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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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石杉碱甲的合成研究进展有机化学
DOI: 10.6023/cjoc201306006, PP. 2261-2270
Keywords: 石杉碱甲,化学合成,综述
Abstract:
石杉碱甲是中国独创的治疗老年痴呆症的药物。由于其显著的疗效，长期以来，一直受到人们的关注和研究.目前石杉碱甲在美国已经进入三期临床研究，而在中国也已获批上市并进入四期临床.由于石杉碱甲在千层塔中的含量仅为万分之一左右，且千层塔的生长周期较长，所以石杉碱甲的化学合成将成为获得该药物的一种有效途径.二十多年来，化学合成石杉碱甲从消旋化合成到手性合成，从毫克级放大到几百克级合成都体现了这一领域的长足发展.其合成工艺和路线也在安全性、实用性方面大为改善.系统综述了1989年到2013年间石杉碱甲化学合成的进展，以期为进一步完善石杉碱甲化学合成提供参考.
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