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OALib Journal期刊
ISSN: 2333-9721
费用：99美元
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肿瘤:一种蛋白质组病
, PP. 788-794
Keywords: 肿瘤,蛋白质组病,蛋白质表达谱,翻译后修饰蛋白质组,蛋白质相互作用
Abstract:
恶性肿瘤的发生是一个涉及多因素、多基因的多阶段病理过程.以往的研究主要集中在基因组和转录组分析.随着人类基因组计划的完成,肿瘤研究开始进入“后基因组时代”,肿瘤蛋白质组学应运而生.蛋白质作为基因功能的主要执行者,一方面在肿瘤发生发展过程中扮演重要角色,另一方面在很大程度上决定正常细胞和肿瘤细胞之间的差异(如异型性、恶性特征等).本文提出,肿瘤是一种蛋白质组病,并根据肿瘤比较蛋白质组、表达蛋白质组、功能蛋白质组和结构蛋白质组研究进展,从肿瘤发生发展过程中蛋白质(组)表达水平及状态、蛋白质翻译后修饰、蛋白质相互作用及网络调控等三个方面进行阐述.该观点的提出,将为肿瘤发病机制的研究开辟新的领域,为肿瘤的诊断(如生物标志物筛选)和筛选(如药物新靶标)提供新的思路,具有重要的科学意义和临床应用价值.
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