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科学通报  2014 

分选链接蛋白家族研究进展

DOI: 10.1360/N972014-00042, PP. 3442-3449

Keywords: 分选链接蛋白,细胞内吞,胞内分选,胞内信号转导,疾病

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Abstract:

分选链接蛋白(sortingnexins,SNXs)是一类含有吞噬细胞氧化酶同源性结构域(Phox-homologydomain,PXdomain)蛋白的统称,在哺乳动物中有33个成员,其PX结构域易与定位于早期内涵体的磷脂酰肌醇-3-磷酸(phosphatidylinositol-3-phosphatePtdIns(3)P)结合,参与蛋白跨膜过程中货物分子接头蛋白与膜锚定蛋白的结合等蛋白间的相互作用,故SNXs在细胞内吞、蛋白分选、细胞信号转导、膜运输、膜重塑和细胞器运动等方面均起重要作用.不同SNXs尚含差别较大的其他结构域,据差异结构域的不同,可进一步分为3大类.其中某些成员参与肿瘤、阿尔茨海默症、神经疾病和心脏病等人类重大疾病的发生.本文概述其发现、基因定位、结构、分类、功能及相关疾病等的研究现状,并展望其相关动向.

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