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可注射nanoHA/PAG/CS复合材料的制备与表征

, PP. 96-102

Keywords: 羟基磷灰石,硫酸钙,氨基酸共聚物,复合材料,降解,注射成型

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Abstract:

通过原位聚合法制备了可注射纳米羟基磷灰石/天门冬氨酸-谷氨酸共聚物/硫酸钙复合材料(HA/PAG/CS),采用FTIR、XRD、SEM对复合材料的组成结构、表面形貌及力学性能进行了表征,研究了复合材料在模拟体液(SBF)中的降解性能。结果显示:复合材料无机相羟基磷灰石、硫酸钙与有机相天门冬氨酸-谷氨酸共聚物之间存在化学相互作用,具有良好的抗压强度;7周后,复合材料在SBF中完全降解,降解方式为表面降解;在降解过程中,浸泡液的pH值在6.4~7.4之间变化;复合材料在SBF中浸泡后,其表面能够沉积磷灰石,表明复合材料具有良好的生物活性,有利于植入体与骨组织形成良好的界面结合。

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