OALib Journal期刊
应答流感病毒感染的宿主信号途径研究进展
, PP. 993-1001
Keywords: 流感病毒 ,病毒与宿主相互作用 ,信号转导 ,宿主模式识别受体 ,病毒增殖 ,翻译控制 ,细胞凋亡 ,磷脂酰肌醇-3-激酶信号通路
Abstract:
一系列广泛的宿主细胞信号转导通路可以被流感病毒感染激活.一些信号转导通路引起宿主细胞的先天免疫应答来抵抗流感病毒,而一些其他的信号转导通路却是流感病毒实现高效复制所必需的.本文综述了宿主细胞中由流感病毒感染引起的胞内信号转导,包括宿主模式识别受体(PRRs)相关信号,PKC,Raf/MEK/ERK和PI3K/Akt信号,同时对上述信号通路的下游具体效应进行了总结.这些效应包括宿主细胞对流感病毒的识别,流感病毒的吸附及入侵,流感病毒核蛋白的输出,病毒蛋白的翻译控制,流感病毒引起的宿主细胞凋亡.对流感病毒引起的细胞信号转导的研究有助于更加清晰地认识病毒与宿主的相互作用,也是寻找新的抗病毒靶点和新的抗病毒策略的基础.
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