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磷酸氢钙/氨基酸共聚物生物活性复合材料

, PP. 98-104

Keywords: 磷酸氢钙,氨基酸共聚物,复合材料,生物活性,降解

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Abstract:

通过原位聚合法制备了磷酸氢钙/四元氨基酸共聚物(DCP/PAA)复合材料,并采用XRD和IR方法对其组成结构进行了表征,用模拟体液和Tris-HCl溶液分别研究了复合材料的体外生物活性和降解性能。结果表明:DCP/PAA复合材料的无机相与有机相存在着一定的相互作用;聚合反应时间对复合材料的强度有明显的影响,反应时间越长,PAA的黏度越大,材料的抗压强度越高;复合材料具有很好的生物活性,其表面能够在模拟体液中形成磷灰石层,新形成磷灰石的Ca与P原子比为1.59,为缺钙磷灰石;复合材料能够在Tris-HCl溶液中降解,PAA的黏度对复合材料在Tris-HCl中的降解有一定的影响。复合材料浸泡在Tris-HCl溶液中,溶液的pH值在浸泡初期略有下降,但4周后稳定在7.0~7.2,与人体环境pH值接近。

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