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OALib Journal期刊
ISSN: 2333-9721
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PPEGMEA-g-PBLG两亲性接枝共聚物的合成及其作为阿霉素输送载体的研究有机化学
DOI: 10.6023/cjoc201310043, PP. 2520-2527
Keywords: 两亲性接枝共聚物,单电子转移活性自由基聚合,阿霉素：药物载体
Abstract:
首先利用单电子转移活性自由基聚合(SET-LRP)制备了聚甲基醚聚乙二醇丙烯酸酯(PPEGMEA)主链，再通过二异丙基氨基锂(LDA)攫取羰基α-位活泼氢合成了含溴的PPEGMEA-Br，通过亲核取代反应和还原反应两步制备得到了大分子开环聚合引发剂PPEGMEA-NH2.然后采用grafting-from策略，PPEGMEA-NH2引发γ-苄基-L-谷氨酸酯五元环酸酐(BLG-NCA)的开环聚合，合成了结构规整的两亲性接枝共聚物PPEGMEA-g-PBLG.接着，以PPEGMEA-g-PBLG为药物载体，负载了阿霉素(DOX).利用紫外吸收光谱法测定了载药胶束的载药量，载药胶束的载药量最高可达到32.3%，载药胶束的体外药物释放具有很好的药物缓释特性.
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