全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
科学通报  2011 

miRNA与鼻咽癌发病机制

, PP. 9-15

Keywords: miRNA,鼻咽癌,EBV,LMP1,信号转导通路,有丝分裂,侵袭转移

Full-Text   Cite this paper   Add to My Lib

Abstract:

miRNA(microRNA)是一族由22~25个核苷酸组成的非编码RNA小分子,它通过与靶mRNA的3'-非编码区以碱基互补配对的方式结合,实现对靶基因转录后水平的降解或抑制.最新研究表明,miRNA与鼻咽癌中EBV,LMP1,信号转导通路,肿瘤相关基因网络,细胞有丝分裂,肿瘤血管生成和侵袭转移密切相关.因此,探索miRNA与鼻咽癌发生发展之间的关系,有助于加深对其发病机制的认识,也将为临床诊断和治疗提供新的启示与依据.

References

[1]  47. Xiao B, Fan S, Zeng Z, et al. Purification of novel UBAP1 protein and its decreased expression on nasopharyngeal carcinoma tissue microarray. Protein Expr Purif, 2006, 47: 60-67?
[2]  48. Chalhoub N, Baker S J. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol, 2009, 4: 127-150?
[3]  49. Shen G P, Pan Q H, Hong M H, et al. Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy cantonese. Int J Cancer, 2010
[4]  51. Guo Y, Chen J X, Yang S, et al. Selection of reliable reference genes for gene expression study in nasopharyngeal carcinoma. Acta Pharmacol Sin, 2010, 31: 1487-1494?
[5]  52. Xu Y F, Liu W L, Dong J Q, et al. Sequencing of DC-SIGN promoter indicates an association between promoter variation and risk of nasopharyngeal carcinoma in Cantonese. BMC Med Genet, 2010
[6]  53. Wang S, Xiao X, Zhou X, et al. TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma. BMC Cancer, 2010
[7]  57. Jang Y J, Ji J H, Choi Y C, et al. Regulation of Polo-like kinase 1 by DNA damage in mitosis: Inhibition of mitotic PLK-1 by protein phosphatase 2A. J Biol Chem, 2007, 282: 2473-2482?
[8]  59. Syljuasen R G, Jensen S, Bartek J, et al. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res, 2006, 66: 10253-10257?
[9]  60. Spankuch B, Kurunci-Csacsko E, Kaufmann M, et al. Rational combinations of siRNAs targeting Plk1 with breast cancer drugs. Oncogene, 2007, 26: 5793-5807?
[10]  61. Su S F, Han F, Zhao C, et al. Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone. Int J Radiat Oncol Biol Phys, 2010
[11]  63. Shai E, Varon D. Development, cell differentiation, angiogenesis—Microparticles and their roles in angiogenesis. Arterioscler Thromb Vasc Biol, 2011, 31: 10-14?
[12]  64. Lv X, Xiang Y Q, Cao S M, et al. Prospective validation of the prognostic value of elevated serum vascular endothelial growth factor in patients with nasopharyngeal carcinoma: More distant metastases and shorter overall survival after treatment. Head Neck, 2010
[13]  65. Hua Z, Lv Q, Ye W B, et al. MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One, 2006, 1: e116?
[14]  68. Chew M M, Gan S Y, Khoo A S, et al. Interleukins, laminin and Epstein-Barr virus latent membrane protein 1 (EBV LMP1) promote metastatic phenotype in nasopharyngeal carcinoma. BMC Cancer, 2010, 10: 574
[15]  71. Xia H, Ng S S, Jiang S, et al. MiR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion. Biochem Biophys Res Commun, 2010, 391: 535-541?
[16]  2. Chin D, Boyle G M, Porceddu S, et al. Head and neck cancer: Past, present and future. Expert Rev Anticancer Ther, 2006, 6: 1111-1118?
[17]  3. Deyrup A T. Epstein-Barr virus-associated epithelial and mesenchymal neoplasms. Hum Pathol, 2008, 39: 473-483?
[18]  4. Zhu J Y, Pfuhl T, Motsch N, et al. Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. J Virol, 2009, 83: 3333-3341?
[19]  5. Georgia S. Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA, 2009, 15: 1443-1461?
[20]  6. Filipowicz W, Bhattacharyya S N, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet, 2008, 9: 102-114
[21]  10. Wu M, Jolicoeur N, Li Z, et al. Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis, 2008, 29: 1710-1716?
[22]  11. Kumar M S, Lu J, Mercer K L, et al. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genet, 2007, 39: 673-677?
[23]  15. Finoux A L, Chartrand P. Oncogenic and tumour suppressor microRNAs. Med Sci (Paris), 2008, 24: 1049-1054
[24]  16. Wang X, Tang S, Le S Y, et al. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One, 2008, 3: e2557?
[25]  19. Takakura S, Mitsutake N, Nakashima M, et al. Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells. Cancer Sci, 2008, 99: 1147-1154?
[26]  20. Welch C, Chen Y, Stallings R L. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene, 2007, 26: 5017-5022?
[27]  21. Douglas R H. Metastamir: The field of metastasis-regulatory microRNA is spreading. Cancer Res, 2009, 69: 7495-7498?
[28]  22. Cosmopoulos K, Pegtel M, Hawkins J, et al. Comprehensive profiling of Epstein-Barr virus microRNAs in nasopharyngeal carcinoma. J Virol, 2009, 83: 2357-2367?
[29]  23. Griffiths-Jones S, Saini H K, van Dongen S, et al. miRBase: Tools for microRNA genomics. Nucleic Acids Res, 2008, 36: D154-D158?
[30]  24. Gourzones C, Gelin A, Bombik I, et al. Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells. Virol J, 2010, 7: 271?
[31]  28. Cullen B R. Viral and cellular messenger RNA targets of viral microRNAs. Nature, 2009, 457: 421-425?
[32]  30. Choy E Y, Siu K L, Kok K H, et al. An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival. J Exp Med, 2008, 205: 2551-2560?
[33]  32. Chang L K, Chuang J Y, Nakao M, et al. MCAF1 and synergistic activation of the transcription of Epstein-Barr virus lytic genes by Rta and Zta. Nucleic Acids Res, 2010, 38: 4687-4700?
[34]  33. Hariwiyanto B, Sastrowiyoto S, Mubarika S, et al. LMP1 and LMP2 may be prognostic factors for outcome of therapy in nasopharyngeal cancers in Indonesia. Asian Pac J Cancer Prev, 2010, 11: 763-766
[35]  34. Natalie M, Thorsten P, Jan M, et al. Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol, 2007, 4: 131-137
[36]  36. Graziana G, Annalisa R, Daniela R, et al. Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-κB pathway. Nucleic Acids Res, 2008, 36: 6608-6619?
[37]  37. Lo A K, To K F, Lo K W, et al. Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci USA, 2007, 104: 16164-16169?
[38]  38. Zheng H, Li L L, Hu D S, et al. Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol, 2007, 4: 185-196
[39]  40. Chen H C, Chen G H, Chen Y H, et al. MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer, 2009, 100: 1002-1011?
[40]  41. Li Y H, Hu C F, Shao Q, et al. Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. J Transl Med, 2008, 6: 1?
[41]  42. Pan J, Kong L, Lin S, et al. The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma. Laryngoscope, 2008, 118: 1970-1975?
[42]  43. Zeng Z Y, Zhou Y H, Zhang W L, et al. Gene expression profiling of nasopharyngeal carcinoma reveals the abnormally regulated Wnt signaling pathway. Hum Pathol, 2007, 38: 120-133?
[43]  1. George A C, Carlo M C. MicroRNA signatures in human cancers. Nat Rev Cancer, 2006, 6: 857-866?
[44]  7. Israel A, Sharan R, Ruppin E, et al. Increased microRNA activity in human cancers. PLoS One, 2009, 4: e6045?
[45]  8. Olson P, Lu J, Zhang H, et al. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev, 2009, 23: 2152-2165?
[46]  9. Zhang B, Pan X, Cobb G P, et al. MicroRNAs as oncogenes and tumor suppressors. Dev Biol, 2007, 302: 1-12?
[47]  12. Liu C G, Calin G A, Volinia S, et al. MicroRNA expression profiling using microarrays. Nat Protoc, 2008, 3: 563-578?
[48]  13. Hatfield S, Ruohola-Baker H. microRNA and stem cell function. Cell Tissue Res, 2008, 331: 57-66?
[49]  14. Bushati N, Cohen S M. microRNA functions. Annu Rev Cell Dev Biol, 2007, 23: 175-205?
[50]  17. Aurora E K, Frank J S. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer, 2006, 6: 259-269?
[51]  18. Rai D, Karanti S, Jung I, et al. Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma. Cancer Genet Cytogenet, 2008, 181: 8-15?
[52]  25. Jing Y Z, Wang Y, Jia Y P, et al. Polymorphisms of Epstein-Barr virus BHRF1 gene, a homologue of bcl-2. Chin J Cancer, 2010, 29: 1000-1005
[53]  26. Edwards R H, Marquitz A R, Raab-Traub N. Epstein-Barr virus BART microRNAs are produced from a large intron prior to splicing. J Virol, 2008, 82: 9094-9106?
[54]  27. Ghosh Z, Mallick B, Chakrabarti J. Cellular versus viral microRNAs in host-virus interaction. Nucleic Acids Res, 2009, 37: 1035-1048?
[55]  29. Xia T, O'Hara A, Araujo I, et al. EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3. Cancer Res, 2008, 68: 1436-1442?
[56]  31. Iizasa H, Wulff B E, Alla N R, et al. Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency. J Biol Chem, 2010, 285: 33358-33370?
[57]  35. Middeldorp J M, Pegtel D M. Multiple roles of LMP1 in Epstein-Barr virus induced immune escape. Semin Cancer Biol, 2008, 18: 388-396?
[58]  39. Liu Q, Fu H, Sun F, et al. miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res, 2008, 36: 5391-5404?
[59]  44. Zhang L M, Deng T, Li X Y, et al. MicroRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis, 2010, 31: 559-566?
[60]  45. Zhou H D, Li X L, Li G Y, et al. Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus. Mol Cell Biochem, 2008, 309: 191-197?
[61]  46. Nakada C, Matsuura K, Tsukamoto Y, et al. Genome-wide microRNA expression profiling in renal cell carcinoma: Significant down-regulation of miR-141 and miR-200c. J Pathol, 2008, 216: 418-427?
[62]  50. Ran Y, Wu S, You Y. Demethylation of E-cadherin gene in nasopharyngeal carcinoma could serve as a potential therapeutic strategy. J Biochem, 2010
[63]  54. Strebhardt K, Ullrich A. Targeting Polo-like kinase 1 for cancer therapy. Nat Rev Cancer, 2006, 6: 321-330?
[64]  55. Wei S, Nehad M A, Carlo B, et al. Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer. Int J Cancer, 2010, 126: 2036-2048
[65]  56. Liu X, Lei M, Erikson R L. Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol, 2006, 26: 2093-2108
[66]  58. Sun F, Mikuni S, Kinjo M. Monitoring the caspase cascade in single apoptotic cells using a three-color fluorescent protein substrate. Biochem Biophys Res Commun, 2010
[67]  62. Zhao L, Wan Q, Zhou Y, et al. The role of replanning in fractionated intensity modulated radiotherapy for nasopharyngeal carcinoma. Radiother Oncol, 2010
[68]  66. Olsson A K, Dimberg A, Kreuger J, et al. VEGF receptor signalling—in control of vascular function. Nat Rev Mol Cell Biol, 2006, 7: 359-371?
[69]  67. Li G, Wu Z R, Peng Y, et al. MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells. Cancer Lett, 2010, 299: 29-36?
[70]  69. Kim T J, Lee Y S, Kang J H, et al. Prognostic significance of expression of vegf and cox-2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 and EGFR. J Surg Oncol, 2010
[71]  70. Sikumar S, Johan A B, Chen I H, et al. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracelluar matrix proteins. Proc Natl Acad Sci USA, 2008, 105: 5874-5878?
[72]  72. Chen L C, Chen C C, Liang Y, et al. A novel role for TNFAIP2: Its correlation with invasion and metastasis in nasopharyngeal carcinoma. Mod Pathol, 2010

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133