3 Drouin G, Godin J R, Pagé B. The genetics of vitamin C loss in vertebrates. Curr Genomics, 2011, 12: 371-378
[2]
4 Monfort A, Wutz A. Breathing-in epigenetic change with vitamin C. EMBO Rep, 2013, 14: 337-346
[3]
5 Roy R N, Guha B C. Species difference in regard to the biosynthesis of ascorbic acid. Nature, 1958, 182: 319-320
[4]
6 Smirnoff N. Vc booster. Nat Biotechnol, 2003, 21: 134-136
[5]
7 Robertson W B, Schwartz B. Ascorbic acid and the formation of collagen. J Biol Chem, 1953, 201: 689-696
[6]
18 Gu T P, Guo F, Yang H, et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature, 2011, 477: 606-610
[7]
20 Yin R, Mao S-Q, Zhao B, et al. Ascorbic acid enhances tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc, 2013, 135: 10396-10403
[8]
21 Chung T L, Brena R M, Kolle G, et al. Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells, 2010, 28: 1848-1855
[9]
22 Blaschke K, Ebata K, Karimi M, et al. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature, 2013, 500: 222-226
[10]
23 Wu H, Wu Y, Ai Z, et al. Vitamin C enhances nanog expression via activation of the Jak/STAT signaling pathway. Stem Cells, 2014, 32: 166-176
[11]
27 Falnes P, Johansen R, Seeberg E. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature, 2002, 419: 178-182
[12]
28 Trewick S, Henshaw T, Hausinger R, et al. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature, 2002, 419: 174-178
[13]
29 Yang C-G, Yi C, Duguid E, et al. Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature, 2008, 452: 961-965
[14]
30 Han Z, Niu T, Chang J, et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature, 2010, 464: 1205-1209
[15]
31 Jia G, Fu Y, Zhao X, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol, 2011, 7: 885-887
[16]
32 Esteban M, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 2010, 6: 71-79
[17]
33 Wang T, Chen K, Zeng X, et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell, 2011, 9: 575-587
[18]
34 Stadtfeld M, Apostolou E, Ferrari F, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet, 2012, 44: 398-405
[19]
35 Stadtfeld M, Apostolou E, Akutsu H, et al. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature, 2010, 465: 175-181
[20]
38 Costa Y, Ding J, Theunissen T W, et al. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature, 2013, 495: 370-374
[21]
39 Gao Y, Chen J, Li K, et al. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell, 2013, 12: 453-469
[22]
1 Szent-Gyorgyi A. Observations on the function of peroxidase systems and the chemistry of the adrenal cortex: Description of a new carbohydrate derivative. Biochem J, 1928, 22: 1387-1409
[23]
2 Szent-Gyorgyi A, Haworth W N. ‘Hexuronic acid' (ascorbic acid) as the antiscorbutic factor. Nature, 1933, 131: 24
[24]
8 Rice M E. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci, 2000, 23: 209-216
[25]
9 Podmore I D, Griffiths H R, Herbert K E, et al. Vc exhibits pro-oxident properties. Nature, 1998, 392: 559
[26]
10 Knowles H J, Raval R R, Harris A L. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res, 2003, 23: 1764-1768
[27]
11 Tsukaguchi H, Tokui T, Machenzie B, et al. A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature, 1999, 399: 70-75
[28]
12 Hediger M. New view at C. Nat Med, 2002, 8: 445-446
[29]
13 Sotiria S, Suzana G, Jun C, et al. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med, 2002, 8: 514-517
[30]
14 Upadhyay A K, Horton J R, Zhang X, et al. Coordinated methyl-lysine erasure: Structural and functional linkage of a Jumonji demethylase domain and a reader domain. Curr Opin Struct Biol, 2011, 21: 750-760
[31]
15 Tahiliani M, Koh K P, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science, 2009, 324: 930-935
[32]
16 Ito S, Shen L, Dai Q, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science, 2011, 333: 1300-1303
[33]
17 He Y-F, Li B-Z, Li Z, et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science, 2011, 333: 1303-1307
[34]
19 Hackett J A, Sengupta R, Zylicz J J, et al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science, 2013, 339: 448-452
[35]
24 Gao Y, Yang L, Chen L, et al. Vitamin C facilitates pluripotent stem cell maintenance by promoting pluripotency gene transcription. Biochimie, 2013, 95: 2107-2113
[36]
25 Comes S, Gagliardi M, Laprano N, et al. L-proline induces a mesenchymal-like invasive program in embryonic stem cells by remodeling H3K9 and H3K36 methylation. Stem Cell Reports, 2013, 1: 307-321
[37]
26 Minor E A, Court B L, Young J I, et al. Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem, 2013, 288: 13669-13674
[38]
36 Chen J, Liu H, Liu J, et al. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2013, 45: 34-42
[39]
37 Doege C A, Inoue K, Yamashita T, et al. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature, 2012, 488: 652-655
[40]
40 Chen J, Guo L, Zhang L, et al. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet, 2013, 45: 1504-1509
[41]
41 Yoshida Y, Takahashi K, Okita K, et al. Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell, 2009, 5: 237-241
[42]
42 Mathieu J, Zhou W, Xing Y, et al. Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency. Cell Stem Cell, 2014, 14: 592-605