1 Semenza G L. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol, 2001, 13: 167-171？？
[2]
2 Semenza G L. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev, 2010, 20: 51-56？？
[3]
3 Horowitz M. Genomics and proteomics of heat acclimation. Front Biosci (Schol Ed), 2010, 2: 1068-1080
[4]
4 Sun F Y, Guo X. Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor. J Neurosci Res, 2005, 79:180-184？？
[5]
5 Chen W Y, Chang M S. IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. J Immunol,2009, 182: 5003-5012？？
[6]
6 Choi Y K, Kim C K, Lee H, et al. Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinctmechanisms, translational activation and stabilization of HIF-1alpha protein. J Biol Chem, 2010, 285: 32116-32125
8 Solaini G, Baracca A, Lenaz G, et al. Hypoxia and mitochondrial oxidative metabolism. Biochim Biophys Acta, 2010, 1797: 1171-1177？？
[9]
9 Moeller B J, Cao Y, Li C Y, et al. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, freeradical, and stress granules. Cancer Cell, 2004, 5: 429-441？？
[10]
10 Gorski D H, Beckett M A, Jaskowiak N T, et al. Blockage of the vascular endothelial growth factor stress response increases the antitumoreffects of ionizing radiation. Cancer Res, 1999, 59: 3374-3378
12 Fan X, Heijnen C J, van der Kooij M A, et al. The role and regulation of hypoxia-inducible factor-1alpha expression in brain developmentand neonatal hypoxic-ischemic brain injury. Brain Res Rev, 2009, 62: 99-108？？
[13]
13 Moon E J, Sonveaux P, Porporato P E, et al. NADPH oxidase-mediated reactive oxygen species production activates hypoxia-induciblefactor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. Proc Natl Acad Sci USA, 2010, 107: 20477-20482？？
[14]
14 Pages G, Milanini J, Richard D E, et al. Signaling angiogenesis via p42/p44 MAP kinase cascade. Ann N Y Acad Sci, 2000, 902: 187-200
[15]
15 Narasimhan P, Liu J, Song Y S, et al. VEGF Stimulates the ERK 1/2 signaling pathway and apoptosis in cerebral endothelial cells afterischemic conditions. Stroke, 2009, 40: 1467-1473？？
[16]
16 Minet E, Michel G, Mottet D, et al. Transduction pathways involved in hypoxia-inducible factor-1 phosphorylation and activation. FreeRadic Biol Med, 2001, 31: 847-855？？
[17]
17 Hur E, Chang K Y, Lee E, et al. Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the transactivation but not thestabilization or DNA binding ability of hypoxia-inducible factor-1 alpha. Mol Pharmacol, 2001, 59: 1216-1224
