kepp O, et al. Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast tomammals. Cell Cycle, 2009, 8: 639-642??
[4]  13 Panaretakis T, Kepp O, Brockmeier U, et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J,2009, 28: 578-590??
[5]  14 Watson A J. Apoptosis and colorectal cancer. Gut, 2004, 53: 1701-1709??
[6]  15 Marshman E, Ottewell P D, Potten C S, et al. Caspase activation during spontaneous and radiation-induced apoptosis in the murineintestine. J Pathol, 2001, 195: 285-292??
[7]  16 Remmele W, Stegner H E. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogenreceptor detection (ER-ICA) in breast cancer tissue. Der Pathologe, 1987, 8: 138-140
[8]  17 Magerla C, Ellinger J, Braunschweig T, et al. H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliaryand gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1. Hum Pathol, 2010, 41:181-189??
[9]  20 Manley H A, Lennon V A. Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons anddiscrete endocrine cells. J Histochem Cytochem, 2001, 49: 1235-1244??
[10]  21 Wang B, Nguyen M, Breckenridge D G, et al. Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is aninhibitor of Fas-initiated release of cytochromec from mitochondria. J Biol Chem, 2003, 278: 14461-14468??
[11]  22 Nieto-Miguel T, Fonteriz R I, Vay L, et al. Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.Cancer Res, 2007, 67: 10368-10378??
[12]  23 Mosser J, Sarde C O, Vicaire S, et al. A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to theadrenoleukodystrophy gene. Genomics, 1994, 22: 469-471
[13]  1 Jemal A, Siegel R, Ward E, et al. Cancer statistic 2008. CA Cancer J Clin, 2008, 58: 71-96??
[14]  4 Wolpin B, Meyerhardt J, Mamon H, et al. Adjuvant treatment of colorectal cancer. CA Cancer J Clin, 2007, 57: 168-185??
[15]  5 Zhang Y, Ye Y, Shen D, et al. Identification of transgelin-2 as a biomarker of colorectal cancer by laser capture microdissection andquantitative proteome analysis. Cancer Sci, 2010, 101: 523-529??
[16]  6 Kim K M, Adachi T, Nielsen P J, et al. Two new proteins preferentially associated with membrane immunoglobulin D. EMBO J, 1994, 13:3793-3800
[17]  7 Annaert W G, Becker B, Kistner U, et al. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J Cell Biol, 1997,139: 1397-1410??
[18]  8 Breckenridge D G, Stojanovic M, Marcellus R C, et al. Caspase cleavage product of BAP31 induces mitochondrial fission throughendoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol, 2003, 160: 1115-1127??
[19]  9 Chandra D, Choy G, Deng X, et al. Association of active caspase 8 with the mitochondrial membrane during apoptosis: Potential roles incleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death. Mol CellBiol, 2004, 24: 6592-6607
[20]  10 Nguyen M, Breckenridge D G, Ducret A, et al. Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation andrelease of cytochrome c from mitochondria. Mol Cell Biol, 2000, 20: 6731-6740??
[21]  12 Delom F, Emadali A, Cocolakis E, et al. Calnexin-dependent regulation of tunicamycininduced apoptosis in breast carcinoma MCF-7 cells.Cell Death Differ, 2007, 14: 586-596??
[22]  18 Adachi T, Schamel W W, Kim K M, et al. The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29lies in the IgD transmembrane sequence. EMBO J, 1996, 15: 1534-1541
[23]  19 Ladasky J J, Boyle S, Seth M, et al. Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHCmolecules. J Immunol, 2006, 177: 6172-6181

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