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科学通报  2011 

夹脊电针疗法对脊髓横断损伤大鼠的作用

, PP. 2765-2771

Keywords: 夹脊电针,脊髓横断,大鼠,内源性神经干细胞

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Abstract:

在雌性Wistar成年大鼠胸髓第10节段造成脊髓横断损伤,然后在脊髓损伤区给予夹脊电针治疗,为脊髓组织在电场的作用下再生提供一个良好的微环境.脊髓横断术后7和14d,通过对大鼠运动功能的观察发现,夹脊电针治疗可以促进神经的恢复;脊髓损伤区的Brdu,Nestin,GFAP阳性神经元计数、NestinmRNA及GFAPmRNA相对表达量的变化也证实,夹脊电针治疗可以促进脊髓损伤后的神经干细胞增殖,从而发挥神经元及其他功能细胞的修复作用.电生理学检测结果表明,夹脊电针治疗可以提高脊髓传导速度.研究结果显示,夹脊电针和夹脊电针预处理治疗方法对于脊髓损伤后神经干细胞增殖及神经功能的恢复具有重要作用,为临床应用提供了新的思路.

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