1 Bothwell T H. Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr, 2000, 72: S257-S264
[2]
2 Danzeisen R, Fosset C, Chariana Z, et al. Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in ironmetabolism. Am J Physiol Cell Physiol, 2002, 282: C472-C478
[3]
3 Andersen H S, Gambling L, Holtrop G, et al. Effect of dietary copper deficiency on iron metabolism in the pregnant rat. Br J Nutr, 2007, 97:239-246？？
[4]
4 Danzeisen R, Ponnambalam S, Lea R G, et al. The effect of ceruloplasmin on iron release from placental (BeWo) cells, evidence for anendogenous Cu oxidase. Placenta, 2000, 21: 805-812？？
[5]
5 Chen H, Attieh Z K, Syed B A, et al. Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, andcharacterization in rodents and human cells. J Nutr, 2010, 140: 1728-1735？？
[6]
18 Gruper Y, Bar J, Bacharach E, et al. Transferrin receptor co-localizes and interacts with the hemochromatosis factor(HFE) and the divalentmetal transporter-1(DMT1) in trophoblast cells. J Cell Physiol, 2005, 204: 901-912？？
[7]
19 Parkkila S, Waheed A, Britton R S, et al. Association of the transferrin receptor in human placenta with HFE, the protein defective inhereditary hemochromatosis. Proc Natl Acad Sci USA, 1997, 94: 13198-13202？？
[8]
20 Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature,2000, 403: 776-781？？
[9]
21 Bastin J, Drakesmith H, Rees M, et al. Localisation of proteins of iron metabolism in the human placenta and liver. Br J Haematol, 2006,134: 532-543？？
[10]
22 McArdle H J, Andersen H S, Jones H, et al. Copper and iron transport across the placenta: regulation and interactions. J Neuroendocrinol,2008, 20: 427-431？？
[11]
16 Dumartin B, Canivenc R. Placental iron transfer regulation in the haemophagous region of the badger placenta: ultrastructural localizationof ferritin in trophoblast and endothelial cells. Anat Embryol(Berl), 1992, 185: 175-179
[12]
17 Takami M, Mizumoto K, Kasuya I, et al. Human placental ferritin receptor. Biochim Biophys Acta, 1986, 884: 31-38？？
[13]
6 Prohaska J R. Impact of copper limitation on expression and function of multicopper oxidases(Ferroxidases). Adv Nutr, 2011, 2: 89-95
[14]
7 常彦忠, 钱忠明. 铜蓝蛋白与脑铁代谢. 生理科学进展, 2002, 32: 101-105
[15]
8 Hahn P, Qian Y, Dentchev T, et al. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degenerationwith features of age-related macular degeneration. Proc Natl Acad Sci USA, 2004, 101: 13850-13855？？
[16]
9 Cui R, Duan X L, Anderson G J, et al. Age-dependent expression of hephaestin in the brain of ceruloplasmin-deficient mice. J Trace ElemMed Biol, 2009, 23: 290-299？？
[17]
10 Petrak J, Vyoral D. Hephaestin-a ferroxidase of cellular iron export. Int J Biochem Cell Biol, 2005, 37: 1173-1178？？
[18]
11 Evans J L, Abraham P A. Anemia, iron storage and ceruloplasmin in copper nutrition in the growing rat. J Nutr, 1973, 103: 196-201
[19]
12 Andersen H S, Gambling L, Holtrop G, et al. Effect of dietary copper deficiency on iron metabolism in the pregnant rat. Br J Nutr, 2007, 97:239-246？？
[20]
13 Gambling L, Charania Z, Hannah L, et al. Effect of iron deficiency on placental cytokine expression and fetal growth in the pregnant rat.Biol Reprod, 2002, 66: 516-523？？
[21]
14 Heaton S J, Eady J J, Parker M L, et al. The use of BeWo cells as an in vitro model for placental iron transport. Am J Physiol Cell Physiol,2008, 295: C1445-C1453？？
[22]
15 Okuyama T, Tawada T, Furuya H, et al. The role of transferrin and ferritin in the fetal-maternal-placental unit. Am J Obstet Gynecol, 1985,152: 344-350
