1 Mukherjee B, Choy H, Nirodi C. Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: Rationaleand strategies for radiosensitization. Semin Radiat Oncol, 2010, 20: 250-257？？
[2]
13 Shintani S, Li C, Mihara M, et al. Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), anepidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oralcancer. Int J Cancer, 2003, 107: 1030-1037
[3]
14 Tanaka T, Munshi A, Brooks C, et al. Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repaircapacity. Clin Cancer Res, 2008, 14: 1266-1273？？
[4]
15 Das A K, Chen B P, Story M D, et al. Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR)abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. Cancer Res, 2007, 67: 5267-5274？？
[5]
16 Mukherjee B, McEllin B, Camacho C V. EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance inglioblastoma. Cancer Res, 2009, 69: 4252-4259？？
[6]
17 Toulany M, Kehlbach R, Florczak U, et al. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibitingDNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Ther, 2008, 7: 1772-1781？？
[7]
18 Golding S E, Morgan R N, Adams B R. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNAdouble-strand break repair in human glioma cells. Cancer Biol Ther, 2009, 8: 730-738？？
[8]
19 Bozulic L, Surucu B, Hynx D, et al. PKBa/Akt1 acts downstream of DNA-PK in the DNA double strand break response and promotessurvival. Mol Cell, 2008, 30: 203-213？？
[9]
20 Chen B P, Uematsu N, Kobayashi J, et al. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at theThr-2609 cluster upon DNA double strand break. J Biol Chem, 2007, 282: 6582-6587
[10]
22 Toulany M, Baumann M, Rodemann H P. Stimulated PI3K-Akt signaling mediated through ligand or radiation-induced EGFR dependsindirectly, but not directly, on constitutive K-ras activity. Mol Cancer Res, 2007, 5: 863-872？？
[11]
26 Nyati M K, Feng F Y, Maheshwari D, et al. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase1/2 via activation of MKP-1in response to radiation. Cancer Res, 2006, 66: 11554-11559？？
[12]
27 Li L P, Wang H, Eddy S, et al. Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancercells. Cancer Res, 2008, 68: 9141-9146？？
[13]
28 Wang S C, Nakajima Y, Yu Y L, et al. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol, 2006, 8:1359-1368？？
[14]
2 David J C, Chaitanya S N. The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage. Clin Cancer Res,2007, 13: 6555-6560？？
[15]
3 Dittmann K, Mayer C, Rodemann1 H P. Nuclear EGFR as novel therapeutic target. Insights into nuclear translocation and function.Strahlenther Onkol, 2010, 186: 1-6
[16]
4 Tao Y G, Song X, Deng X Y, et al. Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage byEpstein-Barr-encoded oncoprotein latent membrane protein 1. Exp Cell Res, 2005, 303: 240-251？？
[17]
5 Szumiel I. Epidermal growth factor receptor and DNA double strand break repair: The cell’s self-defence. Cell Signal, 2006, 18:1537-1548？？
[18]
6 Dittmann K, Mayer C, Kehlbach R, et al. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFRtransport and activation of DNA-PK. Mol Cancer, 2008, 7: 69-78？？
[19]
7 Dittmann K, Mayer C, Fehrenbacher B, et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation ofDNA-dependent protein kinase. J Biol Chem, 2005, 280: 31182-31189？？
[20]
8 Liccardi G, Hartley J A, Hochhauser D. EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiationtreatment. Cancer Res, 2011, 71: 1-12
[21]
9 Wang Y N, Yamaguchi H, Hsu J M. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene,2010, 29: 3997-4006？？
[22]
10 Kriegs M, Kasten-Pisula U, Rieckmann T. The epidermal growth factor receptor modulates DNA double-strand break repair by regulatingnon-homologous end-joining. DNA Repair, 2010, 9: 889-897？？
[23]
11 Bandyopadhyay D, Mandal M, Adam L, et al. Physical interaction between epidermal growth factor receptor and DNA-dependent proteinkinase in mammalian cells. J Biol Chem, 1998, 273: 1568-1573？？
[24]
12 Hsu S C, Miller S A, Wang Y. Nuclear EGFR is required for cisplatin resistance and DNA repair. Am J Transl Res, 2009, 1: 249-258
[25]
21 Weidhaas J B, Eisenmann D M, Justin M, et al. A conserved RAS/mitogen-activated protein kinase pathway regulates DNA damage-induced cell death postirradiation in radelegans. Cancer Res, 2006, 66: 10434-10438？？
[26]
23 Toulany M, Kasten-Pisula U, Brammer I. Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signalingincreases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clin Cancer Res, 2006, 12: 4119-4126？？
[27]
24 Meyn R E, Munshi A, Haymach J V. Receptor signaling as a regulatory mechanism of DNA repair. Radiother Oncol, 2009, 92: 316-322？？
[28]
25 Golding S E, Rosenberg E, Neill S, et al. Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated,homologous recombination repair, and the DNA damage response. Cancer Res, 2007, 67: 1046-1053？？
