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OALib Journal期刊
ISSN: 2333-9721
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免疫抑制沙鼠源肺孢子菌的分类地位
, PP. 1055-1062
Keywords: 肺孢子菌,长爪沙鼠,5.8S核糖体RNA基因,rRNA基因内转录间隔区,线粒体核糖体大亚基,18S核糖体RNA基因
Abstract:
肺孢子菌能够感染多种哺乳动物的肺脏,并在免疫受抑制的个体引起肺孢子菌肺炎.研究表明,肺孢子菌分离株在系统进化树上分为两大枝,二者所含菌株分别来源于灵长类和啮齿类.基于宿主特异性以及DNA序列和形态学差异,每一分枝内的菌株又可分为不同的种.本研究采用地塞米松免疫抑制法,导致沙鼠(28/35)肺组织感染.对18S,5.8SrRNA和rRNA内转录间隔区基因序列,以及线粒体核糖体大亚基基因的部分序列分析表明,本实验沙鼠源肺孢子菌与啮齿类动物来源的同属一枝,但明显区别于其他啮齿类动物来源的菌株,应考虑是一个独立的菌种.
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