3 Nel A E, Madler L, Velegol D, et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater, 2009, 8: 543-557？？
[2]
4 Samet J M, Dominici F, Curriero F C, et al. Fine particulate air pollution and mortality in 20 .s cities, 1987-1994. N Engl J Med, 2000, 343:1742-1749
[3]
6 Lee C H, Guo Y L, Tsai P J, et al. Fatal acute pulmonary oedema after inhalation of fumes from polytetrafluoroethylene (ptfe). Eur Respir J, 1997,10: 1408-1411？？
[4]
7 Song Y, Li X, Du X. Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma. Eur Respir J, 2009, 34: 559-567？？
[5]
8 Zhao Y L, Xing G M, Chai Z F. Nanotoxicology: Are carbon nanotubes safe? Nat Nanotechnol, 2008, 3: 191-192
[6]
11 Raloff J. Nano hazards. Sci News, 2005, 167: 179-179
[7]
12 Nel A, Xia T, Madler L, et al. Toxic potential of materials at the nanolevel. Science, 2006, 311: 622-627？？
[8]
13 Oberd.rster G, Oberd.rster E, Oberd.rster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ HealthPerspect, 2005, 113: 823-839
[9]
14 Zhang Y, Li B, Chen C Y, et al. Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice.BioMetals, 2009, 22: 251-259？？
[10]
15 Liu Y, Gao Y X, Zhang L L, et al. Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation inmice. J Nanosci Nanotechnol, 2009, 9: 1-9？？
[11]
17 Chen Z, Meng H, Yuan H, et al. Identification of target organs of copper nanoparticles with icp-ms technique. J Radioanal Nucl Chem, 2007, 272:599-603？？
[12]
18 Wang B, Feng W Y, Wang T C, et al. Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice. Toxicol Lett, 2006, 161:115-123？？
[13]
19 Chen Z, Meng H, Xing G M, et al. Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett, 2006, 163: 109-120？？
[14]
20 Meng H, Chen Z, Xing G M, et al. Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles. Toxicol Lett,2007, 175: 102-110？？
23 Wang J X, Chen C Y, Li Y F, et al. Biological effect of intranasally instilled titanium dioxide nanoparticles on female mice. NANO: Brief ReportsRev, 2008, 3: 279-285
[18]
27 Wang J X, Zhou G Q, Chen C Y, et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oraladministration. Toxicol Lett, 2007, 168: 176-185？？
33 Wang B, Feng W Y, Wang M, et al. Acute toxicological impact of nano- and submicro-scaled zinc oxide powder on healthy adult mice. JNanopart Res, 2008, 10: 263-276
39 Wang B, Wang Y, Feng W Y, et al. Trace metal disturbance in mice brain after intranasal exposure of nano- and submicron-sized Fe2O3 particles.Chem Anal (Warsaw, Pol), 2008, 53: 927-942
48 Lee K P, Trochimowicz H J, Reinhardt C F. Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years. ToxicolAppl Pharmacol, 1985, 79: 179-192
[29]
49 Heinrich U, Fuhst R, Rittinghausen S, et al. Chronic inhalation exposure of wistar rats and two different strains of mice to diesel engine exhaust,carbon black, and titanium dioxide. Inhalation Toxicol, 1995, 7: 533-556？？
[30]
50 Li X, Gilmour P S, Donaldson K, et al. Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.Brit Med J, 1996, 51: 1216-1222
[31]
51 Oberd.rster G, Gelein R, Johnston C J, et al. Ambient ultrafine particles: Inducers of acute lung injury? In: Dungworth D L, ed. RelationshipsBetween Respiratory Disease and Exposure to Air Pollution. Washington: ILSI Press, 1998. 216-229
[32]
52 Oberd.rster G, Ferin J, Lehnert B E. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect, 1994,102(Suppl 5): 173-179
[33]
54 Saito R, Dresselhaus G, Dresselhaus M S. Physical Properties of Carbon Nanotubes. London: Imperial College Press, 1998. 35-89
[34]
55 Jia G, Wang H F, Yan L, et al. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene. Environ SciTechnol, 2005, 39: 1378-1383？？
[35]
56 Liu B, Li X Y, Li B L, et al. Carbon nanotube based artificial water channel protein: Membrane perturbation and water transportation. Nano Lett,2009, 9: 1386-1394？？
[36]
57 Lam C W, James J T, Mccluskey R, et al. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation.Toxicol Sci, 2004, 77: 126-134
[37]
59 Deng X Y, Jia G, Wang H F, et al. Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon, 2007, 45: 1419-1424？？
2 Zhao Y L, Nalwa H S. Nanotoxicology—Interactions of Nanomaterials with Biological Systems. California: American Scientific Publishers, 2007-265-279
[40]
5 Johnston C J, Finkelstein J N, Mercer P, et al. Pulmonary effects induced by ultrafine ptfe particles. Toxicol Appl Pharmacol, 2000, 168: 208-215？？
[41]
9 Poland C A, Duffin R, Kinloch I, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilotstudy. Nat Nanotechnol, 2008, 3: 423-428？？
[42]
10 Kostarelos K. The long and short of carbon nanotube toxicity. Nat Biotechnol, 2008, 26: 774-776？？
[43]
16 Meng H, Chen Z, Xing G M, et al. Ultrahigh reactivity and grave nanotoxicity of copper nanoparticles. J Radioanal Nucl Chem, 2007, 272:595-598？？
[44]
24 Wang J X, Chen C Y, Liu Y, et al. Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystalphases. Toxicol Lett, 2008, 183: 72-80？？
[45]
25 Wang J X, Chen C Y, Yu H W, et al. Distribution of TiO2 particles in the olfactory bulb of mice after nasal inhalation using microbeam srxrfmapping techniques. J Radioanal Nucl Chem, 2007, 272: 527-531？？
[46]
26 Wang J X, Liu Y, Jiao F, et al. Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2nanoparticles. Toxicology, 2008, 254: 82-90？？
37 Wang B, Feng W Y, Wang M, et al. Transportation of intranasal instillation of fine Fe2O3 particles in brain: Micro-distribution, chemical states,and histopathological observation. Biol Trace Elem Res, 2007, 118: 233-243？？
[50]
38 Wang B, Feng W Y, Zhu M T, et al. Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxideparticles in mice. J Nanopart Res, 2009, 11: 41-53？？
[51]
40 Zhu M T, Feng W Y, Wang B, et al. Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Toxicology,2008, 247: 102-111？？
[52]
41 Zhu M T, Feng W Y, Wang Y, et al. Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in ratsand the potential health risk assessment. Toxicol Sci, 2009, 107: 342-351？？
46 Wang B, Feng W Y, Zhao Y L, et al. Status of study on biological and toxicological effects of nanoscale materials. Sci China Ser B-Chem, 2005,48: 385-394？？
[57]
47 Churg A, Stevens B, Wright J L. Comparison of the uptake of fine and ultrafine TiO2 in a tracheal explant system. Am J Physiol Lung Cell MolPhysiol, 1998, 274: 81-86
[58]
53 Oberd.rster G, Celein R M, Ferin J, et al. Association of particulate air pollution and acute mortality: Involvement of ultrafine particles?Inhalation Toxicol, 1995, 7: 111-124
[59]
58 Oberd.rster G. Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health, 2000, 74: 1-8？？
