13 Wood K W, Lad L, Luo L, et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci USA, 2010, 107: 5839-5844
[6]
24 Yen T J, Li G, Schaar B T, et al. CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature, 1992, 359: 536-539
[7]
25 Wood K W, Sakowicz R, Goldstein L S, et al. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell, 1997, 91: 357-366
[8]
28 Yao X, Abrieu A, Zheng Y, et al. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol, 2000, 2: 484-491
[9]
34 Putkey F R, Cramer T, Morphew M K, et al. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell, 2002, 3: 351-365
[10]
37 Yao X, Fang G. Visualization and orchestration of the dynamic molecular society in cells. Cell Res, 2009, 19: 152-155
[11]
38 Gudimchuk N, Vitre B, Kim Y, et al. Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nat Cell Biol, 2013, 15: 1079-1088
[12]
39 Chung V, Heath E I, Schelman W R, et al. First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere- associated protein E (CENP-E), in patients with refractory cancer. Cancer Chemother Pharmacol, 2012, 69: 733-741
[13]
40 Torres J Z, Summers M K, Peterson D, et al. The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. Cell, 2011, 147: 1309-1323
[14]
43 Cai S, Weaver L N, Ems-McClung S C, et al. Proper organization of microtubule minus ends is needed for midzone stability and cytokinesis. Curr Biol, 2010, 20: 880-885
[15]
45 Jang C Y, Coppinger J A, Seki A, et al. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci, 2009, 122: 1334-1341
[16]
46 Cimini D, Moree B, Canman J C, et al. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. J Cell Sci, 2003, 116: 4213-4225
[17]
47 Aoki S, Ohta K, Yamazaki T, et al. Mammalian mitotic centromere-associated kinesin (MCAK): A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents. FEBS J, 2005, 272: 2132-2140
[18]
51 Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, et al. Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle. EMBO J, 1996, 15: 457-467
[19]
52 Levesque A A, Compton D A. The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J Cell Biol, 2001, 154: 1135-1146
[20]
53 Stumpff J, von Dassow G, Wagenbach M, et al. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev Cell, 2008, 14: 252-262
[21]
54 Catarinella M, Gruner T, Strittmatter T, et al. BTB-1: A small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl, 2009, 48: 9072-9076
[22]
55 Eggert U S, Mitchison T J, Field C M. Animal cytokinesis: From parts list to mechanisms. Annu Rev Biochem, 2006, 75: 543-566
[23]
56 Nislow C, Lombillo V A, Kuriyama R, et al. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. Nature, 1992, 359: 543-547
[24]
57 Mishima M, Kaitna S, Glotzer M. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev Cell, 2002, 2: 41-54
[25]
58 Echard A, Jollivet F, Martinez O, et al. Interaction of a Golgi-associated kinesin-like protein with Rab6. Science, 1998, 279: 580-585
[26]
59 Hummer S, Mayer T U. Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex. Curr Biol, 2009, 19: 607-612
[27]
60 Tcherniuk S, Skoufias D A, Labriere C, et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl, 2010, 49: 8228-8231
[28]
61 Ha T. Single-molecule approaches embrace molecular cohorts. Cell, 2013, 154: 723-726
[29]
1 Jordan M A, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer, 2004, 4: 253-265
[30]
3 Kavallaris M. Microtubules and resistance to tubulin-binding agents. Nat Rev Cancer, 2010, 10: 194-204
[31]
4 Wood K W, Cornwell W D, Jackson J R. Past and future of the mitotic spindle as an oncology target. Curr Opin Pharmacol, 2001, 1: 370-377
[32]
5 Wordeman L. How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays. Semin Cell Dev Biol, 2010, 21: 260-268
[33]
9 Hirokawa N, Niwa S, Tanaka Y. Molecular motors in neurons: Transport mechanisms and roles in brain function, development, and disease. Neuron, 2010, 68: 610-638
[34]
10 Lawrence C J, Dawe R K, Christie K R, et al. A standardized kinesin nomenclature. J Cell Biol, 2004, 167: 19-22
[35]
11 Mayer T U, Kapoor T M, Haggarty S J, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science, 1999, 286: 971-974
[36]
12 Straight A F, Cheung A, Limouze J, et al. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science, 2003, 299: 1743-1747
[37]
14 Ding X, Yan F, Yao P, et al. Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res, 2010, 20: 1386-1389
[38]
15 Blangy A, Lane H A, d'Herin P, et al. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell, 1995, 83: 1159-1169
[39]
16 Kantarjian H M, Padmanabhan S, Stock W, et al. Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia. Invest New Drugs, 2012, 30: 1107-1115
[40]
17 Infante J R, Kurzrock R, Spratlin J, et al. A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors. Cancer Chemother Pharmacol, 2012, 69: 165-172
[41]
18 Kwok B H, Kapitein L C, Kim J H, et al. Allosteric inhibition of kinesin-5 modulates its processive directional motility. Nat Chem Biol, 2006, 2: 480-485
[42]
19 Valentine M T, Fordyce P M, Krzysiak T C, et al. Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro. Nat Cell Biol, 2006, 8: 470-476
[43]
20 Burris H A, Jones S F, Williams D D, et al. A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors. Invest New Drugs, 2011, 29: 467-472
[44]
21 Blagden S P, Molife L R, Seebaran A, et al. A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours. Br J Cancer, 2008, 98: 894-899
[45]
22 Rath O, Kozielski F. Kinesins and cancer. Nat Rev Cancer, 2012, 12: 527-539
[46]
23 Yen T J, Compton D A, Wise D, et al. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J, 1991, 10: 1245-1254
[47]
26 Yucel J K, Marszalek J D, McIntosh J R, et al. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. J Cell Biol, 2000, 150: 1-11
[48]
27 Yao X, Anderson K L, Cleveland D W. The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules. J Cell Biol, 1997, 139: 435-447
[49]
29 Mao Y, Desai A, Cleveland D W. Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol, 2005, 170: 873-880
[50]
30 Kim Y, Holland A J, Lan W, et al. Aurora kinases and protein phosphatase1 mediate chromosome congression through regulation of CENP-E. Cell, 2010, 142: 444-455
[51]
31 Chan G K, Jablonski S A, Sudakin V, et al. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J Cell Biol, 1999, 146: 941-954
[52]
32 Huang Y, Wang W, Yao P, et al. CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis. J Biol Chem, 2012, 287: 1500-1509
[53]
33 Wang X, Zhuang X, Cao D, et al. Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules. J Biol Chem, 2012, 287: 39380-39390
[54]
35 Weaver B A, Cleveland D W. Aneuploidy: Instigator and inhibitor of tumorigenesis. Cancer Res, 2007, 67: 10103-10105
[55]
36 Weaver B A, Silk A D, Montagna C, et al. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell, 2007, 11: 25-36
[56]
41 Ando A, Kikuti Y Y, Kawata H, et al. Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region. Immunogenetics, 1994, 39: 194-200
[57]
42 DeLuca J G, Newton C N, Himes R H, et al. Purification and characterization of native conventional kinesin, HSET, and CENP-E from mitotic hela cells. J Biol Chem, 2001, 276: 28014-28021
[58]
44 Kwon M, Godinho S A, Chandhok N S, et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev, 2008, 22: 2189-2203
[59]
48 Mazumdar M, Misteli T. Chromokinesins: multitalented players in mitosis. Trends Cell Biol, 2005, 15: 349-355
[60]
49 Zhu C, Zhao J, Bibikova M, et al. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell, 2005, 16: 3187-3199
[61]
50 Mazumdar M, Lee J H, Sengupta K, et al. Tumor formation via loss of a molecular motor protein. Curr Biol, 2006, 16: 1559-1564