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高压微射流制备纳米中链脂肪酸脂质体的研究

DOI: 10.11858/gywlxb.2010.04.009, PP. 293-299

Keywords: 高压微射流,纳米脂质体,中链脂肪酸,平均粒度,包封率,稳定性系数

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Abstract:

以中链脂肪酸(MCFA)为模型材料,比较了高压微射流(HPM)、超声波和微孔过滤3种方法处理后的MCFA脂质体,着重研究了HPM的处理压力和处理次数对脂质体的平均粒度、包封率和稳定性的影响。结果表明:相比超声波和微孔过滤法,HPM处理后的MCFA脂质体的平均粒度最小、包封率最高、稳定性良好;在120MPa压力条件下处理6次时,MCFA脂质体的平均粒度达到最小,为(73.9±10.2)nm,包封率为(52.20±9.57)%;在120MPa压力条件下处理4次时,包封率和载药量达到最高,分别为(70.64±11.25)%和(9.42±0.83)%,稳定性系数最高,为0.9990±3.6951,平均粒度为(78.9±21.5)nm。

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