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化工学报  2015 

硫酸氢氯吡格雷球形结晶工艺及其生长机理

DOI: 10.11949/j.issn.0438-1157.20151084, PP. 3633-3639

Keywords: 硫酸氢氯吡格雷,多晶型,球形结晶,生长机理

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Abstract:

本文测定了硫酸氢氯吡格雷Ⅰ、Ⅱ晶型在仲丁醇中的溶解度,通过过程分析和优化,制备了纯Ⅰ晶型的硫酸氢氯吡格雷球形晶体。与非球形晶体比较,球形晶体在堆密度、流动性、粒度分布以及稳定性等方面均占优势。本文考察了不同温度、残留溶剂对硫酸氢氯吡格雷晶习与晶型的影响,研究了硫酸氢氯吡格雷球形结晶过程晶体的生长机理。

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