全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
科学通报  2011 

基因重复在基因选配(geneco-option)过程中的重要作用:对motilin/ghrelin荷尔蒙基因家族及其受体基因家族的进化研究

, PP. 1726-1733

Keywords: ghrelin,motilin,基因家族,配体,受体,协同进化,基因间相互作用

Full-Text   Cite this paper   Add to My Lib

Abstract:

原先存在的基因经过一些改良可能获得新的属性从而承担新的功能.在分子遗传的层次,这个过程通常伴随基因重复以及基因重复后旁系同源基因的功能分化.本研究探索了基因重复后荷尔蒙、受体间特异性相互作用的演化形成.尽管对这个问题已有相关研究报道,但针对更多个案的研究能帮助我们更好地理解此前已经提出的进化模型的普遍性,可能还有助于发现新的进化模式.基于生物信息学的手段,结合比较基因组学、系统发育学的方法,本研究揭示,ghrelin前体基因和motilin前体基因是由一个祖先基因重复而来,基因重复发生在羊膜动物与两栖动物刚刚分歧之后.与此形成鲜明对照,它们各自的特异性受体却呈现了很不一样的进化历史.GPR39最先分化出来,而后一个祖先基因经连续的基因重复分化为鱼类特异的进化支A,GHSR和MLNR,基因重复发生在射线鳍鱼(ray-finnedfish)与四足动物分化之前.ghrelin/GHSR信号系统的功能从鱼类到哺乳动物的进化过程中始终保守.motilin-MLNR之间的特异性相互作用是荷尔蒙基因重复后,MLN与GHRL基因分化之后,在羊膜动物世系中配体与受体协同进化而形成的.该结果提示,在分子水平上,基于保守的分子元件,新的神经内分泌响应模式能够通过基因重复后的基因选配过程形成.基因重复既节俭又极具创造力,为生物多样性的演化提供了物质基础.

References

[1]  3 True J R, Carroll S B. Gene co-option in physiological and morphological evolution. Annu Rev Cell Dev Biol, 2002, 18: 53-80??
[2]  4 Khersonsky O, Roodveldt C, Tawfik D S. Enzyme promiscuity: Evolutionary and mechanistic aspects. Curr Opin Chem Biol, 2006, 10:498-508??
[3]  5 Tokuriki N, Tawfik D S. Protein dynamism and evolvability. Science, 2009, 324: 203-207??
[4]  6 Peeters T L. Ghrelin: A new player in the control of gastrointestinal functions. Gut, 2005, 54: 1638-1649??
[5]  7 Murray C D, Kamm M A, Bloom S R, et al. Ghrelin for the gastroenterologist: History and potential. Gastroenterology, 2003, 125:1492-1502??
[6]  8 Walsh J H, Dockaray G J. Gut Peptides: Biochemistry and Physiology. New York: Raven Press, 1993. 261-303
[7]  10 Feighner S D, Tan C P, McKee K K, et al. Receptor for motilin identified in the human gastrointestinal system. Science, 1999, 284:2184-2188??
[8]  11 Holst B, Holliday N D, Bach A, et al. Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem, 2004,279: 53806-53817??
[9]  12 Altschul S F, Madden T L, Schaffer A A, et al. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs.Nucleic Acids Res, 1997, 25: 3389-3402??
[10]  14 Tusnady G E, Simon I. The HMMTOP transmembrane topology prediction server. Bioinformatics, 2001, 17: 849-850??
[11]  15 Murphy W J, Eizirik E, O’Brien S J, et al. Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science,2001, 294: 2348-2351??
[12]  16 van Rheede T, Bastiaans T, Boone D N, et al. The platypus is in its place: Nuclear genes and indels confirm the sister group relation ofmonotremes and Therians. Mol Biol Evol, 2006, 23: 587-597
[13]  17 Hedges S B, Kumar S. Genomic clocks and evolutionary timescales. Trends Genet, 2003, 19: 200-206??
[14]  18 Hayasaka K, Fujii K, Horai S. Molecular phylogeny of macaques: Implications of nucleotide sequences from an 896-base pair region ofmitochondrial DNA. Mol Biol Evol, 1996, 13: 1044-1053
[15]  19 Springer M S, Murphy W J, Eizirik E, et al. Placental mammal diversification and the Cretaceous-Tertiary boundary. Proc Natl Acad SciUSA, 2003, 100: 1056-1061??
[16]  20 Thompson J D, Higgins D G, Gibson T J. ClustalW: Improving the sensitivity of progressive multiple sequence alignment throughsequence weighting, position specific gap penalties and weight matrix choice. Nucleic Acids Res, 1994, 22: 4673-4680??
[17]  21 Felsenstein J. PHYLIP (Phylogeny Inference Package) version 3.5c. Distributed by the author. Department of Genetics, University ofWashington, Seattle. 1993
[18]  24 Standfuss J, Xie G, Edwards P C, et al. Crystal structure of a thermally stable rhodopsin mutant. J Mol Biol, 2007, 372: 1179-1188??
[19]  25 Murakami M, Kouyama T. Crystal structure of squid rhodopsin. Nature, 2008, 453: 363-367??
[20]  26 Sayle R A, Milner-White E J. RASMOL: Biomolecular graphics for all. Trends Biochem Sci, 1995, 20: 374??
[21]  29 Chan C B, Cheng C H. Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptortranscripts from the pituitary of black seabream Acanthopagrus schlegeli. Mol Cell Endocrinol, 2004, 214: 81-95??
[22]  35 Fryxell K J. The coevolution of gene family trees. Trends Genet, 1996, 12: 364-369
[23]  38 Kaiya H, Kojima M, Hosoda H, et al. Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia,Oreochromis mossambicus. Comp Biochem Physiol B Biochem Mol Biol, 2003, 135: 421-429??
[24]  41 Ohno S. Evolution by Gene Duplication. New York: Springer, 1970
[25]  42 Kondrashov F A. In search of the limits of evolution. Nat Genet, 2005, 37: 73-76
[26]  1 Darwin C. On the Various Contrivances by Which British and Foreign Orchids Are Fertilized by Insects and on the Good Effects ofIntercrossing. London: Murray, 1886
[27]  2 Jacob F. Evolution and tinkering. Science, 1977, 196: 1161-1166??
[28]  9 Samson W K, Lumpkin M D, Nilaver G, et al. Motilin: A novel growth hormone releasing agent. Brain Res Bull, 1984, 12: 57-62??
[29]  13 Birney E, Clamp M, Durbin R. GeneWise and genomewise. Genome Res, 2004, 14: 988-995??
[30]  22 Yang Z. PAML: A program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci, 1997, 13: 555-556
[31]  23 Warne T, Serrano-Vega M J, Baker J G, et al. Structure of a beta1-adrenergic G-protein-coupled receptor. Nature, 2008, 454: 486-491??
[32]  27 Roch G J, Wu S, Sherwood N M. Hormones and receptors in fish: Do duplicates matter? Gen Comp Endocrinol, 2009, 161: 3-12
[33]  28 Taylor J S, Braasch I, Frickey T, et al. Genome duplication, a trait shared by 22000 species of ray-finned fish. Genome Res, 2003, 13: 382-390
[34]  30 Palyha O C, Feighner S D, Tan C P, et al. Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor(GHS-R) conserved from Pufferfish to humans. Mol Endocrinol, 2000, 14: 160-169??
[35]  31 Zhang J V, Ren P G, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake.Science, 2005, 310: 996-999??
[36]  32 Kaiya H, Kojima M, Hosoda H, et al. Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J Biol Chem, 2001, 276:40441-40448??
[37]  33 Matsuura B, Dong M, Miller L J. Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. Criticalrole of second extracellular loop for peptide binding and action. J Biol Chem, 2002, 277: 9834-9839??
[38]  34 Gether U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev, 2000, 21: 90-113??
[39]  36 Irwin D M. Evolution of hormone function: Proglucagon-derived peptides and their receptors. BioScience, 2005, 55: 583-591??
[40]  37 Kaiya H, Kojima M, Hosoda H, et al. Amidated fish ghrelin: Purification, cDNA cloning in the Japanese eel and its biological activity. JEndocrinol, 2003, 176: 415-423??
[41]  39 Unniappan S, Lin X, Cervini L, et al. Goldfish ghrelin: Molecular characterization of the complementary deoxyribonucleic acid, partialgene structure and evidence for its stimulatory role in food intake. Endocrinology, 2002, 143: 4143-4146??
[42]  40 Bridgham J T, Carroll S M, Thornton J W. Evolution of hormone-receptor complexity by molecular exploitation. Science, 2006, 312:97-101??

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133