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菌物学报  2015 

侧耳属真菌次级代谢产物化学及其生物学活性研究进展

DOI: 10.13346/j.mycosystema.150068, PP. 569-580

Keywords: 侧耳属,食用真菌,药用真菌,次级代谢产物,药用活性

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Abstract:

对侧耳属真菌次级代谢产物的化学及其生物学活性进展进行了综述。化学研究表明侧耳属真菌中蕴含有萜类、甾体类、酚酸衍生物、聚炔等多种结构类型的天然产物,这些化合物所具有的生物活性包括抗细菌、抗线虫、抗炎和抗肿瘤等。作用机制研究表明截短侧耳素类物质通过抑制肽酰转移酶活性而产生强抗菌作用;pleurotonB通过Bax/Bak通路诱导肿瘤细胞凋亡。

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