OALib Journal期刊
壳聚糖酯钌络合物催化苯乙酮的不对称氢转移反应有机化学
DOI: 10.6023/cjoc201406025
Keywords: 壳聚糖 ,硬脂酸壳聚糖酯 ,不对称氢转移 ,苯乙酮
Abstract:
研究了硬脂酸壳聚糖酯(O-stearoylchitosan,SCS)与[RuCl2(p-cymene)]2原位形成催化剂对以异丙醇、甲酸钠为氢源的苯乙酮不对称氢转移反应的催化性能,考察了反应时间、温度、四氢呋喃用量等因素对催化反应的影响.硬脂酸壳聚糖酯在异丙醇/四氢呋喃的溶液中以胶束形式存在,平均胶束粒径213nm.以异丙醇为氢供体时,产物1-苯乙醇ee值可达62.9%,四氢呋喃的用量对催化活性影响较大.当异丙醇与四氢呋喃体积比为1:1时催化活性随温度升高而升高,100℃时催化反应的催化效率(TOF)值可达48.5h-1;以甲酸钠作氢源时,反应的TOF值及1-苯乙醇的ee分别可达29.4h-1及53.0%.
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