8 Lewin M, Carlesso N, Tung C H, et al. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitorcells. Nat Biotechnol, 2000, 18: 410-414？？
10 ISO 10993-1: 1992. Biological evaluation of medical devices—Part 1: Evaluation and testing
[6]
11 Holgate S T. Exposure, uptake, distribution and toxicity of nanomaterials in humans. J Biomed Nanotechnol, 2010, 6: 1-19？？
[7]
12 Jain T K, Richey J, Strand I, et al. Magnetic nanoparticles with dual functional properties drug delivery and magnetic resonance imaging.Biomaterials, 2008, 29: 4012-4021？？
[8]
20 Barrett D G, Yousaf M N. Design and applications of biodegradable polyester tissue scaffolds based on endogenous monomers found inhuman metabolism. Molecules, 2009, 14: 4022-4050？？
[9]
22 Prijic S, Scancar J, Romih R, et al. Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignantcells by an external magnetic field. J Membr Biol, 2010, 236: 167-179？？
[10]
23 Kekkonen V, Lafreniere N, Ebara M. Synthesis and characterization of biocompatible magnetic glyconanoparticles. J Magn Magn Mater,2009, 321: 1393-1396？？
[11]
25 Mahmoudi M, Shokrgozar M A, Simchi A, et al. Multiphysics flow modeling and in vitro toxicity of iron oxide nanoparticles coated withpoly (vinyl alcohol). J Phys Chem C, 2009, 113: 2322-2331？？
[12]
26 Mahmoudi M, Simchi A, Imani M, et al. A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxidenanoparticles. Colloids Surf B, 2010, 75: 300-309？？
[13]
27 Arbab A S, Bashaw L A, Miller B R, et al. Characterization of biophysical and metabolic properties of cells labeled withsuperparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging. Rdiology, 2003, 229: 838-846
[14]
28 Arbab A S, Wilson L B, Ashari B, et al. A model of lysosomal metabolism of dextran coated superpara-magnetic iron oxide (SPIO)nanoparticles: Implications for cellular magnetic resonance imaging. NMR Biomed, 2005, 18: 383-389？？
[15]
29 Nel A, Xia T, Madler L, et al. Toxic potential of materials at the nanolevel. Science, 2006, 311: 622-627？？
[16]
30 Hou C H, Chen C W, Hou S M, et al. The fabrication and characterization of dicalcium phosphate dihydrate-modified magneticnanoparticles and their performance in hyperthermia processes in vitro. Biomaterials, 2009, 30: 4700-4707？？
[17]
34 Chen H Y, Hsiao J K, Wang J L, et al. Immunological impact of magnetic nanoparticles (Ferucarbotran) on murine peritonealmacrophages. J Nanopart Res, 2010, 12: 151-160？？
[18]
35 Pfaller T, Renato C, Inge N, et al. The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis ofnanoparticle-induced events. Nanotoxicology, 2010, 4: 52-72？？
37 Springer T A. Adhesion receptors of the immune system. Nature, 1990, 346: 425-434？？
[21]
38 Risinger G M Jr, Hunt T S, Updike D L, et al. Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by bothstimulatory and inhibitory signals in response to growth factors. J Biol Chem, 2006, 281: 25915-25925？？
[22]
41 Nel A E, Madler L, Velegol D, et al. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater, 2009, 8:543-557？？
[23]
43 Sun C, Du K, Fang C, et al. PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: Theirphysicochemical properties and function in vivo. ACS Nano, 2010, 4: 2402-2410？？
[24]
1 Widder K J, Senyei A E, Ranney D F. In vitro release of biologically active adriamycin by magnetically responsive albumin microspheres.Cancer Res, 1980, 40: 3512-3517
[25]
3 Harisinghani M G, Barentsz J, Hahn P F, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. NEngl J Med, 2003, 348: 2491-2499？？
15 Sadeghiani N, Barbosa L S, Silva L P. Genotoxicity and inflammatory investigation in mice treated with magnetite nanoparticles surfacecoated with polyaspartic acid. J Magn Magn Mater, 2005, 289: 466-468？？
[32]
16 Chou L S, Firth J D, Uitto V J, et al. Substratum surface topography alters cell shape and regulates fibroectin mRNA level, mRNAstability, secretion and assembly in human fibroblasis. J Cell Sci, 1995, 108: 1563-1573
[33]
17 Shi X, Wang Y, Varshney R R, et al. In-vitro osteogenesis of synovium stem cells induced by controlled release of bisphosphate additivesfrom microspherical mesoporous silica composite. Biomaterials, 2009, 30: 3996-4005？？
[34]
18 Denise N, Johnson L, Kimberly P, et al. Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagicvacuole accumulation, and mitochondrial dysfunction. Toxicol Appl Pharmacol, 2010, 248: 249-258？？
[35]
19 Dilnawaz F, Singh A, Mohanty C, et al. Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy.Biomaterials, 2010, 31: 3694-3706？？
[36]
21 Brunner T J, Wick P, Manser P, et al. In vitro cytotoxicity of oxide nanoparticles: Comparison to asbestos, silica, and the effect of particlesolubility. Environ Sci Technol, 2006, 40: 4374-4381？？
[37]
24 Aqil A, Vasseur S, Duguet E, et al. PEO coated magnetic nanoparticles for biomedical application. Eur Polym J, 2008, 44: 3191-3199？？
[38]
31 Díaz B, Sánchez-Espinel C, Arruebo M, et al. Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles andnanoparticle aggregates. Small, 2008, 11: 2025-2034
[39]
32 Chen A Z, Kang Y Q, Pu X M, et al. Development of Fe3O4-poly(L-lactide) magnetic microparticles in supercritical CO2. J ColloidInterface Sci, 2009, 330: 317-322
[40]
33 Chou L S, Firth J D, Nathanson D, et al. Effect of titanium on transcriptional and post-transcriptional regulation of fibronectin in huamnfibroblasts. J Biomed Mater Res, 1996, 31: 209-217？？
[41]
39 Chen Y C, Hsiao J K, Liu H M, et al. The inhibitory effect of superparamagnetic iron oxide nanoparticle (Ferucarbotran) on osteogenicdifferentiation and its signaling mechanism in human mesenchymal stem cells. Toxicol Appl Pharmacol, 2010, 245: 272-279？？
[42]
40 Huang D M, Hsiao J K, Chen Y C, et al. The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxidenanoparticles. Biomaterials, 2009, 30: 3645-3651？？
[43]
42 Park E J, Kim H, Kim Y, et al. Inflammatory responses may be induced by a single intratracheal instillation of iron nanoparticles in mice.Toxicology, 2010, 275: 65-71？？
[44]
44 Wang S B, Xu F H, He H S, et al. Novel alginate-poly(L-Histidine) microcapsules as drug carriers: In vitro protein release and short-termstability. Macromol Biosci, 2005, 5: 408-414？？
[45]
45 Chen A Z, Li Y, Chau F T, et al. Microencapsulation of puerarin nanoparticles by poly(L-lactide) in a supercritical CO2 process. ActaBiomater, 2009, 5: 2913-2919
[46]
46 Chen A Z, Li Y, Chen D, et al. Development of core-shell microcapsules by a novel supercritical CO2 process. J Mater Sci Mater Med,2009, 20: 751-758？？
[47]
47 Chen A Z, Li Y, Chau F T, et al. Application of organic nonsolvent in the process of solution-enhanced dispersion by supercritical CO2 toprepare puerarin fine particles. J Supercrit Fluids, 2009, 49: 394-402？？
