3 Roy-Burman A, Savel R H, Racine S, et al. Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis, 2001, 183: 1767-1774？？
[2]
6 Diggle S P, Cornelis P, Williams P, et al. 4-quinolone signalling in Pseudomonas aeruginosa: Old molecules, new perspectives. Int J Med Microbiol, 2006, 296: 83-91？？
[3]
8 Diggle S P, Matthijs S, Wright V J, et al. The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem Biol, 2007, 14: 87-96？？
[4]
9 Schuster M, Lostroh C P, Ogi T, et al. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes:A transcriptome analysis. J Bacteriol, 2003, 185: 2066-2079？？
[5]
10 Wagner V E, Bushnell D, Passador L, et al. Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: Effects of growth phase and environment. J Bacteriol, 2003, 185: 2080-2095？？
[6]
11 Diggle S P, Winzer K, Chhabra S R, et al. The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol Microbiol, 2003, 50: 29-43？？
[7]
16 Frank D W, Iglewski B H. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. J Bacteriol, 1991, 173: 6460-6468
[8]
17 Zheng Z, Chen G, Joshi S, et al. Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system. J Biol Chem, 2007, 282: 6136-6142
[9]
19 Liang H, Li L, Dong Z, et al. The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J Bacteriol, 2008, 190: 6217-6227？？
[10]
20 Simon R, Priefer U, Pühler A. A broad host range mobilization system for in vivo genetic engineering: Transposon mutagenesis in gram negative bacteria. Bio/Technology, 1983, 1: 784-791？？
[11]
21 Hoang T T, Karkhoff-Schweizer R R, Kutchma A J, et al. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: Application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene, 1998, 212: 77-86？？
[12]
22 Schweizer H P. Two plasmids, X1918 and Z1918, for easy recovery of the xylE and lacZ reporter genes. Gene, 1993, 134: 89-91
[13]
24 Duan K, Dammel C, Stein J, et al. Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication. Mol Microbiol, 2003, 50: 1477-1491？？
[14]
25 Bleves S, Soscia C, Nogueira-Orlandi P, et al. Quorum sensing negatively controls type III secretion regulon expression in Pseudomonas aeruginosa PAO1. J Bacteriol, 2005, 187: 3898-3902？？
[15]
1 Bodey G P, Bolivar R, Fainstein V, et al. Infections caused by Pseudomonas aeruginosa. Rev Infect Dis, 1983, 5: 279-313？？
[16]
2 Smith R S, Iglewski B H. P. aeruginosa quorum-sensing systems and virulence. Curr Opin Microbiol, 2003, 6: 56-60？？
[17]
4 Williams P, Winzer K, Chan W C, et al. Look who’s talking: Communication and quorum sensing in the bacterial world. Phil Trans R Soc Lond B Biol Sci, 2007, 362: 1119-1134？？
[18]
5 Miller M B, Bassler B L. Quorum sensing in bacteria. Annu Rev Microbiol, 2001, 55: 165-199？？
[19]
7 von Bodman S B, Willey J M, Diggle S P. Cell-cell communication in bacteria: United we stand. J Bacteriol, 2008, 190: 4377-4391？？
[20]
12 Cao H, Krishnan G, Goumnerov B, et al. A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proc Natl Acad Sci USA, 2001, 98: 14613-14618？？
[21]
13 Wade D S, Calfee M W, Rocha E R, et al. Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. J Bacteriol, 2005, 187: 4372-4380？？
[22]
14 Frank D W. The exoenzyme S regulon of Pseudomonas aeruginosa. Mol Microbiol, 1997, 26: 621-629？？
[23]
15 Vallis A J, Yahr T L, Barbieri J T, et al. Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions. Infect Immun, 1999, 67: 914-920
[24]
18 Rietsch A, Vallet-Gely I, Dove S L, et al. ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proc Natl Acad Sci USA, 2005, 102: 8006-8011？？
[25]
23 Ditta G, Stanfield S, Corbin D, et al. Broad host range DNA cloning system for gram-negative bacteria: Construction of a gene bank of Rhizobium meliloti. Proc Natl Acad Sci USA, 1980, 77: 7347-7351？？
[26]
26 McGrath S, Wade D S, Pesci E C. Dueling quorum sensing systems in Pseudomonas aeruginosa control the production of the Pseudomonas quinolone signal (PQS). FEMS Microbiol Lett, 2004, 230: 27-34？？
