全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
化工学报  2015 

异步控制Varicol工艺分离愈创木酚甘油醚对映体过程研究

DOI: 10.11949/j.issn.0438-1157.20140996, PP. 157-163

Keywords: 愈创木酚甘油醚,分离,模拟移动床,Varicol,工艺,模型,色谱

Full-Text   Cite this paper   Add to My Lib

Abstract:

模拟移动床技术已经成为手性化合物拆分的重要手段。以ChiralcelOD为固定相、乙醇/正己烷混合物为流动相,采用一种先进的模拟移动床技术(Varicol工艺)分离愈创木酚甘油醚对映体。针对进出料口位置异步切换模式建立了Varicol工艺数学模型,采用有限元正交配置法对模型进行求解。从初始循环内愈创木酚甘油醚对映体内部浓度的时间进程曲线分析了Varicol工艺的分离过程。并且设计了5柱(1-1.5-1.5-1)构态的Varicol工艺分离愈创木酚甘油醚操作区,确定了获得单一对映体产品纯度99%的分离条件,通过实验数据进行了验证。理论和实验研究可以为Varicol工艺的工业应用提供基础依据。

References

[1]  Rajendran A, Paredes Galatea, Mazzotti M. Simulated moving bed chromatography for the separation of enantiomers [J]. Journal of Chromatograpy A, 2009, 1216: 709-738
[2]  Li P, Xiu G H, Rodrigues A E. Proteins separation and purification by salt gradient ion-exchange SMB [J]. AIChE Journal, 2007, 53: 2419-2431
[3]  Migliorini C, Wendlinger M, Mazzotti M, Morbidelli M. Temperature gradient operation of a simulated moving bed unit [J]. Industrial Engineering Chemistry Research, 2001, 40: 2606-2617
[4]  Peper S, Lubbert M, Johannsen M, Brunner G. Separation of ibuprofen enantiomers by supercritical fluid simulated moving bed chromatography [J]. Separation Science and Technology, 2002, 37: 2545-2566
[5]  Toumi A, Hanisch F, Engell S. Optimal operation of continuous chromatographic processes: mathematical optimization of the VARICOL process [J]. Industrial & Engineering Chemistry Research, 2002, 41: 4328-4337
[6]  Zhang Z Y, Mazzotti M, Morbidelli M. Power feed operation of simulated moving bed units: changing flow-rates during the switching interval [J]. Journal of Chromatography A, 2003, 1006: 87-99
[7]  Gong R J, Lin X J, Li P, Yu J G, Rodrigues A E. Adsorption equilibrium and kinetic study of guaifenesin enantiomers on cellulose tris 3,5-dimethylphenylcarbamate packed column [J]. Chemical Engineering Journal, 2014, 244: 128-136
[8]  Li Ling (李凌), Jing Yuanwei (井元伟), Yuan Decheng (袁德成). Simulated moving bed adsorption separation technology and its applications [J]. Computers and Applied Chemistry (计算机与应用化学), 2007, 24 (4): 441-444
[9]  Cai Yujie (蔡宇杰), Ding Yanrui (丁彦蕊), Zhang Dabing (张大兵), Dai Jun (戴军), Shi Guiyang (石贵阳), Xu Wenbo (须文波). Simulated moving bed technology and its applications [J]. Chinese Journal of Chromatography (色谱), 2004, 22 (2): 111-115
[10]  Wei Feng (危风), Shen Bo (沈波), Chen Mingjie (陈明杰), Zhou Xianbo (周先波), Wu Pingdong (吴平东). Omeprazole resolution by simulated moving bed chromatography [J]. Journal of Chemical Industry and Engineering (China) (化工学报), 2005, 56 (9): 1699-1702
[11]  Schramm H, Kaspereit M, Kienle A, Seidel-Morgenstern A. Simulated moving bed process with cyclic modulation of the feed concentration [J]. Journal of Chromatography A, 2003, 1006: 77-86
[12]  Shen B, Chen M J, Jiang H L, Zhao Y X, Wei F. Modeling study on a Three-zone simulated moving bed without zone Ⅰ [J]. Separation Science and Technology, 2011, 46: 695-701
[13]  Wang X, Ching C B. Chiral separation of beta-blocker drug (nadolol) by five zone simulated moving bed chromatography [J]. Chemical Engineering Science, 2005, 60: 1337-1347
[14]  Wankat P C. Simulated moving bed cascades for ternary separations [J]. Industrial & Engineering Chemistry Research, 2001, 40: 6185-6193
[15]  Lorenz H, Sheehan P, Seidel-Morgenstern A. Coupling of simulated moving bed chromatography and fractional crystallization for efficient enantioseparation [J]. Journal of Chromatography A, 2001, 908: 201-214
[16]  Ludemann-hombourger O, Nicoud R M. The “varicol” process: a new multicolumn continuous chromatographic process [J]. Separation Science and Technology, 2000, 35: 1829-1862
[17]  Ludemann-Hombourger O, Pigorini G, Nicoud R M, Terfloth G. Application of the ""VARICOL"" process to the separation of the isomers of the SB-553261 racemate [J]. Journal of Chromatography A, 2002, 947: 59-68
[18]  Toumi A, Engell S, Ludemann-Hombourger O, Nicoud R M, Bailly M. Optimization of simulated moving bed and Varicol processes [J]. Journal of Chromatography A, 2003, 1006: 15-31
[19]  Zhang Y, Hidajat K, Ray A K, Morbidelli M. Multiobjective optimization of SMB and Varicol process for chiral separation [J]. AIChE Journal, 2002, 48: 2800-2816
[20]  Zhang Y, Hidajat K, Ray A K. Multi-objective optimization of simulated moving bed and Varicol processes for enantio-separation of racemic pindolol [J]. Separation and Purification Technology, 2009, 65: 311-321
[21]  Da Silva A C, Salles A C, Perna R F, Correia C R D, Santana C C. Chromatographic separation and purification of mitotane racemate in a Varicol multicolumn continuous process [J]. Chemical Engineering Technology, 2012, 35: 83-90
[22]  Rodrigues R C R, Araujo J M M, Eusebio M F J, Mota J P B. Experimental of assessment of simulated moving bed and Varicol processes using a single-column setup [J]. Journal of Chromatography A, 2007, 1142: 69-80
[23]  Huang Yongdong (黄永东), Jiang Heyuan (江河源), Jiang Yongwen (江用文), Zhang Jianyong (张建勇), Wang Bin (王斌), Bai Yan (白艳), Wen Zhihao (文志浩), Wang Weiwei (王伟伟). Comparison of Varicol and partial-discard process with traditional process to purify ECG and EGCG from green tea polyphenols using simulated moving bed chromatography [J]. Journal of Tea Science (茶叶科学), 2011, 31 (3): 201-210
[24]  Lu J G. Numerical simulation of asynchronous simulated moving bed chromatography [J]. Chinese Journal of Chemical Engineering, 2004, 12: 415-420
[25]  Xiao Di (肖迪), Ge Qicheng (葛启承), Lin Jinguo (林锦国). Dynamic simulation of simulated moving bed based on Vericol [J]. Computers and Applied Chemistry (计算机与应用化学), 2012, 29: 567-570
[26]  Gong R J, Lin X J, Li P, Yu J G, Rodrigues A E. Experiment and modeling for the separation of guaifenesin enantiomers using simulated moving bed and Varicol units [J]. Journal of Chromatography A, 2014, 1363: 242-249
[27]  Yang Minglei (杨明磊), Wei Min (魏民), Hu Rong (胡蓉), Ye Zhencheng (叶贞成), Qian Feng (钱峰). Modeling of simulated moving bed for xylene separation [J]. CIESC Journal (化工学报), 2013, 64 (12): 4335-4341
[28]  Wu Xiandong (吴献东), Jin Xiaoming (金晓明), Su Hongye (苏宏业). Multi-objective optimization of simulated moving bed chromatography separation based on NSGA-Ⅱ algorithm [J]. Journal of Chemical Industry and Engineering (China) (化工学报), 2007, 58 (8): 2038-2044
[29]  Li Ling (李凌), Yuan Decheng (袁德成), Jing Yuanwei (井元伟). Simulated moving bed process modeling and performance analysis [J]. Computers and Applied Chemistry (计算机与应用化学), 2013, 30 (11): 1289-1293
[30]  Pais L S, Rodrigues A E. Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns [J]. Journal of Chromatography A, 2003, 1006: 33-44
[31]  Pais L S, Loureiro J M, Rodrigues A E. Separation of enantiomers of a chiral epoxide by simulated moving bed chromatography [J]. Journal of Chromatography A, 1998, 827: 215-233
[32]  Zhang Y, Hidajat K, Ray A K. Enantio-separation of racemic pindolol on α1-acid glycoprotein chiral stationary phase by SMB and Varicol [J]. Chemical Engineering Science, 2007, 62: 1364-1375
[33]  Migliorini C, Mazzotti M, Morbidelli M. Simulated moving-bed units with extra-column dead volume [J]. AIChE Journal, 1999, 45: 1411-1421

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133