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菌物学报  2015 

鲍姆氏层孔菌子实体中化合物的分离鉴定及其体外抑制肿瘤的研究

DOI: 10.13346/j.mycosystema.130238, PP. 124-130

Keywords: 食药用真菌,次级代谢产物,分离纯化,生物活性

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Abstract:

鲍姆氏层孔菌Phellinusbaumii子实体中分离得到的化合物,通过波谱分析,分别鉴定为:麦角甾-7,22-二烯-3β-醇十五烷酸酯(1),星鱼甾醇(2),灵芝醇B(3),麦角甾-6,22-二烯-3β,5α,8α-三醇(4),灵芝酸DM(5)和InoscavinA(6)。化合物1、2、3、4、5为首次从Phellinusbaumii子实体中获得。对化合物进一步作了体外抗肿瘤实验,结果表明,化合物1、2、4、5、6对肿瘤细胞K562的增殖有不用程度的抑制作用,其抑制率IC50值分别为63.5、10.3、70.6、35.9和3.5μg/mL。化合物5对肿瘤细胞HepG2也有明显的抑制作用,其抑制率IC50值为50.3μg/mL。

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