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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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2-(烃基胺磺酰基)-5,6-二氢-二苯并[b,e]氮杂(艹卓)-6,11-二酮的合成与杀菌活性有机化学
DOI: 10.6023/cjoc201407004, PP. 2493-2498
Keywords: 5,6-二氢-二苯并[b,e]氮杂艹卓-6,11-二酮,2-烃基胺磺酰基-5,6-二氢-二苯并[b,e]氮杂艹卓-6,11-二酮,合成,杀菌活性
Abstract:
以蒽醌为原料,经Schmidt重排为5,6-二氢-二苯并[b,e]氮杂(艹卓)-6,11-二酮,再经氯磺酰化和胺化合成了一系列新颖的2-(烃基胺磺酰基)-5,6-二氢-二苯并[b,e]氮杂(艹卓)-6,11-二酮.结构经1HNMR,13CNMR和高分辨质谱确证.初步的生测结果表明,它们对棉花立枯病菌、油菜菌核病菌和芦笋茎枯病菌具有一定的杀菌活性.其中,2-(3-三氟甲基-4-溴苯基胺磺酰基)-5,6-二氢-二苯并[b,e]氮杂(艹卓)-6,11二酮(4u)对芦笋茎枯病菌有良好的杀菌活性,在50mg/mL浓度下抑制率达96.3%,与对照药剂百菌清基本相当(在50mg/mL浓度下的抑制率为98.8%).初步的构效关系分析指出,氟原子的引入有利于杀菌活性的提高.
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