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化工学报  2015 

2,4-二氯-5-氟嘧啶的合成及废液回收处理利用

DOI: 10.11949/j.issn.0438-1157.20141261, PP. 1723-1729

Keywords: 5-氟尿嘧啶,缚酸剂,合成,废水,回收,水合物

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Abstract:

使用5-氟尿嘧啶(5-FU)和三氯氧磷(POCl3)作为原料、N,N-二甲基苯胺(DMA)作为缚酸剂合成2,4-二氯-5-氟嘧啶,系统研究了5-FU与POCl3的摩尔比、5-FU与DMA的摩尔比、反应温度和反应时间对反应收率的影响,简要阐述该反应机理。反应结束后,向废液中加入NaOH固体对废液进行处理,探讨DMA的回收率和副产物磷酸氢二钠的收率与pH的关系。结果表明,在工艺参数为5-FU与POCl3的摩尔比为1:10、5-FU与DMA的摩尔比为1:1.5、回流温度114℃、回流时间2h时,2,4-二氯-5-氟嘧啶的收率为92.2%;通过加入NaOH固体将废液pH调至7,DMA的回收率和副产物磷酸氢二钠的收率都为最大值。

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