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有机化学  2014 

2,3-二取代喹唑啉-4(3H)-酮化合物的合成及生物活性研究有机化学

DOI: 10.6023/cjoc201310022, PP. 526-536

Keywords: 2,3-二取代喹唑啉-4(3H)-酮,合成,生物活性,单晶结构

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Abstract:

设计合成了一系列2,3-二取代喹唑啉-4(3H)-酮化合物,并研究了常用无机干燥剂对目标化合物合成的影响,发现无水硫酸镁能够促进2,3-二取代喹唑啉-4(3H)-酮化合物的形成.所有化合物通过核磁共振氢谱、核磁共振碳谱、高分辨质谱等方法进行结构表征,并首次报道了6-氯-3-苄氨基-2-新戊基-8-甲基喹唑啉-4(3H)-酮的单晶结构.通过生物活性测试发现部分化合物在200mg/L浓度下对小麦白粉病(Blumeriagraminis)具有较好的活体防效.

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