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科学通报  2015 

转移消失蛋白研究进展

DOI: 10.1360/N972014-00981, PP. 356-366

Keywords: 转移消失蛋白,细胞膜,肿瘤,神经系统,B细胞,肾脏功能,信号传导,靶向药物

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Abstract:

转移消失蛋白(missinginmetastasis,MIM)是一种重要的胞内膜调控蛋白,属于inverseBAR(I-BAR)家族成员,能结合细胞膜并在细胞极化、运动和内吞作用等过程中发挥调节功能,其表达异常与多种疾病尤其是肿瘤发生或转移相关,在神经系统、循环系统和生殖泌尿系统中也有一定作用.MIM蛋白的生物学功能包括调节肌动蛋白细胞骨架、与皮动蛋白等其他蛋白相互作用、参与细胞信号通路调控、改变细胞膜形态并促进细胞极化等,在结构上表现出典型I-BAR家族成员特征,借助其N端的I-BAR区域自聚合形成二聚体,促使细胞膜形成伪足状突起,甚至可以调控人造磷脂囊泡,但二聚体的形成也可被靶向的多肽等抑制剂阻断.除作用于蛋白I-BAR,RPTP结合域的特异性多肽外,MIM也可被RNAi干涉,在肿瘤生物治疗领域具有开发潜力.本文回顾了MIM蛋白相关医学研究进展,综述了MIM蛋白已知的生物功能,分析了MIM蛋白靶向治疗及其他应用前景,并提出了可能的研究新方向、新思路.

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