1 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington: American Psychiatric Publishing, 2013
[2]
2 Baron-Cohen S, Scott F J, Allison C, et al. Prevalence of autism-spectrum conditions: UK school-based population study. Br J Psychiatry, 2009, 194: 500-509
[3]
3 Kim Y S, Leventhal B L, Koh Y J, et al. Prevalence of autism spectrum disorders in a total population sample. Am J Psychiatry, 2011, 168: 904-912
[4]
4 Blumberg S J, Bramlett M D, Kogan M D, et al. Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011-2012. Natl Health Stat Report, 2013, 65: 1-11
[5]
5 Guo H, Hu Z M, Xia K. Progress of the genetic etiology of autism spectrum disorders and the proposed genotype and phenotype correlation project (in Chinese). Chin Bull Life Sci, 2014, 26: 571-582 [郭辉, 胡正茂, 夏昆. 孤独症的遗传病因学研究进展及基因型-表型关联研究计划. 生命科学, 2014, 26: 571-
[6]
6 Harvard School of Public Health (HSPH). Autism has high costs to U.S. society. HSPH, 2006, http://archive.sph.harvard.edu/press-releases/2006-releases/press04252006.html
[7]
7 Rutter M. Aetiology of autism: Findings and questions. J Intellect Disabil Res, 2005, 49: 231-238
[8]
8 Huguet G, Ey E, Bourgeron T. The genetic landscapes of autism spectrum disorders. Annu Rev Genomics Hum Genet, 2013, 14: 191-213
[9]
9 Ledford J R, Gast D L. Feeding problems in children with autism spectrum disorders: A review. Focus Autism Other Dev Stud, 2006, 21: 153-166
[10]
10 Sharp W G, Jaquess D L, Lukens C T. Multi-method assessment of feeding problems among children with autism spectrum disorders. Res Autism Spectr Disord, 2013, 7: 56-65
[11]
11 Zimmer M, Hart L, Manning Courtney P, et al. Food variety as a predictor of nutritional status among children with autism. J Autism Dev Disord, 2012, 42: 549-556
[12]
12 Hediger M, England L, Molloy C, et al. Reduced bone cortical thickness in boys with autism or autism spectrum disorder. J Autism Dev Disord, 2008, 38: 848-856
[13]
13 Bandini L G, Anderson S E, Curtin C, et al. Food selectivity in children with autism spectrum disorders and typically developing children. J Pediatr, 2010, 157: 259-264
[14]
14 Krajmalnik-Brown R, Lozupone C, Kang D W, et al. Gut bacteria in children with autism spectrum disorders: Challenges and promise of studying how a complex community influences a complex disease. Microb Ecol Health Dis, 2015, 26: 26914
[15]
15 Gugusheff J R, Ong Z Y, Muhlhausler B S. The early origins of food preferences: Targeting the critical windows of development. FASEB J, 2014, 29: 365-373
[16]
16 Gardener H, Spiegelman D, Buka S L. Perinatal and neonatal risk factors for autism: A comprehensive meta-analysis. Pediatrics, 2011, 128: 344-355
[17]
17 Ong Z Y, Muhlhausler B S. Maternal “junk-food” feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring. FASEB J, 2011, 25: 2167-2179
[18]
18 Surén P, Roth C, Bresnahan M, et al. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA, 2013, 309: 570-577
[19]
19 James S J, Melnyk S, Fuchs G, et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr, 2009, 89: 425-430
[20]
20 Bohannon J. The theory? Diet causes violence. The Lab? Prison. Science, 2009, 325: 1614-1616
[21]
21 Bjorklund G. The role of zinc and copper in autism spectrum disorders. Acta Neurobiol Exp, 2013, 73: 225-236
[22]
22 Vela G, Stark P, Socha M, et al. Zinc in gut-brain interaction in autism and neurological disorders. Neural Plas, 2015, 2015: 972791
[23]
23 Yang Y F. Nutritional metabonomics application in pediatric child care (in Chinese). Chin J Child Care, 2015, 23: 225-237 [杨玉凤. 营养代谢组学在儿科儿童保健中的应用. 中国儿童保健杂志, 2015, 23: 225-
[24]
24 Adams J, Johansen L, Powell L, et al. Gastrointestinal flora and gastrointestinal status in children with autism—comparisons to typical children and correlation with autism severity. BMC Gastroenterol, 2011, 11: 22
[25]
25 Adams J B, Holloway C. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med, 2004, 10: 1033-1039
[26]
26 Adams J, Audhya T, McDonough Means S, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab, 2011, 8: 1
[27]
27 Adams J, Audhya T, McDonough Means S, et al. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr, 2011, 11: 1-30
[28]
28 Lelord G, Muh J P, Barthelemy C, et al. Effects of pyridoxine and magnesium on autistic symptoms—initial observations. J Autism Dev Disord, 1981, 11: 219-230
[29]
29 Bertoglio K, James S J, Deprey L, et al. Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism. J Altern Complement Med, 2010, 16: 555-560
[30]
30 Hallahan B, Garland M R. Essential fatty acids and mental health. Br J Psychiatry, 2005, 186: 275-277
[31]
31 Kidd P M. Omega-3 DHA and EPA for cognition, behavior, and mood: Clinical findings and structural-functional synergies with cell membrane phospholipids. Altern Med Rev, 2007, 12: 207-227
[32]
32 Logan A C. Omega-3 fatty acids and major depression: A primer for the mental health professional. Lipids Health Dis, 2004, 3: 25
[33]
33 James S, Montgomery P, Williams K. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD). Cochrane Database Syst Rev, 2011, 11: CD007992
[34]
34 Mostafa G, Al-Ayadhi L. Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: Relation to gastrointestinal manifestations. Behav Brain Funct, 2015, 11: 1-7
[35]
35 Amminger G P, Berger G E, Sch？fer M R, et al. Omega-3 fatty acids supplementation in children with autism: A double-blind randomized, placebo-controlled pilot study. Biol Psychiatry, 2007, 61: 551-553
[36]
36 Bent S, Bertoglio K, Ashwood P, et al. A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. J Autism Dev Disord, 2011, 41: 545-554
[37]
37 Mankad D, Dupuis A, Smile S, et al. A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism. Mol Autism, 2015, 6: 1-11
[38]
88 El-Ansary A, Al-Ayadhi L. Neuroinflammation in autism spectrum disorders. J Neuroinflammation, 2012, 9: 265
[39]
89 Enstrom A, Krakowiak P, Onore C, et al. Increased IgG4 levels in children with autism disorder. Brain Behav Immun, 2009, 23: 389-395
[40]
90 McLean M H, Dieguez D, Miller L M, et al. Does the microbiota play a role in the pathogenesis of autoimmune diseases? Gut, 2014, 64: 332-341
[41]
91 Ling Z, Li Z, Liu X, et al. Altered fecal microbiota composition associated with food allergy in infants. Appl Environ Microbiol, 2014, 80: 2546-2554
[42]
92 Cénit M C, Matzaraki V, Tigchelaar E F, et al. Rapidly expanding knowledge on the role of the gut microbiome in health and disease. Biochim Biophys Acta, 2014, 1842: 1981-1992
[43]
93 Becker K G. Autism, asthma, inflammation, and the hygiene hypothesis. Med Hypotheses, 2007, 69: 731-740
[44]
94 McCann D, Barrett A, Cooper A, et al. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: A randomised, double-blinded, placebo-controlled trial. Lancet, 2007, 370: 1560-1567
[45]
95 Dufault R, Lukiw W, Crider R, et al. A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States. Clin Epigenetics, 2012, 4: 6
[46]
96 Chassaing B, Koren O, Goodrich J K, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature, 2015, 519: 92-96
[47]
97 James S J, Cutler P, Melnyk S, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr, 2004, 80: 1611-1617
[48]
98 James S J, Melnyk S, Jernigan S, et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet, 2006, 141B: 947-956
[49]
99 Roberts E M, English P B, Grether J K, et al. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the california central valley. Environ Health Perspect, 2007, 115: 1482-1489
[50]
100 Yassa H A. Autism: A form of lead and mercury toxicity. Environ Health Perspect, 2014, 38: 1016-1024
[51]
101 Adams J, Audhya T, McDonough-Means S, et al. Toxicological status of children with autism vs. neurotypical children and the association with autism severity. Biol Trace Elem Res, 2013, 151: 171-180
[52]
102 Rutter M. Incidence of autism spectrum disorders: Changes over time and their meaning. Acta P？diatrica, 2005, 94: 2-15
[53]
103 Garrecht M, Austin D W. The plausibility of a role for mercury in the etiology of autism: A cellular perspective. Toxicol Environ Chem, 2011, 93: 1251-1273
[54]
147 Williams B L, Hornig M, Parekh T, et al. Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio, 2012, 3: e00261
[55]
148 Benach J L, Li E, McGovern M M. A microbial association with autism. MBio, 2012, 3: pii:e00019-12
[56]
149 Akins R S, Angkustsiri K, Hansen R. Complementary and alternative medicine in autism: An evidence-based approach to negotiating safe and efficacious interventions with families. Neurotherapeutics, 2010, 7: 307-319
[57]
150 McCormick D A. GABA as an inhibitory neurotransmitter in human cerebral cortex. J Neurophysiol, 1989, 62: 1018-1027
[58]
151 Komura J, Tamai I, Senmaru M, et al. Brain-to-blood active transport of b-alanine across the blood-brain barrier. FEBS Lett, 1997, 400: 131-135
[59]
152 Ishiwari K, Mingote S, Correa M, et al. The GABA uptake inhibitor b-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis. J Neurosci Methods, 2004, 140: 39-46
[60]
153 Aldred S, Moore K, Fitzgerald M, et al. Plasma amino acid levels in children with autism and their families. J Autism Dev Disord, 2003, 33: 93-97
[61]
154 Burrus C J. A biochemical rationale for the interaction between gastrointestinal yeast and autism. Med Hypotheses, 2012, 79: 784-785
[62]
155 Ka？u？na Czaplińska J, B？aszczyk S. The level of arabinitol in autistic children after probiotic therapy. Nutrition, 2012, 28: 124-126
[63]
156 Finegold S M, Dowd S E, Gontcharova V, et al. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe, 2010, 16: 444-453
[64]
157 Angelis M D, Piccolo M, Vannini L, et al. Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS One, 2013, 8: e76993
[65]
158 Wang L, Christophersen C T, Sorich M J, et al. Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder. Mol Psychiatry, 2013, 4: 42
[66]
159 Gondalia S V, Palombo E A, Knowles S R, et al. Molecular characterisation of gastrointestinal microbiota of children with autism (with and without gastrointestinal dysfunction) and their neurotypical Siblings. Autism Res, 2012, 5: 419-427
[67]
160 Hsiao E Y, McBride S W, Hsien S, et al. The microbiota modulates gut physiology and behavioral abnormalities associated with autism. Cell, 2013, 155: 1451-1463
[68]
161 Tomova A, Husarova V, Lakatosova S, et al. Gastrointestinal microbiota in children with autism in Slovakia. Physiol Behav, 2015, 138: 179-187
[69]
162 DO R W, Roberts E, Sichel L S, et al. Improvements in gastrointestinal symptoms among children with autism spectrum disorder receiving the Delpro？ probiotic and immunomodulator formulation. Prob Health, 2013, 1: 102
[70]
163 Tabbers M M, de Milliano I, Roseboom M G, et al. Is Bifidobacterium breve effective in the treatment of childhood constipation? Results from a pilot study. Nutr J, 2011, 10: 19
[71]
164 Xu Z, Knight R. Dietary effects on human gut microbiome diversity. Br J Nutr, 2015, 113: S1-S5
[72]
165 Walsh C J, Guinane C M, O’Toole P W, et al. Beneficial modulation of the gut microbiota. FEBS Lett, 2014, 588: 4120-4130
[73]
166 David L A, Maurice C F, Carmody R N, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature, 2014, 505: 559-563
[74]
167 Nam Y, Jung M, Roh S W, et al. Comparative analysis of Korean human gut microbiota by barcoded pyrosequencing. PLoS One, 2011, 6: e22109
[75]
168 De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA, 2010, 107: 14691-14696
[76]
169 Guarner F, Malagelada J R. Gut flora in health and disease. Lancet, 2003, 361: 512-519
[77]
170 Hamer H M, Jonkers D, Venema K, et al. Review article: The role of butyrate on colonic function. Aliment Pharmacol Ther, 2008, 27: 104-119
[78]
171 Gottschall E. Digestion-gut-autism connection: The specific carbohydrate diet. Med Veritas, 2004, 1: 261-271
[79]
172 McBride N C. Gut and psychology syndrome diet, The GAPS diet. http://www.gapsdiet.com/Resources.html2003
[80]
173 Qu F, Weischler L B, Sundell J, et al. Increasing prevalence of asthma and allergy in Beijing pre-school children: Is exclusive breastfeeding for more than 6 months protective? (in Chinese). Chin Sci Bull, 2013, 58: 2513-2526 [屈芳, Weischler L B, Sundell J, 等. 纯母乳喂养对北京学龄前儿童哮喘和过敏性疾病患病率的影响. 科学通报, 2013, 58: 2513-
[81]
174 Le Hu？rou-Luron I, Blat S, Boudry G. Breastvs. formula-feeding: Impacts on the digestive tract and immediate and long-term health effects. Nutr Res Rev, 2010, 23: 23-36
[82]
175 Gueimonde M, Laitinen K, Salminen S, et al. Breast milk: A source of Bifidobacteria for infant gut development and maturation? Neonatol, 2007, 92: 64-66
[83]
176 Midtvedt T. The gut: A triggering place for autism possibilities and challenges. Microb Ecol Health Dis, 2012, 23: 18982
[84]
177 Lai M C, Lombardo M V, Baron-Cohen S. Autism. Lancet, 2014, 383: 896-910
[85]
178 Levy S E, Mandell D S, Schultz R T. Autism. Lancet, 2009, 374: 1627-1638
[86]
179 Patel R M, Denning P W. Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: What is the current evidence? Clin Perinatol, 2013, 40: 11-25
[87]
180 Aroniadis O C, Brandt L J. Fecal microbiota transplantation: Past, present and future. Curr Opin Gastroenterol, 2013, 29: 79-84
[88]
181 Kawicka A, Regulska-Ilow B. How nutritional status, diet and dietary supplements can affect autism. A review. Rocz Panstw Zakl Hig, 2013, 64: 1-12
[89]
182 Anagnostou E, Hansen R. Medical treatment overview: Traditional and novel psycho-pharmacological and complementary and alternative medications. Curr Opin Pediat, 2011, 23: 621-627
[90]
183 McDonald D, Hornig M, Lozupone C, et al. Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients. Microb Ecol Health Dis, 2015, 26: 26555
[91]
80 Trajkovski V, Petlichkovski A, Efinska Mladenovska O, et al. Higher plasma concentration of food-specific antibodies in persons with autistic disorder in comparison to their siblings. Focus Autism Other Dev Stud, 2008, 23: 176-185
[92]
81 Filiano A J, Gadani S P, Kipnis J. Interactions of innate and adaptive immunity in brain development and function. Brain Res, 2014, doi: 10.1016/j.brainres.2014.07.050
[93]
82 Licinio J, Alvarado I, Wong M L. Autoimmunity in autism. Mol Psychiatry, 2002, 7: 375-382
[94]
83 Samsam M, Ahangari R, Naser S A. Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance. World J Gastroenterol, 2014, 20: 9942-9951
[95]
84 Comi A M, Zimmerman A W, Frye V H, et al. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol, 1999, 14: 388-394
[96]
85 Licinio J, Wong M. The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection. Mol Psychiatry, 1999, 4: 317-327
[97]
86 Cohly H H, Panja A. Immunological findings in autism. Int rev neurobiol, 2005, 71: 317-341
[98]
87 Hashim H, Abdelrahman H, Mohammed D, et al. Association between plasma levels of transforming growth factor-b1, IL-23 and IL-17 and the severity of autism in Egyptian children. Res Autism Spe Dis, 2013, 7: 199-204
[99]
104 Rowland I R, Davies M J, Evans J G. Tissue content of mercury in rats given methylmercuric chloride orally: Influence of intestinal flora. Arch Environ Health, 1980, 35: 155-160
[100]
105 Madsen K M, Hviid A, Vestergaard M, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med, 2002, 347: 1477-1482
[101]
106 Parker S K, Schwartz B, Todd J, et al. Thimerosal-containing vaccines and autistic spectrum disorder: A critical review of published original data. Pediatrics, 2004, 114: 793-804
[102]
107 Furness J B. The Enteric Nervous System. Hoboken: Blackwell Publishing, 2007
[103]
108 Gershon M. The second brain: A Groundbreaking New Understanding of Nervous Disorders of the Stomach and Intestine. New York: HarperCollins Publishers, Inc., 1999
[104]
109 Grenham S, Clarke G, Cryan J F, et al. Brain gut microbe communication in health and disease. Front Physiol, 2011, 2: 1-15
[105]
110 Forsythe P, Sudo N, Dinan T, et al. Mood and gut feelings. Brain Behav Immun, 2010, 24: 9-16
[106]
111 Luo J, Jin F. Recent advances in understanding the impact of intestinal microbiota on host behavior (in Chinese). Chin Sci Bull, 2014, 59: 2169-2190 [罗佳, 金锋. 肠道菌群影响宿主行为的研究进展. 科学通报, 2014, 59: 2169-
[107]
112 Mayer E A, Padua D, Tillisch K. Altered brain-gut axis in autism: Comorbidity or causative mechanisms? BioEssays, 2014, 36: 933-939
[108]
113 van De Sande M M H, van Buul V J, Brouns F J P H. Autism and nutrition: The role of the gut-brain axis. Nutr Res Rev, 2014, 27: 199-214
[109]
114 O’Hara A M, Shanahan F. The gut flora as a forgotten organ. EMBO Rep, 2006, 7: 688-693
[110]
115 Zhu B, Wang X, Li L. Human gut microbiome: The second genome of human body. Protein Cell, 2010, 1: 718-725
[111]
116 Gill S R, Pop M, DeBoy R T, et al. Metagenomic analysis of the human distal gut microbiome. Science, 2006, 312: 1355-1359
[112]
117 Compare D, Coccoli P, Rocco A, et al. Gut-liver axis: The impact of gut microbiota on non alcoholic fatty liver disease. Nutri Metab Cardiovasc Dis, 2012, 22: 471-476
[113]
118 Hood L. Tackling the microbiome. Science, 2012, 336: 1209
[114]
119 Clemente J C, Ursell L K, Parfrey L W, et al. The impact of the gut microbiota on human health: An integrative view. Cell, 2012, 148: 1258-1270
[115]
120 Finegold S M, Molitoris D, Song Y, et al. Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis, 2002, 35: S6-S16
[116]
121 Shreiner A B, Kao J Y, Young V B. The gut microbiome in health and in disease. Curr Opin Gastroenterol, 2015, 31: 69-75
[117]
122 Heijtz R D, Wang S, Anuar F, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA, 2011, 108: 3047-3052
[118]
123 Liang S, Wang T, Hu X, et al. Microorganism and behavior and psychiatric disorders (in Chinese). Adv Psych Sci, 2012, 20: 75-97 [梁姗, 王涛, 胡旭, 等. 微生物与行为和精神疾病. 心理科学进展, 2012, 20: 75-
[119]
124 Foster J A, McVey Neufeld K A. Gut-brain axis: How the microbiome influences anxiety and depression. Trends Neurosci, 2013, 36: 305-312
[120]
125 Cryan J F, O’Mahony S M. The microbiome-gut-brain axis: From bowel to behavior. Neurogastroenterol Motil, 2011, 23: 187-192
[121]
126 O’Mahony S M, Clarke G, Borre Y E, et al. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res, 2015, 277: 32-48
[122]
127 Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature, 2011, 473: 174-180
[123]
128 Wu G D, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science, 2011, 334: 105-108
[124]
129 Kang D W, Park J G, Ilhan Z E, et al. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS One, 2013, 8: e68322
[125]
130 Koenig J E, Spor A, Scalfone N, et al. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci USA, 2011, 108: 4578-4585
[126]
131 Borre Y E, O’Keeffe G W, Clarke G, et al. Microbiota and neurodevelopmental windows: Implications for brain disorders. Trends Mol Med, 2014, 20: 509-518
[127]
132 Aagaard K, Ma J, Antony K M, et al. The placenta harbors a unique microbiome. Sci Transl Med, 2014, 6: 237-265
[128]
133 Francis S S, Selvin S, Metayer C, et al. Mode of delivery and risk of childhood leukemia. Cancer Epidemiol Biomarkers Prev, 2014, 23: 876-881
[129]
134 Neu J. The pre-and early postnatal microbiome: Relevance to subsequent health and disease. Neoreviews, 2013, 14: e592-e599
[130]
135 Breitbart M, Haynes M, Kelley S, et al. Viral diversity and dynamics in an infant gut. Res Microbiol, 2008, 159: 367-373
[131]
136 Dominguez-Belloa M G, Costellob E K, Contrerasc M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA, 2010, 107: 11971-11975
[132]
137 Gao J, Song H, Duan Y H, et al. Antenatal and postnatal situation survey of 202 cases children with autism and its influential factors in Shenzhen city (in Chinese). Chin J Child Care, 2015, 23: 319-321 [高建, 宋慧, 段永恒, 等. 深圳市202例孤独症儿童出生前后状况调查及影响因素分析. 中国儿童保健杂志, 2015, 23: 319-
[133]
138 Schwartz S, Friedberg I, Ivanov I V, et al. A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response. Genome Biol, 2012, 13: r32
[134]
139 Rosenfeld C S. Microbiome disturbances and autism spectrum disorders. Drug Metab Dispos, 2015, pii: dmd.115.063826
[135]
140 Toh M C, Allen-Vercoe E. The human gut microbiota with reference to autism spectrum disorder: Considering the whole as more than a sum of its parts. Microb Ecol Health Dis, 2015, 26: 26309
[136]
141 Song Y, Liu C, Molitoris D R, et al. Clostridium bolteae sp. nov., isolated from human sources. Syst Appl Microbiol, 2003, 26: 84-89
[137]
142 Song Y, Liu C, Finegold S M. Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol, 2004, 70: 6459-6465
[138]
143 Parracho H M, Bingham M O, Gibson G R, et al. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol, 2005, 54: 987-991
[139]
144 Sandler R H, Finegold S M, Bolte E R, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol, 2000, 15: 429-435
[140]
145 Finegold S M. State of the art; microbiology in health and disease. Intestinal bacterial flora in autism. Anaerobe, 2011, 17: 367-368
[141]
146 Finegold S M, Downes J, Summanen P H. Microbiology of regressive autism. Anaerobe, 2012, 18: 260-262
[142]
38 Keunen K, van Elburg R M, van Bel F, et al. Impact of nutrition on brain development and its neuroprotective implications following preterm birth. Pediatr Res, 2015, 77: 148-155
[143]
39 Chez M G, Buchanan C P, Aimonovitch M C, et al. Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders. J Child Neurol, 2002, 17: 833-837
[144]
40 Dolske M C, Spollen J, McKay S, et al. A preliminary trial of ascorbic acid as supplemental therapy for autism. Prog Neuropsychopharmacol Biol Psychiatry, 1993, 17: 765-774
[145]
41 Buie T, Campbell D B, Fuchs G J, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: A consensus report. Pediatrics, 2010, 125: S1-S18
[146]
42 Wakefield A J, Anthony A, Murch S H, et al. Enterocolitis in children with developmental disorders. Am J Gastroenterol, 2000, 95: 2285-2295
[147]
43 White J F. Intestinal pathophysiology in autism. Exp Biol Med, 2003, 228: 639-649
[148]
44 de Magistris L, Picardi A, Siniscalco D, et al. Antibodies against food antigens in patients with autistic spectrum disorders. Biomed Res Int, 2013, 2013: 729349
[149]
45 Horvath K, Papadimitriou J C, Rabsztyn A, et al. Gastrointestinal abnormalities in children with autistic disorder. J Pediatrics, 1999, 135: 559-563
[150]
46 Wakefield A J, Puleston J M, Montgomery S M, et al. The concept of entero-colonic encephalopathy, autism and opioid receptor ligands. Aliment Pharmacol Ther, 2002, 16: 663-674
[151]
47 de Magistris L, Familiari V, Pascotto A, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatric Gastroenterol Nutr, 2010, 51: 418-424
[152]
48 Adams J B, Audhya T, McDonough Means S, et al. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutr Metab, 2011, 8: 1
[153]
49 Wang L, Christophersen C T, Sorich M J, et al. Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Dig Dis Sci, 2012, 57: 2096-2102
[154]
50 Johnson C, Handen B, Zimmer M, et al. Effects of gluten free/casein free diet in young children with autism: A pilot study. J Dev Phys Disabil, 2011, 23: 213-225
[155]
51 Cornish E. Gluten and casein free diets in autism: A study of the effects on food choice and nutrition. J Hum Nutr Diet, 2002, 15: 261-269
[156]
52 Knivsberg A M, Reichelt K L, H？ien T, et al. A randomised, controlled study of dietary intervention in autistic syndromes. Nutr Neurosci, 2002, 5: 251-261
[157]
53 Whiteley P, Shattock P, Knivsberg A M, et al. Gluten-and casein-free dietary intervention for autism spectrum conditions. Front Hum Neurosci, 2012, 6: 344
[158]
54 Goin-Kochel R P, Mackintosh V H, Myers B J. Parental reports on the efficacy of treatments and therapies for their children with autism spectrum disorders. Res Autism Spectr Disord, 2009, 3: 528-537
[159]
55 Elder J H. The gluten-free, casein-free diet in autism: An overview with clinical implications. Nutr Clin Pract, 2008, 23: 583-588
[160]
56 Pedersen L, Parlar S, Kvist K, et al. Data mining the ScanBrit study of a gluten-and casein-free dietary intervention for children with autism spectrum disorders: Behavioural and psychometric measures of dietary response. Nutr Neurosci, 2013, 17: 207-213
[161]
57 Whiteley P. Nutritional management of (some) autism: A case for gluten-and casein-free diets? Proc Nutr Soc, 2014, 14: 1-6
[162]
58 Millward C, Ferriter M, Calver S, et al. Gluten-free and casein-free diets for autistic spectrum disorder. Cochrane Database Syst Rev, 2008, 2: CD003498
[163]
59 Boccuto L, Chen C F, Pittman A, et al. Decreased tryptophan metabolism in patients with autism spectrum disorders. Mol Autism, 2013, 4: 16
[164]
60 Scott M M, Deneris E S. Making and breaking serotonin neurons and autism. Int J Dev Neurosci, 2005, 23: 277-285
[165]
61 Chugani D C, Muzik O, Behen M, et al. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann Neurol, 1999, 45: 287-295
[166]
62 Burgess N, Sweeten T, McMahon W, et al. Hyperserotoninemia and altered immunity in autism. J Autism Dev Disord, 2006, 36: 697-704
[167]
63 Yang C J, Tan H P, Du Y J. The developmental disruptions of serotonin signaling may involved in autism during early brain development. Neuroscience, 2014, 267: 1-10
[168]
64 Nakamura K, Sekine Y, Ouchi Y, et al. Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. Arch Gen Psychiatry, 2010, 67: 59-68
66 Stone T W, Darlington L G. Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov, 2002, 1: 609-620
[171]
67 Geier D A, Kern J K, Garver C R, et al. A prospective study of transsulfuration biomarkers in autistic disorders. Neurochem Res, 2009, 34: 386-393
[172]
68 Waring R H, Klovrza L V. Sulphur metabolism in autism. J Nutr Env Med, 2000, 10: 25-32
[173]
69 Frye R E, James S J. Metabolic pathology of autism in relation to redox metabolism. Biomarker Med, 2014, 8: 321-330
[174]
70 Gruber K, Kratky C. Cobalamin-dependent Methionine Synthase. Handbook of Metalloproteins. Hoboken: John Wiley & Sons, Ltd, 2006
[175]
71 Kern J K, Jones A M. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J Toxicol Environ Health B Crit Rev, 2006, 9: 485-499
[176]
72 Deth R, Muratore C, Benzecry J, et al. How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology, 2008, 29: 190-201
[177]
73 Jill James S, Melnyk S, Jernigan S, et al. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev Disord, 2008, 38: 1966-1975
[178]
74 Field D, Garland M, Williams K. Correlates of specific childhood feeding problems. J Paediatr Child Health, 2003, 39: 299-304
[179]
75 Filipek P, Juranek J, Nguyen M, et al. Relative carnitine deficiency in autism. J Autism Dev Disord, 2004, 34: 615-623
[180]
76 Chugani D C, Sundram B S, Behen M, et al. Evidence of altered energy metabolism in autistic children. Prog Neuropsychopharmacol Biol Psychiatry, 1999, 23: 635-641
78 Shultz S R, MacFabe D F, Ossenkopp K P, et al. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: Implications for an animal model of autism. Neuropharmacol, 2008, 54: 901-911
[183]
79 Li S S, Jia M X, Sun Z G, et al. The clinical effects of fasting sensitive food in patients with autism spectrum disorders (in Chinese). Int J Psychiatry, 2015, 42: 23-26 [李素水, 贾美香, 孙志刚, 等. 禁食敏感食物对孤独症谱系障碍患者的临床疗效研究. 国际精神病学杂志, 2015, 42: 23-
