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磷石膏/聚氨基酸医用多孔复合材料的制备与表征

, PP. 79-86

Keywords: 磷石膏,氨基酸共聚物,多孔复合材料,降解,生物活性

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Abstract:

用化学共沉淀法合成了钙磷原子比(Ca/P)为1.50和1.67的磷石膏(PG),用熔融聚合法制备四元氨基酸共聚物(PAA4),用挤出发泡法制备了两种磷石膏/四元氨基酸共聚物(PG/PAA4)多孔复合材料。通过TGA、SEM、XRD、IR、EDS等对两种复合材料的组成结构进行了表征,并研究了复合材料在磷酸缓冲液(PBS)中的体外降解性能。结果表明:无机组分PG在两种复合材料中分布均一,质量分数均为60%左右;PG/PAA4复合材料的孔径为100~400μm,孔隙率在60%左右;多孔复合材料的有机和无机相之间有化学作用。PG/PAA4复合材料具有良好的体外降解性能,其失重率随PG钙磷比的增加而增加,降解液的pH值维持在6.9~7.4之间。PG/PAA4复合材料降解后,其表面沉积了片状钙磷化合物,推测该复合材料可能具有生物活性。

References

[1]  周长忍, 丁 珊, 李立华. 可降解材料的制备及应用研究进展 [J]. 中国创伤骨骨科杂志, 2000, 2(4): 317-319. Zhou Changren, Ding Shan, Li Lihua. Degradable materials research progress of preparation and application [J]. J Orthop Trauma, 2000, 2(4): 317-319.
[2]  张国林, 吴秋华, 宋溪明, 等. 聚氨基酸共聚物合成研究进展 [J]. 高分子材料科学与工程, 2006, 22(4): 10-14. Zhang Guolin, Wu Qiuhua, Song Ximing, et al. Advance in the synthesis of poly(amino-cid)copolymers [J]. Polymer Materials Science and Engineering, 2006, 22(4): 10-14.
[3]  高建平, 游秀东, 于九皋. 聚合物/硫酸钙可吸收复合生物材料: 中国, 1392188. 2003-01-22.
[4]  严永刚, 李 鸿, 吕国玉. 氨基酸共聚物-硫酸钙复合材料及制备方法: 中国, 101560326. 2009-10-21.
[5]  Tamimi F, Kumarasami B, Doillon C, et al. Brushite-collagen composites for bone regeneration [J]. Acta Biomaterialia, 2008, 4(5): 1315-1321.
[6]  Wen H B, Cui F Z, Feng Q L, et al. Microstructural investigation of the early external callus after diaphyseal fractures of human long bone [J]. Struct Biol, 1995, 114(2): 115-122.
[7]  Cui F Z, Wen H B, Su X W, et al. Microstructures of external periosteal callus of repaired femoral fracture in children [J]. Struct Biol, 1996, 117(3): 204-208.
[8]  杜明奎, 毛克亚, 王继芳. β-磷酸三钙与α-半水硫酸钙降解研究进展 [J]. 国际骨科学杂志, 2008, 29(1): 6-7. Du Mingkui, Mao Keya, Wang Jifang.β-TCP and α-Hemihydrate calcium sulfate degradation research progress [J]. Int J Orthop, 2008, 29(1): 6-7.
[9]  Raucci M G, Antò V D’, Guarino V, et al. Biomineralized porous composite scaffolds prepared by chemical synthesis for bone tissue regeneration [J]. Acta Biomater, 2010, 4(8): 4090-4099.
[10]  严永刚, 曹 侠, 李 鸿. 多孔类骨磷灰石/聚酰胺复合材料的制备方法: 中国, 1994480. 2007-07-11.
[11]  刘永磊, 李 鸿, 吕国玉, 等. n-HA/ 多元氨基酸共聚物复合材料的制备和界面研究 [J]. 功能材料, 2010, 41(4): 566-569. Liu Yonglei, Li Hong, Lü Guoyu, et al.The study on preparation and interface of n-HA/poly(amion acid) composite [J]. Journal of Functional Materials, 2010, 41(4): 566-569.
[12]  李 鸿, 李玉宝, 严永刚, 等, 多孔n-HA/ PA-6复合材料的制备及性能 [J]. 复合材料学报, 2008, 25(1): 64-68. Li Hong, Li Yubao, Yan Yonggang, et al. Fabrication and performances of porous n-HA/PA-6 composite [J]. Acta Materiae Compositae Sinica, 2008, 25(1): 64-68.
[13]  Li Haiyan, Chang Jiang. In vitro degradation of porous degradable and bioactive PHBV/ wollastonite composite scaffolds [J]. Polymer Degradation and Stability, 2005, 87(2): 301-307.
[14]  Orava E, Korventausta J, Rosenberg M, et al. In vitro degradation of porous poly(DL-lactide-co-glycolide) (PLGA)/bioactive glass composite foams with a polar structure [J]. Polymer Degradation and Stability, 2007, 92(1): 14-23.
[15]  蓝仲薇, 李 瑛, 陈 华, 肖友发. 有机化学基础 [M]. 中国: 海洋出版社, 2004: 118-124.
[16]  李 鸿, 南景天, 吕国玉, 等. 新型可降解α-TCP/多元氨基酸共聚物复合材料制备与表征 [J]. 复合材料学报, 2010, 27(4): 26-30. Li Hong, Nan Jingtian, Lü Guoyu, et al. Novel degradable α-TCP/multi-(aminoacid) copolymer composite: Preparation and characterization [J]. Acta Materias Compositae Sinica, 2010, 27(4): 26-30.
[17]  Zou Chao, Weng Wenjian, Deng Xuliang, et al. Preparation and characterization of porous β-tricalcium phosphate/collagen composites with an integrated structure [J]. Biomaterials, 2005, 26(26): 5276-5284.
[18]  肖秀峰, 黄琼瑜, 刘榕芳, 等. 纳米羟基磷灰石/聚合物多孔复合支架材料 [J]. 复合材料学报, 2008, 25(6): 39-46. Xiao Xiufeng, Huang Qiongyu, Liu Rongfang, et al. Nano hydroxyapatite/polymer composite porous scaf foldmaterials [J]. Acta Materiae Compositae Sinica, 2008, 25(6): 39-46.
[19]  宋江凤, 刘 咏, 张 莹. 水热法合成不同形貌羟基磷灰石 [J]. 粉末冶金材料科学与工程, 2010, 15(5): 505-510. Song Jiangfeng, Liu Yong, Zhang Ying. Hydroxyapatite particles with different morphologies synthesized by hydrothermal method [J]. Materials Science and Engineering of Powder Metallurgy, 2010, 15(5): 505-510.
[20]  Jin H H, Min S H, Song Y K, et al.Degradation behavior of poly(lactide-co-glycolide)/β-TCP composites prepared using microwave energy [J]. Polymer Degradation and Stability, 2010, 95(9): 1856-1861.
[21]  薛 明, 周大利, 曹巨辉, 等. 壳聚糖/磷灰石-硅灰石复合多孔支架材料的制备与性能 [J]. 复合材料学报, 2009, 26(3): 127-132. Xue Ming, Zhou Dali, Cao Juhui, et al. Preparation and properties of the CS/AW composite as porous scaf fold material [J]. Acta Materiae Compositae Sinica, 2009, 26(3): 127-132.
[22]  Lei Y, Rai B, Ho K H, et al. In vitro degradation of novel bioactive polycaprolactone-20% tricalcium phosphate composite scaffolds for bone engineering [J]. Materials Science and Engineering, 2007, 27(2): 293-298.

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