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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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水溶性萘酰亚胺树形分子的合成及其荧光探针性质有机化学
DOI: 10.6023/cjoc201411008, PP. 1104-1111
Keywords: 萘酰亚胺树形分子,聚集诱导荧光,荧光探针,Sn2+探针,细胞成像
Abstract:
合成了2个水溶性萘酰亚胺树形分子叔丁氧基羰基-{N,N-双{4-{{5-(4-叔丁基苯基)-[1,3,4]-噁二唑}-2-苯基}-乙烯基-1,8-萘酰亚胺}-乙氨基羰乙基}乙二胺(DON)和4-哌啶基-9-乙氨基-{N,N-双{4-{{5-(4-叔丁基苯基)-[1,3,4]-噁二唑}-2-苯基}-乙烯基-1,8-萘酰亚胺}-乙氨基羰乙基}乙氨基-1,8-萘酰亚胺(DOPN).并通过核磁氢谱、核磁碳谱及高分辨质谱结构表征.测定了DON及DOPN的固体、纯THF及水溶液中的荧光光谱,实验发现暗室中紫外灯下固体DON和DOPN发出橘黄色荧光,最大发射波长分别为566和561nm.在四氢呋喃(THF)溶液中发出蓝绿色荧光,最大吸收波长为360和395nm,最大发射波长为489和492nm,荧光量子产率为28.2%和20.4%.水溶液中最大吸收波长为367和408nm,最大发射波长为563和552nm.测定了DON和DOPN与Hela细胞共同孵化后在共聚焦荧光显微镜下的细胞成像.研究了DON对Sn2+的选择性识别实验,研究发现,Sn2+对DON有选择性荧光增强,Sn2+与DON配位数为2.萘酰亚胺树形分子DON和DOPN可溶于水,具有聚集诱导发光(AIE)性质,是一种优良的Sn2+荧光探针,可广泛应用于肿瘤定位、药学研究、荧光显微技术及纳米材料研究的应用等重要领域.
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