1 Aitken R F, Hankin S M, Tran C L, et al. REFNANO: Reference Materials for Engineered Nanoparticle Toxicology and Metrology.Technical Report, Institute of Occupational Medicine, 2007
[2]
7 Repot of an OECD Workshop on Exposure Assessment and Exposure Mitigation: Manufactured Nanomaterials. Technical Report, OECDEnvironment, Health and Safety Publications, Series on the Safety of Manufactured Nanomaterials, No. 13, Organisation for EconomicCo-operation and Development, Paris. 2009
[3]
10 Ray S S, Maiti P, Okamoto M, et al. New polylactide/layered silicate nanocomposites. 1. Preparation, characterization, and properties.Macromolecules, 2002, 35: 3104-31103104
[4]
11 Wang K K, Koo C M, Chung I J. Physical properties of polyethylene/silicate nanocomposite blown films. J Appl Polym Sci, 2003, 89:2131-21362131??
[5]
12 Wan C, Qiao X, Zhang Y, et al. Effect of different clay treatment on morphology and mechanical properties of PVC-clay nanocomposites.Polym Test, 2003, 22: 453-461453??
[6]
15 Aaron L B. “Nano, nano” food packaging technology. Food Technol, 2003, 57: 52-5452
[7]
17 Margaret I, Sau L L, Vincent K M P, et al. Antimicrobial activities of silver dressings: An in vitro comparison. J Med Microbiol, 2006, 55:59-6359??
[8]
23 Tyan H L, Liu Y C, Wei K H. Thermally and mechanically enhanced clay/polyimide nanocomposite via reactive organoclay. Chem Mater,1999, 11: 1942-19471942??
[9]
25 Kotov N A, Magonov S, Tropsha E. Layer-by-layer self-assembly of alumosilicate—polyelectrolyte composites: Mechanism of deposition,crack resistance, and perspectives for novel membrane materials. Chem Mater, 1998, 10: 886-895886??
[10]
27 LaCoste A, Schaich K, Zumbrunnen D, et al. Advancing controlled release packaging through smart blending. Packag Technol Sci, 2005,18: 77-8777??
[11]
30 Jin-Hae C, Yeong Uk A, Donghwan C, et al. Poly(lactic acid) nanocomposites: Comparison of their properties with montmorillonite andsynthetic mica (II). Polymer, 2003, 44: 3715-37203715??
[12]
31 Chow W S, Lok S K. Thermal properties of poly(lactic acid)/organo—montmorillonite nanocomposites. J Therm Anal Calorim, 2009, 95:627-632627??
[13]
33 Avella M, De Vlieger J J, Errico M E, et al. Biodegradable starch/clay nanocomposite films for food packaging applications. Food Chem,2005, 93: 467-474467??
[14]
35 Nemmar A, Vanbilloen H, Hoylaerts M F, et al. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulationin hamster. Am J Respir Crit Care Med, 2001, 164: 1665-16681665
[15]
36 Kreyling W G, Semmler M, Erbe F, et al. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonaryorgans is size dependent but very low. J Toxicol Environ Health A, 2002, 65: 1513-15301513??
[16]
37 Maibach H I, Feldman R J, Milby T H, et al. Regional variation in percutaneous penetration in man. Pesticides. Arch Environ Health,1971, 23: 208-211208
[17]
38 Lademann J, Richter H, Otberg N, et al. Application of a dermatological laser scanning confocal microscope for investigation in skinphysiology. J Laser Phys, 2003, 13: 756-760756
[18]
40 Alvarez-Roman R, Naik A, Kalia Y N, et al. Skin penetration and distribution of polymeric nanoparticles. J Control Release, 2004, 99:53-6253??
[19]
44 Hillyer J F, Albrecht R M. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J PharmSci, 2001, 90: 1927-19361927
[20]
49 Donaldson K, Lang T C. Inflammation caused by particles and fibers. Inhal Toxicol, 2002, 14: 5-275??
[21]
50 Halliwell B, Gutteridge J M C. Free Radicals in Biology and Medicine. Oxford: Oxford University Press, 1999
[22]
51 Li N, Sioutas C, Cho A, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Persp,2003, 111: 455-460455??
[23]
52 Yamakoshi Y, Umezawa N, Ryu A, et al. Active oxygen species generated from photoexcited fullerene (C60) as potential medicines:O2?· versus 1O2. J Am Chem Soc, 2003, 125: 12803-1280912803??
[24]
53 Kedar N P. Can we prevent Parkinson’s and Alzheimer’s disease? J Postgrad Med, 2003, 49: 236-245236
[25]
56 Stone V, Johnson G D, Wilton J C, et al. Effect of oxidative stress and disruption of Ca2+ homeostasis on hepatocyte canalicular functionin vitro. Biochem Pharmacol, 1994, 47: 625-632625??
[26]
57 Matthew J. Campen J D, McDonald, et al. Cardiovascular effects of inhaled diesel exhaust in spontaneously hypertensive rats. CardiovascToxicol, 2003, 3: 353-361353
[27]
60 Lomer M C, Thompson R P, Powell J J. Fine and ultrafine particles of the diet: Influence on the mucosal immune response and associationwith Crohn’s disease. Proc Nutr Soc, 2002, 61: 123-130123
[28]
61 Lomer M C, Grainger S L, Ede R, et al. Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with activeCrohn’s disease. Eur J Gastroen Hepat, 2005, 17: 377-384377??
[29]
63 Gurr J R, Wang A S, Chen C H, et al. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damageto human bronchial epithelial cells. Toxicology, 2005, 213: 66-7366??
[30]
64 Landsiedel R, Kapp M D, Schulz M, et al. Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of testmaterial, potential artifacts and limitations—many questions, some answers. Mutat Res, 2009, 681: 241-258241??
[31]
65 Mroz R M, Schins R P, Li H, et al. Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways. Eur Respir J,2008, 31: 241-251241??
[32]
66 Rahman Q, Lohani M, Dopp E, et al. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in syrian hamster embryofibroblasts. Environ Health Persp, 2002, 110: 797-800797??
[33]
67 Papageorgiou I, Brown C, Schins R, et al. The effect of nano- and micron-sized particles of cobalt—chromium alloy on human fibroblastsin vitro. Biomaterials, 2007, 28: 2946-29582946??
[34]
68 Alexander B M, Jeffrey W G. Characterization of polymer-layered silicate (clay) nanocomposites by transmission electron microscopy andX-ray diffraction: A comparative study. J App Polym Sci, 2003, 87: 1329-13381329??
[35]
69 Vermogen A, Masenelli-Varlot K, Seguela R, et al. Evaluation of the structure and dispersion in polymer-layered silicate nanocomposites.Macromolecules, 2005, 38: 9661-96699661??
[36]
70 Usuki A, Hasegawa N, Kadoura H, et al. Three dimensional observation of structure and morphology in nylon-6/clay nanocomposite.Nano Lett, 2001, 1: 271-272271??
[37]
71 Perrin-Sarazin F, Ton-That M T, Bureau M N, et al. Micro- and nano-structure in polypropylene/clay nanocomposites. Polymer, 2005, 46:11624-1163411624??
[38]
73 Vaia R A, Liu W. X-ray powder diffraction of polymer/layered silicate nanocomposites: Model and practice. J Polym Sci B: Polym Phys,2002, 40: 1590-16001590??
[39]
74 Bafna A, Beaucage G, Mirabella F, et al. 3D hierarchical orientation in polymer-clay nanocomposite films. Polymer, 2003, 44: 1103-11151103??
[40]
78 Jeschke G, Panek G, Schleidt S, et al. Addressing the interface in polymer-clay nanocomposites by electron paramagnetic resonance spectroscopyon surfactant probes. Polym Eng Sci, 2004, 44: 1112-11211112??
[41]
80 Maupin P H, Gilman J W, Harris R H, et al. Optical probes for monitoring intercalation and exfoliation in melt-processed polymer nanocomposites.Macromol Rapid Commun, 2004, 25: 788?792??
[42]
2 Bouwmeester H, Dekkers S, Noordam M, et al. Health Impact of Nanotechnologies in Food Production. Technical Report, RIKILT—Institute of Food Safety, Wageningen University and Research Centre, 2007
[43]
3 Torchilin V P. Targeted pharmaceutical nanocarriers for cancer therapy and imaging. AAPS J, 2007, 9: E128-E147??
[44]
4 Carmen I, Moraru C P, Panchapakesan, et al. Nanotechnology: A new frontier in food science. Food Technol, 2003, 57: 24-2924
[45]
5 Alexandra M, Dubois P. Polymer-layered silicate nanocomposites: Preparation, properties and uses of a new class of materials. Mat SciEng R, 2000, 28: 1-631??
[46]
6 Peter ?, Qasim C, Du?an B. Migration of engineered nanoparticles from polymer packaging to food—A physicochemical view. J FoodNutr Res, 2008, 47:105-113105
[47]
8 Nanomaterials in REACH. Technical Report, Follow-up to the 6th Meeting of the REACH Competent Authorities for the implementationof Regulation (EC) 1907/2006 (REACH), Brussels. 2008
[48]
9 Kotsilkova R, Petkova V, Pelovski Y. Thermal analysis of polymer-silicate nanocomposites. J Therm Anal Calorim, 2001, 64: 591-598591??
[49]
13 Schartel B, P?tschke P, Knoll U, et al. Fire behaviour of polyamide 6/multiwall carbon nanotube nanocomposites. Eur Polym J, 2005, 41:1061-10701061??
[50]
14 Xu B, Zheng Q, Song Y, et al. Calculating barrier properties of polymer/clay nanocomposites: Effects of clay layers. Polymer, 2006, 47:2904-29102904??
[51]
16 Jun S K, Eunye K, Kyeong N Y, et al. Antimicrobial effects of silver nanoparticles. Nanomed-Nanotechnol, 2007, 3: 95-10195??
[52]
18 Mohammed F A, Balaji K, Girilal M, et al. Mycobased synthesis of silver nanoparticles and their incorporation into sodium alginate filmsfor vegetable and fruit preservation. J Agric Food Chem, 2009, 57: 6246-62526246??
[53]
19 Ke Z, Yongping B. Improve the gas barrier property of PET film with montmorillonite by in situ interlayer polymerization. Mater Lett,2005, 59: 3348-33513348??
[54]
20 Kostas S T, Peter C L, In P, et al. Epoxy—clay fabric film composites with unprecedented oxygen-barrier properties. Chem Mater, 2006,18: 4393-43984393??
[55]
21 Park S Y, Cho Y H, Richard A V. Three-dimensional structure of the zone-drawn film of the nylon-6/layered silicate nanocomposites.Macromolecules, 2005, 38: 1729-17351729??
[56]
22 Yeh J M, Liou S J, Lai C Y, et al. Enhancement of corrosion protection effect in polyaniline via the formation of polyaniline—clay nanocompositematerials. Chem Mater, 2001, 13: 1131-11361131??
[57]
24 Ratchana L, Steven S, Peter F G. Stability of diblock copolymer/layered silicate nanocomposite thin films. Macromolecules, 2000, 33:5227-52345227??
[58]
26 del N M, Cannarsi M, Altieri C, et al. Effect of Ag-containing nano—composite active packaging system on survival of alicyclobacillusacidoterrestris. J Food Sci, 2004, 69: E379?E383??
[59]
28 Lopez-Rubio A, Gavara R, Lagaron J. Bioactive packaging: Turning foods into healthier foods through biomaterials. Trends Food SciTechnol, 2006, 17: 567-575567??
[60]
29 Nachay K. Analyzing nanotechnology. Food Technol, 2007, 61: 34-3634
[61]
32 McGlashan S A, Halley P J. Preparation and characterisation of biodegradable starch-based nanocomposite materials. Polym Int, 2003, 52:1767-17731767??
[62]
34 Paul J A B, David R, Stephan H, et al. The potential risks of nanomaterials: A review carried out for ECETOC. Part Fibre Toxicol, 2006,3: 1-351??
[63]
39 Pflücker F, Wendel V, Hohenberg H, et al. The human stratum corneum layer: An effective barrier against dermal uptake of differentforms of topically applied micronised titanium dioxide. Skin Pharmacol Appl Skin Physiol, 2001, 14(Suppl 1): 92-9792
[64]
41 Hoet P H, Bruske-Hohlfeld I, Salata O V. Nanoparticles—known and unknown health risks. J Nanobiotechnology, 2004, 2: 12—27??
[65]
42 des R A, Fievez V, Garinot M, et al. Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. JControl Release, 2006, 116: 1-271??
[66]
43 Szentkuti L. Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in thepre-epithelial mucus gel layer of the rat distal colon. J Control Release, 1997, 46: 233-242233??
[67]
45 Jani P, Halbert G W, Langridge J, et al. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency.J Pharm Pharmacol, 1990, 42: 821-826821
[68]
46 Samuel K, Lai D, O’Hanlon E, et al. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Nat Acad SciUSA, 2007, 104: 1482-14871482??
[69]
47 Kim Y S, Kim J S, Cho H S, et al. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticlesin Sprague-Dawley rats. Inhal Toxicol, 2008, 20: 575-583575??
[70]
48 Günter O, Eva O, Jan O. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Persp, 2005,113: 823-839823??
[71]
54 Calderón-Garcidue?as L, Reed W, Maronpot R R, et al. Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severeair pollution. Toxicol Pathol, 2004, 32: 650-658650??
[72]
55 Brown D M, Donaldson K, Borm P J, et al. Calcium and ROS-mediated activation of transcriptionfactors and TNF-alpha cytokine geneexpression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol, 2004, 286: L344?L353??
[73]
58 Suwa T, Hogg J C, Quinlan K B, et al. Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol, 2002, 39:935-942935??
[74]
59 Andrej K, Andreas S, Shinji T, et al. Ultrafine particles exert prothrombotic but not inflammatory effects on the hepatic microcirculationin healthy mice in-vivo. Circulation, 2004, 109: 1320-13251320??
[75]
62 Powell J J, Harvey R S, Ashwood P, et al. Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatorybowel disease. J Autoimmun, 2000, 14: 99-10599??
[76]
72 Yalcin B, Cakmak M. The role of plasticizer on the exfoliation and dispersion and fracture behavior of clay particles in PVC matrix: Acomprehensive morphological study. Polymer, 2004, 45: 6623-66386623??
[77]
75 Vaia R A, Liu W, Koerner H. Analysis of small-angle scattering of suspensions of organically modified montmorillonite: Implications tophase behavior of polymer nanocomposites. J Polym Sci B: Polym Phys 2003, 41: 3214-32363214
[78]
76 VanderHart D L, Asano A, Gilman J W. Solid-state NMR investigation of paramagnetic nylon-6 clay nanocomposites. 1. Crystallinity,morphology, and the direct influence of Fe3+ on nuclear spins. Chem Mater, 2001, 13: 3781?3795.
[79]
77 VanderHart D L, Asano A, Gilman J W. Solid-state NMR investigation of paramagnetic nylon-6 clay nanocomposites. 2. Measurement ofclay dispersion, crystal stratification, and stability of organic modifiers. Chem Mater, 2001, 13: 3796-38093796
[80]
79 Loo L S, Gleason K K. Fourier transform infrared investigation of the deformation behavior of montmorillonite in nylon-6/nanoclaynanocomposite. Macromolecules, 2003, 36: 2587-25902587??