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OALib Journal期刊
ISSN: 2333-9721
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手性氨基酸衍生物的合成：硅胶促进的取代氮丙啶的开环反应有机化学
DOI: 10.6023/cjoc201307007, PP. 2545-2550
Keywords: 氨基酸,取代氮丙啶,开环反应,固相合成,X射线衍射
Abstract:
通过硅胶促进的L-氨基酸酯与取代氮丙啶的开环反应合成了一系列手性氨基酸衍生的二胺和三胺化合物，上述开环反应可被超声波加速.所得化合物的结构经1HNMR，13CNMR，IR，元素分析等手段表征.S-2-(二(2-(4-甲基苯磺酰胺乙基)胺基-3-甲基丁酸甲酯(4c)的结构经X射线单晶衍射进一步确定.L-脯氨酸甲酯(1d)与2-异丙基-N-对甲苯磺酰氮丙啶(5)发生1-3开环反应选择性形成化合物6b.
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