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科学通报  2011 

小G蛋白Ran在细胞周期调控中的作用

DOI: 10.1360/972011-1206, PP. 2472-2477

Keywords: Ran,细胞周期,核质运输,纺锤体组装,生长素,Ran,结合蛋白

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Abstract:

Ran(Ras-RelatedNuclearProtein)作为小G蛋白家族的一类,具有GTP水解酶的功能,在细胞内行使“分子开关”的作用.利用酵母和脊椎动物细胞的研究结果表明,Ran参与细胞间期的核质运输、细胞分裂前期的纺锤体组装和细胞分裂末期的核膜重建等过程.虽然在高等植物细胞中,关于Ran功能的研究报道还十分有限,但是近来利用不同模式植物的研究结果表明,在多种植物细胞中,Ran都参与了与细胞周期进程相关过程的调节.此外,也有研究表明Ran还影响生长素信号通路.因此,Ran蛋白在动物及植物等不同物种之间的功能具有一定保守性和特异性.

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