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有机化学  2013 

流动化学在药物合成中的最新进展有机化学

DOI: 10.6023/cjoc201208002, PP. 389-405

Keywords: 流动化学,微反应器,微反应技术,药物合成,多步流动合成,工艺类型

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Abstract:

作为不断成熟的一项过程强化技术,流动化学近十年来不论在学术研究还是工业应用方面均取得令人瞩目的发展;综述了流动化学技术在药物合成中的最新研发进展.当前的流动化学技术与其早期的研究相比有许多突破,例如不再局限于某类反应可行性概念的验证、越来越多的知名国际制药企业公开发展该技术以及已经有不少相关多步全合成成功案例的报道等.在简单介绍流动化学的优势、存在的挑战和应对之策之后,列举大量实例从不同工艺类型重点介绍流动化学在多步复杂药物合成工艺中的最新进展.

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